International Urology and Nephrology

, Volume 50, Issue 1, pp 21–24 | Cite as

Preoperative urine culture is unnecessary in asymptomatic men prior to prostate needle biopsy

  • David Z. Qi
  • Kathleen Lehman
  • Kalyan Dewan
  • Girish Kirimanjeswara
  • Jay D. RamanEmail author
Urology - Original Paper



To determine the clinical utility of preoperative urine cultures in asymptomatic men undergoing prostate needle biopsy (PNB).


One hundred fifty asymptomatic men had urine cultures obtained 14-days prior to PNB. As per study protocol, positive cultures were not treated. Antibiotic prophylaxis prior to PNB included ciprofloxacin 500 mg the night before and morning of the biopsy. Repeat urine cultures were obtained immediately prior to PNB with colony-forming units (CFUs) annotated. Infectious complications post-biopsy were recorded.


Of the 150 men, six patients (4%) had evidence of asymptomatic bacteriuria with > 10,000 CFU/mL on office urine culture. Repeat urine cultures on morning of biopsy in all 150 patients noted a mean bacterial count of 55 CFU/mL (range 0–1000). All six patients with positive office urine cultures had < 100 CFU/mL at time of PNB. Following biopsy, four patients (2.7%) developed an infectious complication including two with sepsis and two with culture-positive UTIs. The causative organism in all cases was quinolone-resistant E. coli. None of the six patients with preoperative positive urine cultures developed an infectious complication following PNB.


In this prospective observational study, under 5% of asymptomatic men had positive office cultures prior to PNB. Furthermore, repeat urine culture on the morning of biopsy showed resolution in these patients, and none developed post-biopsy infectious complications. Routine office urine culture in the asymptomatic male prior to PNB was unnecessary.


Urine culture Bacteriuria Infection Quinolones 


Compliance with ethical standards

Conflict of interest

The authors declare no conflicts of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

Informed consents

Informed consent was obtained from all individual participants included in the study.


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Copyright information

© Springer Science+Business Media B.V., part of Springer Nature 2017

Authors and Affiliations

  • David Z. Qi
    • 1
  • Kathleen Lehman
    • 1
  • Kalyan Dewan
    • 2
  • Girish Kirimanjeswara
    • 2
  • Jay D. Raman
    • 1
    Email author
  1. 1.Division of Urology, Department of Surgery, College of MedicineThe Pennsylvania State UniversityHersheyUSA
  2. 2.Department of Veterinary SciencesThe Pennsylvania State UniversityUniversity ParkUSA

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