Few contemporary studies have evaluated the clinical characteristics of patients with biopsy-proven glomerulopathy diagnosed with renal vein thrombosis (RVT).
Retrospective case series study within an integrated health system in a 12-year period (January 1, 2000 through December 31, 2011) investigating clinical characteristics of all adult patients who underwent native or transplant kidney biopsy and also had a diagnosis of RVT. Patient characteristics, diagnostic studies, and outcomes were evaluated.
Among 3763 eligible patients, 17 had imaging confirmed RVT. Of these, 15 had membranous nephropathy (idiopathic or secondary to autoimmune disease). Although the biopsy population included primary and secondary glomerular disease patients, all 17 RVT patients had severe nephrotic syndrome and profound hypoalbuminemia with mean (SD) of albumin: 1.5 g/dL (0.66).
Clinically significant RVT in patients with glomerulopathy appears to be a rather rare entity, occurring predominantly in patients with severe nephrotic syndrome due to idiopathic membranous nephropathy and membranous nephropathy secondary to autoimmune disease.
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This study was funded in part by the Kaiser Permanente Southern California Clinical Investigator Award and by an investigator initiated research Grant (JJS PI) from Autoimmune and Rare Diseases of Mallinckrodt Pharmaceuticals.
Conflict of interest
John J. Sim has received research Grants from Mallinckrodt Pharmaceuticals, Keryx Pharmaceuticals, Sanofi Aventis Pharmaceuticals, and Otsuka Pharmaceuticals. No other authors have any conflict of interest to declare.
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. This article does not contain any studies with animals performed by any of the authors.
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Ross, O., Pourmoussa, A., Batech, M. et al. Characteristics of patients diagnosed with renal vein thrombosis and glomerulopathy: a case series. Int Urol Nephrol 49, 285–293 (2017). https://doi.org/10.1007/s11255-016-1442-5
- Renal vein thrombosis
- Nephrotic syndrome
- Membranous nephropathy