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International Urology and Nephrology

, Volume 50, Issue 11, pp 1939–1948 | Cite as

Pharmacotherapy of premature ejaculation: a systematic review and network meta-analysis

  • Zhongyu Jian
  • Xin Wei
  • Donghui Ye
  • Hong Li
  • Kunjie WangEmail author
Urology - Review
  • 382 Downloads

Abstract

Purpose

The purpose of the study was to conduct a systematic evaluation of the different general prescribed drugs for premature ejaculation (PE).

Methods

A systematic literature search of MEDLINE, Cochrane Central Register of Controlled Trials, and Web of Science for Systematic Reviews was performed on 1 March 2018. Intravaginal ejaculation latency time (IELT) was the main outcome. Analysis was performed under multivariate random-effects network model and efficacies of drugs were ranked with surface under the cumulative ranking (SUCRA) probabilities.

Results

A total of 48 studies were reviewed and 40 of them were further enrolled into network meta-analysis. The majority of RCTs were of unclear methodological quality. Pooled evidence suggested that topical anaesthetic creams (TAs), tramadol, selective serotonin reuptake inhibitors (SSRIs), and phosphodiesterase type 5 inhibitors (PDE5is) are more effective at prolonging IELT comparing with placebo. TAs (90%) on demand (OD) and PDE5is plus SSRI (89.8%) had the highest SUCRA, which meant the most probable to be the most effective intervention.

Conclusions

We recommend the initial use of dapoxetine 30 mg OD for PE because it has been tested in largest and better designed clinical trials rather than it is more effective than the other drugs studied. TAs and tramadol 50 mg OD can be used as a viable alternative to oral treatment with SSRIs. PDE5is combined with SSRIs are more effective than SSRIs monotherapy but are also associated with more side effects. PDE5is OD can be recommended to PE patients with ED.

Keywords

Sexual health Premature ejaculation Medical treatment Pharmacology of ejaculation 

Notes

Author contributions

ZJ and XW: project development, data collection and management, manuscript writing and revising, data analysis; DY: data collection, data analysis and revising; HL: data collection, data analysis; KW: project design and development, data interpretation, manuscript editing and revising. All authors read and approved the final manuscript.

Funding

This article is supported by grants from 1.3.5 project for disciplines of excellence, West China Hospital, Sichuan University (ZY2016104), Project of the Health and Family Planning Committee of Sichuan Province and The popularization and promotion of ureteroscopic technique in the treatment of upper urinary tract stones in primary hospitals (16PI294).

Compliance with ethical standards

Conflict of interest

The authors of this article as well as all the included studies declare that they have no conflict of interest.

Ethical approval

This article does not contain any studies with human participants or animals performed by any of the authors.

Informed consent

Informed consent was obtained from all individual participants included in the study.

Supplementary material

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References

  1. 1.
    Porst H, Montorsi F, Rosen RC, Gaynor L, Grupe S, Alexander J (2007) The Premature Ejaculation Prevalence and Attitudes (PEPA) survey: prevalence, comorbidities, and professional help-seeking. Eur Urol 51(3):816–823.  https://doi.org/10.1016/j.eururo.2006.07.004 (discussion 824)CrossRefPubMedGoogle Scholar
  2. 2.
    Serefoglu EC, McMahon CG, Waldinger MD, Althof SE, Shindel A, Adaikan G, Becher EF, Dean J, Giuliano F, Hellstrom WJ, Giraldi A, Glina S, Incrocci L, Jannini E, McCabe M, Parish S, Rowland D, Segraves RT, Sharlip I, Torres LO (2014) An evidence-based unified definition of lifelong and acquired premature ejaculation: report of the second international society for sexual medicine ad hoc committee for the definition of premature ejaculation. J Sex Med 2(2):41–59.  https://doi.org/10.1002/sm2.27 CrossRefGoogle Scholar
  3. 3.
    Waldinger MD, Schweitzer DH (2006) Changing paradigms from a historical DSM-III and DSM-IV view toward an evidence-based definition of premature ejaculation. Part II–proposals for DSM-V and ICD-11. J Sex Med 3(4):693–705.  https://doi.org/10.1111/j.1743-6109.2006.00276.x CrossRefPubMedGoogle Scholar
  4. 4.
    Rowland D, Perelman M, Althof S, Barada J, McCullough A, Bull S, Jamieson C, Ho KF (2004) Self-reported premature ejaculation and aspects of sexual functioning and satisfaction. J Sex Med 1(2):225–232CrossRefGoogle Scholar
  5. 5.
    Rowland DL, Patrick DL, Rothman M, Gagnon DD (2007) The psychological burden of premature ejaculation. J Urol 177(3):1065–1070.  https://doi.org/10.1016/j.juro.2006.10.025 CrossRefPubMedGoogle Scholar
  6. 6.
    Symonds T, Roblin D, Hart K, Althof S (2003) How does premature ejaculation impact a man s life? J Sex Marital Ther 29(5):361–370.  https://doi.org/10.1080/00926230390224738 CrossRefPubMedGoogle Scholar
  7. 7.
    Richardson D, Goldmeier D, Green J, Lamba H, Harris JR (2006) Recommendations for the management of premature ejaculation: BASHH Special Interest Group for Sexual Dysfunction. Int J STD AIDS 17(1):1–6.  https://doi.org/10.1258/095646206775220540 CrossRefPubMedGoogle Scholar
  8. 8.
    Martyn-St James M, Cooper K, Ren S, Kaltenthaler E, Dickinson K, Cantrell A, Wylie K, Frodsham L, Hood C (2017) Phosphodiesterase-5 inhibitors for premature ejaculation: a systematic review and meta-analysis. Eur Urol Focus 3(1):119–129.  https://doi.org/10.1016/j.euf.2016.02.001 CrossRefPubMedPubMedCentralGoogle Scholar
  9. 9.
    Sun Y, Yang L, Bao Y, Liu Z, Liu L, Wei Q (2017) Efficacy of PDE5Is and SSRIs in men with premature ejaculation: a new systematic review and five meta-analyses. World J Urol 35(12):1817–1831.  https://doi.org/10.1007/s00345-017-2086-5 CrossRefPubMedGoogle Scholar
  10. 10.
    Castiglione F, Albersen M, Hedlund P, Gratzke C, Salonia A, Giuliano F (2016) Current pharmacological management of premature ejaculation: a systematic review and meta-analysis. Eur Urol 69(5):904–916.  https://doi.org/10.1016/j.eururo.2015.12.028 CrossRefPubMedGoogle Scholar
  11. 11.
    Mills EJ, Thorlund K, Ioannidis JP (2013) Demystifying trial networks and network meta-analysis. BMJ 346:f2914.  https://doi.org/10.1136/bmj.f2914 CrossRefPubMedGoogle Scholar
  12. 12.
    Moher D, Liberati A, Tetzlaff J, Altman DG (2009) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med 6(7):e1000097.  https://doi.org/10.1371/journal.pmed.1000097 CrossRefPubMedPubMedCentralGoogle Scholar
  13. 13.
    Salanti G, Ades AE, Ioannidis JP (2011) Graphical methods and numerical summaries for presenting results from multiple-treatment meta-analysis: an overview and tutorial. J Clin Epidemiol 64(2):163–171.  https://doi.org/10.1016/j.jclinepi.2010.03.016 CrossRefPubMedGoogle Scholar
  14. 14.
    White IR (2009) Multivariate random-effects meta-analysis. Stata J 9(1):40–56Google Scholar
  15. 15.
    Waldinger MD, Hengeveld MW, Zwinderman AH (1994) Paroxetine treatment of premature ejaculation: a double-blind, randomized, placebo-controlled study. Am J Psychiatry 151(9):1377–1379.  https://doi.org/10.1176/ajp.151.9.1377 CrossRefPubMedGoogle Scholar
  16. 16.
    Kara H, Aydin S, Yucel M, Agargun MY, Odabas O, Yilmaz Y (1996) The efficacy of fluoxetine in the treatment of premature ejaculation: a double-blind placebo controlled study. J Urol 156(5):1631–1632CrossRefGoogle Scholar
  17. 17.
    Kim SC, Seo KK (1998) Efficacy and safety of fluoxetine, sertraline and clomipramine in patients with premature ejaculation: a double-blind, placebo controlled study. J Urol 159(2):425–427CrossRefGoogle Scholar
  18. 18.
    Waldinger MD, Hengeveld MW, Zwinderman AH, Olivier B (1998) Effect of SSRI antidepressants on ejaculation: a double-blind, randomized, placebo-controlled study with fluoxetine, fluvoxamine, paroxetine, and sertraline. J Clin Psychopharmacol 18(4):274–281CrossRefGoogle Scholar
  19. 19.
    Biri H, Isen K, Sinik Z, Onaran M, Kupeli B, Bozkirli I (1998) Sertraline in the treatment of premature ejaculation: a double-blind placebo controlled study. Int Urol Nephrol 30(5):611–615CrossRefGoogle Scholar
  20. 20.
    McMahon CG (1998) Treatment of premature ejaculation with sertraline hydrochloride: a single-blind placebo controlled crossover study. J Urol 159(6):1935–1938CrossRefGoogle Scholar
  21. 21.
    Yilmaz U, Tatlisen A, Turan H, Arman F, Ekmekcioglu O (1999) The effects of fluoxetine on several neurophysiological variables in patients with premature ejaculation. J Urol 161(1):107–111CrossRefGoogle Scholar
  22. 22.
    McMahon CG, Touma K (1999) Treatment of premature ejaculation with paroxetine hydrochloride as needed: 2 single-blind placebo controlled crossover studies. J Urol 161(6):1826–1830CrossRefGoogle Scholar
  23. 23.
    Waldinger MD, Zwinderman AH, Olivier B (2001) Antidepressants and ejaculation: a double-blind, randomized, placebo-controlled, fixed-dose study with paroxetine, sertraline, and nefazodone. J Clin Psychopharmacol 21(3):293–297CrossRefGoogle Scholar
  24. 24.
    Atmaca M, Kuloglu M, Tezcan E, Semercioz A (2002) The efficacy of citalopram in the treatment of premature ejaculation: a placebo-controlled study. Int J Impot Res 14(6):502–505.  https://doi.org/10.1038/sj.ijir.3900918 CrossRefPubMedGoogle Scholar
  25. 25.
    Novaretti JP, Pompeo AC, Arap S (2002) Selective serotonin re-uptake inhibitor in the treatment of premature ejaculation. Braz J Urol 28(2):116–122Google Scholar
  26. 26.
    Atikeler MK, Gecit I, Senol FA (2002) Optimum usage of prilocaine-lidocaine cream in premature ejaculation. Andrologia 34(6):356–359CrossRefGoogle Scholar
  27. 27.
    Busato W, Galindo CC (2004) Topical anaesthetic use for treating premature ejaculation: a double-blind, randomized, placebo-controlled study. BJU Int 93(7):1018–1021.  https://doi.org/10.1111/j.1464-410X.2003.04773.x CrossRefPubMedGoogle Scholar
  28. 28.
    McMahon CG, Stuckey BG, Andersen M, Purvis K, Koppiker N, Haughie S, Boolell M (2005) Efficacy of sildenafil citrate (Viagra) in men with premature ejaculation. J Sex Med 2(3):368–375.  https://doi.org/10.1111/j.1743-6109.2005.20351.x CrossRefPubMedGoogle Scholar
  29. 29.
    Pryor JL, Althof SE, Steidle C, Rosen RC, Hellstrom WJ, Shabsigh R, Miloslavsky M, Kell S (2006) Efficacy and tolerability of dapoxetine in treatment of premature ejaculation: an integrated analysis of two double-blind, randomised controlled trials. Lancet 368(9539):929–937.  https://doi.org/10.1016/s0140-6736(06)69373-2 CrossRefPubMedGoogle Scholar
  30. 30.
    Arafa M, Shamloul R (2006) Efficacy of sertraline hydrochloride in treatment of premature ejaculation: a placebo-controlled study using a validated questionnaire. Int J Impot Res 18(6):534–538.  https://doi.org/10.1038/sj.ijir.3901469 CrossRefPubMedGoogle Scholar
  31. 31.
    Safarinejad MR, Hosseini SY (2006) Safety and efficacy of tramadol in the treatment of premature ejaculation: a double-blind, placebo-controlled, fixed-dose, randomized study. J Clin Psychopharmacol 26(1):27–31CrossRefGoogle Scholar
  32. 32.
    Hosseini MM, Yarmohammadi H (2007) Effect of fluoxetine alone and in combination with sildenafil in patients with premature ejaculation. Urol Int 79(1):28–32.  https://doi.org/10.1159/000102909 CrossRefPubMedGoogle Scholar
  33. 33.
    Wang WF, Wang Y, Minhas S, Ralph DJ (2007) Can sildenafil treat primary premature ejaculation? A prospective clinical study. Int J Urol 14(4):331–335.  https://doi.org/10.1111/j.1442-2042.2007.01606.x CrossRefPubMedGoogle Scholar
  34. 34.
    Dinsmore WW, Hackett G, Goldmeier D, Waldinger M, Dean J, Wright P, Callander M, Wylie K, Novak C, Keywood C, Heath P, Wyllie M (2007) Topical eutectic mixture for premature ejaculation (TEMPE): a novel aerosol-delivery form of lidocaine-prilocaine for treating premature ejaculation. BJU Int 99(2):369–375.  https://doi.org/10.1111/j.1464-410X.2006.06583.x CrossRefPubMedGoogle Scholar
  35. 35.
    Mattos RM, Marmo Lucon A, Srougi M (2008) Tadalafil and fluoxetine in premature ejaculation: prospective, randomized, double-blind, placebo-controlled study. Urol Int 80(2):162–165.  https://doi.org/10.1159/000112607 CrossRefPubMedGoogle Scholar
  36. 36.
    Salem EA, Wilson SK, Bissada NK, Delk JR, Hellstrom WJ, Cleves MA (2008) Tramadol HCL has promise in on-demand use to treat premature ejaculation. J Sex Med 5(1):188–193.  https://doi.org/10.1111/j.1743-6109.2006.00424.x CrossRefPubMedGoogle Scholar
  37. 37.
    Steggall MJ, Fowler CG, Pryce A (2008) Combination therapy for premature ejaculation: results of a small-scale study. Sex Relationsh Ther 23(4):365–376CrossRefGoogle Scholar
  38. 38.
    Aversa A, Pili M, Francomano D, Bruzziches R, Spera E, La Pera G, Spera G (2009) Effects of vardenafil administration on intravaginal ejaculatory latency time in men with lifelong premature ejaculation. Int J Impot Res 21(4):221–227.  https://doi.org/10.1038/ijir.2009.21 CrossRefPubMedGoogle Scholar
  39. 39.
    Farnia V, Raisi F, Mohseni MG, Atharikia D, Ghafuri Z (2009) On-demand treatment of premature ejaculation with citalopram: a randomized double-blind study. Acta Med Iran 47(5):353–357Google Scholar
  40. 40.
    Buvat J, Tesfaye F, Rothman M, Rivas DA, Giuliano F (2009) Dapoxetine for the treatment of premature ejaculation: results from a randomized, double-blind, placebo-controlled phase 3 trial in 22 countries. Eur Urol 55(4):957–967.  https://doi.org/10.1016/j.eururo.2009.01.025 CrossRefPubMedGoogle Scholar
  41. 41.
    Mathers MJ, Klotz T, Roth S, Lummen G, Sommer F (2009) Safety and efficacy of vardenafil versus sertraline in the treatment of premature ejaculation: a randomised, prospective and crossover study. Andrologia 41(3):169–175.  https://doi.org/10.1111/j.1439-0272.2008.00910.x CrossRefPubMedGoogle Scholar
  42. 42.
    Dinsmore WW, Wyllie MG (2009) PSD502 improves ejaculatory latency, control and sexual satisfaction when applied topically 5 min before intercourse in men with premature ejaculation: results of a phase III, multicentre, double-blind, placebo-controlled study. BJU Int 103(7):940–949.  https://doi.org/10.1111/j.1464-410X.2009.08456.x CrossRefPubMedGoogle Scholar
  43. 43.
    McMahon C, Kim SW, Park NC, Chang CP, Rivas D, Tesfaye F, Rothman M, Aquilina J (2010) Treatment of premature ejaculation in the Asia-Pacific region: results from a phase III double-blind, parallel-group study of dapoxetine. J Sex Med 7(1 Pt 1):256–268.  https://doi.org/10.1111/j.1743-6109.2009.01560.x CrossRefPubMedGoogle Scholar
  44. 44.
    Carson C, Wyllie M (2010) Improved ejaculatory latency, control and sexual satisfaction when PSD502 is applied topically in men with premature ejaculation: results of a phase III, double-blind, placebo-controlled study. J Sex Med 7(9):3179–3189.  https://doi.org/10.1111/j.1743-6109.2010.01913.x CrossRefPubMedGoogle Scholar
  45. 45.
    Alghobary M, El-Bayoumy Y, Mostafa Y, Mahmoud el HM, Amr M (2010) Evaluation of tramadol on demand vs. daily paroxetine as a long-term treatment of lifelong premature ejaculation. J Sex Med 7(8):2860–2867.  https://doi.org/10.1111/j.1743-6109.2010.01789.x CrossRefPubMedGoogle Scholar
  46. 46.
    Gokce A, Demirtas A, Halis F, Ekmekcioglu O (2010) In vitro measurement of ejaculation latency time (ELT) and the effects of vardenafil on ELT on lifelong premature ejaculators: placebo-controlled, double-blind, cross-over laboratory setting. Int Urol Nephrol 42(4):881–887.  https://doi.org/10.1007/s11255-010-9710-2 CrossRefPubMedGoogle Scholar
  47. 47.
    Gokce A, Halis F, Demirtas A, Ekmekcioglu O (2011) The effects of three phosphodiesterase type 5 inhibitors on ejaculation latency time in lifelong premature ejaculators: a double-blind laboratory setting study. BJU Int 107(8):1274–1277.  https://doi.org/10.1111/j.1464-410X.2010.09646.x CrossRefPubMedGoogle Scholar
  48. 48.
    Bar-Or D, Salottolo KM, Orlando A, Winkler JV, Tramadol ODT Study Group (2012) A randomized double-blind, placebo-controlled multicenter study to evaluate the efficacy and safety of two doses of the tramadol orally disintegrating tablet for the treatment of premature ejaculation within less than 2 minutes. Eur Urol 61(4):736–743CrossRefGoogle Scholar
  49. 49.
    Kaynar M, Kilic O, Yurdakul T (2012) On-demand tramadol hydrochloride use in premature ejaculation treatment. Urology 79(1):145–149.  https://doi.org/10.1016/j.urology.2011.09.031 CrossRefPubMedGoogle Scholar
  50. 50.
    McMahon CG, Giuliano F, Dean J, Hellstrom WJ, Bull S, Tesfaye F, Sharma O, Rivas DA, Aquilina JW (2013) Efficacy and safety of dapoxetine in men with premature ejaculation and concomitant erectile dysfunction treated with a phosphodiesterase type 5 inhibitor: randomized, placebo-controlled, phase III study. J Sex Med 10(9):2312–2325.  https://doi.org/10.1111/jsm.12236 CrossRefPubMedGoogle Scholar
  51. 51.
    Eassa BI, El-Shazly MA (2013) Safety and efficacy of tramadol hydrochloride on treatment of premature ejaculation. Asian J Androl 15(1):138–142.  https://doi.org/10.1038/aja.2012.96 CrossRefPubMedGoogle Scholar
  52. 52.
    Lee WK, Lee SH, Cho ST, Lee YS, Oh CY, Yoo C, Cho JS, Lee SK, Yang DY (2013) Comparison between on-demand dosing of dapoxetine alone and dapoxetine plus mirodenafil in patients with lifelong premature ejaculation: prospective, randomized, double-blind, placebo-controlled, multicenter study. J Sex Med 10(11):2832–2841.  https://doi.org/10.1111/jsm.12287 CrossRefPubMedGoogle Scholar
  53. 53.
    Gameel TA, Tawfik AM, Abou-Farha MO, Bastawisy MG, El-Bendary MA, El-Gamasy Ael N (2013) On-demand use of tramadol, sildenafil, paroxetine and local anaesthetics for the management of premature ejaculation: a randomised placebo-controlled clinical trial. Arab J Urol 11(4):392–397.  https://doi.org/10.1016/j.aju.2013.05.003 CrossRefPubMedPubMedCentralGoogle Scholar
  54. 54.
    Khan AH, Rasaily D (2013) Tramadol use in premature ejaculation: daily versus sporadic treatment. Indian J Psychol Med 35(3):256–259.  https://doi.org/10.4103/0253-7176.119477 CrossRefPubMedPubMedCentralGoogle Scholar
  55. 55.
    Zhang X (2014) Combination of sertraline and sildenafil versus sertraline monotherapy in the treatment of acquired premature ejaculation without concomitant diseases. Androl-Open Access 03(1)Google Scholar
  56. 56.
    Polat EC, Ozbek E, Otunctemur A, Ozcan L, Simsek A (2015) Combination therapy with selective serotonin reuptake inhibitors and phosphodiesterase-5 inhibitors in the treatment of premature ejaculation. Andrologia 47(5):487–492.  https://doi.org/10.1111/and.12289 CrossRefPubMedGoogle Scholar
  57. 57.
    Kurkar A, Elderwy AA, Abulsorour S, Awad SM, Safwat AS, Altaher A (2015) A randomized, double-blind, placebo-controlled, crossover trial of “on-demand” tramadol for treatment of premature ejaculation. Urol Ann 7(2):205–210.  https://doi.org/10.4103/0974-7796.150481 CrossRefPubMedPubMedCentralGoogle Scholar
  58. 58.
    Moudi E, Kasaeeyan AA (2016) Comparison between tadalafil plus paroxetine and paroxetine alone in the treatment of premature ejaculation. Nephro-urol Mon 8(1):e32286.  https://doi.org/10.5812/numonthly.32286 CrossRefGoogle Scholar
  59. 59.
    Dell’Atti L, Galosi AB, Ippolito C (2017) A randomized single-center study to compare the efficacy and tolerability of tadalafil once daily plus lidocaine anesthetic spray on premature ejaculation. Eur Rev Med Pharmacol Sci 21(5):1036–1040PubMedGoogle Scholar
  60. 60.
    Homayuonfar A, Aminsharifi A, Salehi A, Sahraian A, Dehshari S, Bahrami M (2018) A randomized double-blind placebo-controlled trial to assess the effect of tamarind seed in premature ejaculation. Adv Biomed Res 7:59.  https://doi.org/10.4103/abr.abr_16_17 CrossRefPubMedPubMedCentralGoogle Scholar
  61. 61.
    Abu El-Hamd M, Abdelhamed A (2018) Comparison of the clinical efficacy and safety of the on-demand use of paroxetine, dapoxetine, sildenafil and combined dapoxetine with sildenafil in treatment of patients with premature ejaculation: a randomised placebo-controlled clinical trial. Andrologia.  https://doi.org/10.1111/and.12829 CrossRefPubMedGoogle Scholar
  62. 62.
    Hamidi-Madani A, Motiee R, Mokhtari G, Nasseh H, Esmaeili S, Kazemnezhad E (2018) The efficacy and safety of on-demand tramadol and paroxetine use in treatment of life long premature ejaculation: a randomized double-blind placebo-controlled clinical trial. J Reprod Infertil 19(1):10–15PubMedPubMedCentralGoogle Scholar
  63. 63.
    Epstein DH, Preston KL, Jasinski DR (2006) Abuse liability, behavioral pharmacology, and physical-dependence potential of opioids in humans and laboratory animals: lessons from tramadol. Biol Psychol 73(1):90–99.  https://doi.org/10.1016/j.biopsycho.2006.01.010 CrossRefPubMedPubMedCentralGoogle Scholar
  64. 64.
    Dechartres A, Boutron I, Trinquart L, Charles P, Ravaud P (2011) Single-center trials show larger treatment effects than multicenter trials: evidence from a meta-epidemiologic study. Ann Intern Med 155(1):39–51.  https://doi.org/10.7326/0003-4819-155-1-201107050-00006 CrossRefPubMedGoogle Scholar

Copyright information

© Springer Nature B.V. 2018

Authors and Affiliations

  1. 1.Department of Urology, Institute of Urology (Laboratory of Reconstructive Urology), West China HospitalSichuan UniversityChengduPeople’s Republic of China

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