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The association between high-density lipoproteins and estimated glomerular filtration rate in patients without severe kidney disease

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Several studies investigated the association between the estimated glomerular filtration rate (eGFR) and the concentration of high-density lipoproteins (HDL) in patients without severely damaged kidney function. As results of those studies were inconclusive and contradictory, we wanted to investigate this association in multiple cardiovascular disease (CVD) risk patients without severe kidney disease or renal failure.


We enrolled a cohort of 187 patients with intermediate and high CVD risk without severe renal disease. We grouped them based on their eGFR into: group 1 (≥ 30 < 60 ml/min/1.73 m2), group 2 (≥ 60 < 90 ml/min/1.73 m2) and group 3 (≥ 90 ml/min/1.73 m2). We analyzed the difference between their HDL levels and assessed the association of HDL and eGFR in three regression models with the following predictors: model 1 (age and gender), model 2 (model 1 plus smoking status, hs-CRP and diabetes mellitus) and model 3 (model 2 plus excessive weight and obesity, hypertension, hypercholesterolemia, hypertriglyceridemia, family history of CVD and medications they used).


Patients with the lowest eGFR had the lowest HDL values (P = 0.013). In multiple linear regression, HDL was an independent predictor of eGFR (β = 0.189, P = 0.025) which was also shown in multinomial regression for all three models: model 1 [odds ratio (OR) 0.05; 95% confidence interval (CI) 0.007–0.331; P = 0.002], model 2 (OR 0.052; 95% CI 0.006–0.428; P = 0.006) and model 3 (OR 0.2; 95% CI 0.001–0.309; P = 0.005).


Low HDL is an independent predictor of lower eGFR in intermediate and high CVD risk patients without severe kidney disease. In such patients, low HDL could be one of the early indicators of renal failure.

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Correspondence to Domagoj Markovic.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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Markovic, D., Trgo, G., Prkacin, I. et al. The association between high-density lipoproteins and estimated glomerular filtration rate in patients without severe kidney disease. Int Urol Nephrol 50, 1105–1112 (2018). https://doi.org/10.1007/s11255-018-1851-8

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  • Glomerular filtration rate
  • HDL
  • Lipoproteins
  • Risk factors