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Association of neutrophil-to-lymphocyte ratio with early renal dysfunction and albuminuria among diabetic patients

  • Ryuichi KawamotoEmail author
  • Daisuke Ninomiya
  • Asuka Kikuchi
  • Taichi Akase
  • Yoshihisa Kasai
  • Tomo Kusunoki
  • Nobuyuki Ohtsuka
  • Teru Kumagi
Nephrology - Original Paper
  • 20 Downloads

Abstract

Purpose

Neutrophil-to-lymphocyte ratio (NLR) was widely studied as a prognostic marker in various medical and surgical specialties, but its significance in diabetic kidney disease is not yet established.

Methods

The subjects comprised 199 men aged 73 ± 11 (mean ± standard deviation) years and 187 women aged 77 ± 10 years from a rural hospital. We examined the relationship between NLR calculated by analyzing differential leukocyte count in complete blood picture and renal function evaluated by estimated glomerular filtration rate (eGFR) using the Modification of Diet in Renal Disease Study Group equation and urinary albumin excretion (UAE).

Results

NLR was negatively related to eGFR and positively related to UAE. Multiple linear regression analysis using eGFR and UAE as an objective variables, adjusted for confounding factors as explanatory variables showed that NLR (β = − 0.101, p = 0.009) as well as age, body mass index, serum uric acid, and presence of uric acid lowing medication were significantly and independently associated with eGFR, and NLR (β = 0.113, p = 0.031) as well as prevalence of cardiovascular disease, systolic blood pressure, presence of antihypertensive medication, presence of antilipidemic medication, and eGFR were significantly and independently associated with UAE. The multivariate-adjusted odds ratios (95% confidence interval) of NLR for stage 3a (eGFR < 60 mL/min/1.73 m2), stage 3b (eGFR < 45 mL/min/1.73 m2), and microalbuminuria (UAE ≥ 30 mg/g Cr) were 1.90 (1.02–3.56) and 2.99 (1.28–6.98), and 1.77 (1.04–3.01), respectively. Next, to examine the consistency of the observed association between NLR and eGFR, we performed subgroup analyses. There was a significant interaction (p = 0.006) only between the two groups regarding antihypertensive medication (absence: β = − 0.272, p < 0.001 and presence: β = − 0.029, p = 0.564).

Conclusions

Our data suggested that NLR might be important as a potential factor for evaluating patients with a higher degree of albuminuria among diabetic outpatients.

Keywords

Neutrophil-to-lymphocyte ratio Estimated glomerular filtration rate Albuminuria Renal dysfunction 

Notes

Acknowledgements

This work was supported in part by a grant-in-aid from the Foundation for Development of Community (2017).

Author’s contributions

RK participated in the design of the study, performed the statistical analysis and drafted the manuscript. RK DN, AK, TA, YK, ToK, NO, and TeK contributed to the acquisition and interpretation of data. RK, DN, and TeK contributed to the conception and design of the statistical analysis. All authors read and approved the manuscript.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no competing interests.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee at which the studies conducted.

Informed consent

We obtained consent through opt-out procedure from all individual participants included in the study.

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Copyright information

© Springer Nature B.V. 2019

Authors and Affiliations

  1. 1.Department of Community MedicineEhime University Graduate School of MedicineToon-cityJapan
  2. 2.Department of Internal MedicineSeiyo Municipal Nomura HospitalSeiyo-cityJapan

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