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International Urology and Nephrology

, Volume 50, Issue 3, pp 411–418 | Cite as

Antiplatelet (aspirin) therapy as a new option in the treatment of vasculogenic erectile dysfunction: a prospective randomized double-blind placebo-controlled study

Urology - Original Paper

Abstract

Purpose

To investigate the efficiency of antiplatelet (aspirin) therapy in vasculogenic erectile dysfunction (VED) patients with a high mean platelet volume.

Methods

A total of 184 patients diagnosed with VED between the ages of 18 and 76 were randomly divided into two groups and treated for 6 weeks [group 1: 120 patients (mean age 48.3), aspirin 100 mg/day; group 2: 64 patients (mean age 47.7), placebo 100 mg/day]. The changes from baseline to end point in erectile function scores on the International Index of Erectile Function (IIEF-EF) and the number of patients who answered “yes” to questions 2 and 3 of the sexual encounter profile (SEP) were compared statistically.

Results

The mean baseline IIEF-EF scores in groups 1 and 2 were 14.1 ± 4.9 and 14.3 ± 5.2, respectively (p = 0.7966), the number of patients who answered “yes” to SEP-2 was 62 (51.6%) in group 1 and 32 (50%) in group 2 (p = 0.8366), and the number of patients who answered “yes” to SEP-3 was 38 (31.6%) in group 1 and 20 (31.2%) in group 2 (p = 0.9557). In the aspirin group, the changes from baseline to end point in the IIEF-EF, SEP-2, and SEP-3 scores were 7.2, 36.6, and 46.6%, respectively. In the placebo group, these changes were 2.0, 9.4, and 12.5%, respectively. When compared with the placebo group, aspirin-treated subjects showed a significant improvement in all three efficacy measures (p < 0.0001).

Conclusions

100 mg of aspirin administered once a day significantly improved EF in men with VED.

Keywords

Aspirin Antiplatelet Antithrombocytic Erectile dysfunction Treatment 

Abbreviations

ASA

Acetylsalicylic acid

CAD

Coronary artery disease

cAMP

Cyclic adenylate monophosphate

cGMP

Cyclic guanylate monophosphate

COX

Prostaglandin H synthase

DUS

Doppler ultrasonography

IIEF

International Index of Erectile Function

MPV

Mean platelet volume

NO

Nitric oxide

PSV

Peak systolic velocity

PAD

Peripheric artery disease

PG

Prostaglandin

SEP

Sexual encounter profile

TxA2

Thromboxane

VED

Vasculogenic erectile dysfunction

Notes

Compliance with ethical standards

Conflict of interest

Both authors declare that they have no conflict of interest.

Ethical standards

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the Declaration of Helsinki (1964) and its later amendments or comparable ethical standards.

Human and animal rights statement

This article does not contain any studies with animals performed by any of the authors.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Copyright information

© Springer Science+Business Media B.V., part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Urology, School of MedicineIstanbul Medipol UniversityPendikTurkey

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