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International Urology and Nephrology

, Volume 49, Issue 11, pp 2027–2033 | Cite as

Relationship between plasma pentraxin 3 level and risk of chronic kidney disease in the Korean elderly: the Dong-gu study

  • Ran Lee
  • Min-Ho Shin
  • Hee-Nam Kim
  • Young-Hoon Lee
  • Seong-Woo Choi
  • Hye-Ran Ahn
  • Sun-Seog KweonEmail author
Nephrology – Original Paper
  • 114 Downloads

Abstract

Purpose This study investigated the cross-sectional association between chronic kidney disease (CKD) and plasma pentraxin 3 (PTX3) levels in a Korean population, in a community-based cohort study.

Methods

A total of 1816 (891 men, 925 women) subjects were randomly selected from the cohort of participants for the final analyses. Plasma PTX3 concentration was determined using enzyme-linked immunosorbent assays. The participants were divided into four quartiles according to the PTX3 levels. Multivariate logistic regression was performed to evaluate the association between plasma PTX3 level and CKD. Covariates inserted into the multivariate model included smoking status, systolic blood pressure, body mass index, waist circumference, high-density lipoprotein, low-density lipoprotein uric acid, white blood cell count, and carotid intima-media thickness.

Results

Compared to the lowest PTX3 group (Q1), a significantly higher risk of CKD was found in the highest group (Q4), with an odds ratio of 1.58 and 95% confidence interval of 1.18–2.11 (P for trend <0.001).

Conclusions

This study showed that higher plasma PTX3 levels are significantly associated with CKD risk. The biological mechanism remains unclear; therefore, further molecular investigation of association between CKD and PTX3 is needed.

Keywords

Pentraxin 3 Chronic kidney disease Community-based study 

Notes

Compliance with ethical standards

Conflict of interest

All authors declare that he/she has no conflict of interests regarding the publication of this paper.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. This study was approved by Institutional Review Board of Chonnam National University Hospital.

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Copyright information

© Springer Science+Business Media B.V. 2017

Authors and Affiliations

  • Ran Lee
    • 1
  • Min-Ho Shin
    • 1
    • 2
  • Hee-Nam Kim
    • 2
  • Young-Hoon Lee
    • 3
  • Seong-Woo Choi
    • 4
  • Hye-Ran Ahn
    • 5
  • Sun-Seog Kweon
    • 1
    • 6
    Email author
  1. 1.Department of Preventive MedicineChonnam National University Medical SchoolGwangjuKorea
  2. 2.Center for Creative Biomedical ScientistsChonnam National UniversityGwangjuKorea
  3. 3.Department of Preventive Medicine and Institute of Wonkwang Medical ScienceWonkwang University College of MedicineIksanKorea
  4. 4.Department of Preventive MedicineChosun University Medical SchoolGwangjuKorea
  5. 5.Department of NursingNambu UniversityGwangjuKorea
  6. 6.Jeonnam Regional Cancer CenterChonnam National University Hwasun HospitalHwasunKorea

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