International Urology and Nephrology

, Volume 49, Issue 5, pp 859–865 | Cite as

Effect of serum albumin on the prognosis of elderly patients with stage 3–4 chronic kidney disease

  • Hongru Fan
  • Jihong YangEmail author
  • Lili Liu
  • Yu Qiao
  • Meng Wang
  • Lei Qiu
  • Hong Shi
  • Huan Xi
  • Yao Wang
Nephrology - Original Paper



To investigate the influence of serum albumin on the prognosis of elderly patients with stage 3–4 chronic kidney disease (CKD).


From July 2013 to November 2015, elderly CKD patients (≥60 years), with eGFR ≥15 mL/min/1.73 m2 and <60 mL/min/1.73 m2, with CKD stage 3–4 in the geriatric nephrology clinic were enrolled. General information and underlying diseases were recorded. Laboratory indices were evaluated. Composite endpoint events (CEE) including renal endpoint events, cardiocerebral vascular endpoint events, and death were elucidated. Based on the ROC curves, the patients were divided into lower and higher serum albumin groups (<42.5 and ≥42.5 g/L).


The occurrence of CEEs was significantly higher in lower serum albumin group than those in the higher group. Also, the patients in the higher group were significantly younger with lower urinary protein, blood urea, brain natriuretic peptide, and cystatin C than those in the lower serum albumin group. Contrastingly, hemoglobin, total serum protein, serum calcium, and superoxide dismutase were remarkably higher. The composite endpoints of multifactor logistic regression analysis indicated that as the serum albumin is increased by every 1 g/L, the probability of CEEs would reduce 14.8%, and the risk occurrence rate of the lower serum albumin group was 4.739 fold than the higher group.


The results suggest that patients with higher serum albumin had a better prognosis than those with lower serum albumin. The low level was an independent risk factor influencing the prognosis of elderly patients in stage 3–4 CKD.


Serum albumin Elderly patients CKD Prognosis 



This study was supported in part by the Capital Health Project Beijing Science Committee (Grant No: Z131100004013042) and Ministry of Human Resource of China (Grant No. bj201335) both to Dr. Jihong Yang.

Compliance with ethical standards

Conflict of interest

The authors state that they have no conflicts of interest.


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Copyright information

© Springer Science+Business Media Dordrecht 2017

Authors and Affiliations

  • Hongru Fan
    • 1
  • Jihong Yang
    • 1
    Email author
  • Lili Liu
    • 1
  • Yu Qiao
    • 1
  • Meng Wang
    • 1
  • Lei Qiu
    • 1
  • Hong Shi
    • 1
  • Huan Xi
    • 1
  • Yao Wang
    • 1
  1. 1.Department of Geriatric MedicineBeijing Hospital, National Center of GerontologyBeijingPeople’s Republic of China

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