Anticancer activity of Schiff base–Poloxamer P85 combination against kidney cancer
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Renal cell carcinoma (RCC) accounts for approximately 80% of the primary renal cancers, and current treatment strategies are not sufficient to provide a certain solution. Since there are not many treatment options, interest in discovery of alternative drugs has increased.
In the current study, anticancer activity of a novel heterodinuclear Cu(II)–Mn(II) complex (Schiff base—SB) in combination with poly(ethylene oxide) and poly(propylene oxide) block copolymer (pluronic) P85 was tested against RCC. Cell viability, apoptosis and gene expression analysis were conducted in vitro by using Renca cells.
The results revealed that the SB–P85 combination decreased cell proliferation by increasing the apoptotic gene expressions and apoptosis. Renca-injected BALB/c mice were used to mimic early stage of RCC model. Treatment with SB–P85 combination suppressed tumor formation and growth compared to baseline.
Overall, SB–P85 showed promising anticancer activity against RCC in vitro and in vivo.
KeywordsSchiff base Pluronic P85 Renal cell carcinoma Chemotherapy
This study was supported by İstanbul Kalkınma Ajansı (ISTKA) Project (ISTKA/2012/BIL-164) and Yeditepe University.
Compliance with ethical standards
Conflict of interest
Authors declare that they have no conflict of interest.
Human and animal rights
All applicable international, national, and/or institutional guidelines for the care and use of animals were followed. All experimental procedures were approved by Yeditepe University Ethics Committee of Experimental Animal Use and the Research Scientific Committee (1.4.2013- ISTKA-BIL-164).
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