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International Urology and Nephrology

, Volume 50, Issue 11, pp 1975–1980 | Cite as

Serum vitamin D level may be a novel potential risk factor for premature ejaculation: a comparative study

  • Alaa Mohamed Abd El aal
  • Sameh Fayek GamalEl Din
  • Laila Ahmed Rashed
  • Abd El Rahman Bakry Tawfik
  • Mohammed Said ElSheemyEmail author
Urology - Original Paper

Abstract

Purpose

To compare serum level of vitamin D [25(OH)D] in patients with life-long premature ejaculation (LPE) versus healthy controls.

Methods

Healthy married potent males were recruited from February 2017 to January 2018. Group A included 40 patients suffering from LPE who were compared versus 40 healthy controls (Group B). Participants suffering from hormonal disorders, obesity, neurological, psychological, or chronic diseases or taking medications that may affect ejaculatory function, serum level of vitamin D, or the accuracy of intra-vaginal ejaculation latency time (IELT) were excluded. LPE was self-reported by the patients with subsequent feelings of frustration and measured by premature ejaculation diagnostic tool (PEDT) and IELT using stopwatch handled by their partners. 25(OH)D was measured by obtaining 2 ml of venous blood. Statistical analysis was performed using Student t, Mann–Whitney, Chi square tests, logistic regression analysis, and Spearman correlation.

Results

Sixteen (20%) participants had vitamin D insufficiency/deficiency. All of them were in PE group. 25(OH)D correlated significantly with IELT (r2 = 0.349; p < 0.001) and PEDT (r2 = 0.425; p < 0.001). There was no statistically significant difference in age (p = 0.341), BMI (p = 1) or IIEF-5 (p = 0.408) in both groups. 25(OH)D was significantly lower in patients than controls (35.75 vs. 58.92 ng/ml, p < 0.001). ROC analysis revealed that the best cut-off value of 25(OH)D to detect patients suffering from LPE was 50.65 ng/ml with a sensitivity and specificity of 85% for both. 25(OH)D remained a significant risk factor for LPE in the logistic regression analysis (p < 0.001).

Conclusions

The current study showed that vitamin D has significant association with LPE and correlates significantly with IELT and PEDT.

Keywords

Lifelong premature ejaculation Serotonin Serum vitamin D Tryptophan hydroxylase Vitamin D deficiency 

Notes

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest. No Funding Source or industrial links and affiliations.

Ethical approval

All procedures performed were in accordance with the ethical standards of the institutional and national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. The study was approved by the local ethical committee.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Copyright information

© Springer Nature B.V. 2018

Authors and Affiliations

  • Alaa Mohamed Abd El aal
    • 1
  • Sameh Fayek GamalEl Din
    • 1
  • Laila Ahmed Rashed
    • 2
  • Abd El Rahman Bakry Tawfik
    • 3
  • Mohammed Said ElSheemy
    • 4
    Email author
  1. 1.Andrology & STDs Department, Kasr Alainy Faculty of MedicineCairo UniversityCairoEgypt
  2. 2.Biochemistry Department, Kasr Alainy Faculty of MedicineCairo UniversityCairoEgypt
  3. 3.Ministry of HealthCairoEgypt
  4. 4.Urology Department, Kasr Alainy Faculty of Medicine, Kasr Al-Ainy HospitalsCairo UniversityCairoEgypt

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