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Vitamin D3 deficiency is associated with female sexual dysfunction in premenopausal women

  • Urology - Original Paper
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Abstract

Purpose

To assess female sexual functions in women who were affected by vitamin D3 deficiency.

Methods

A total of 50 women with FSD and 58 healthy women controls were included in the study, according to the Female Sexual Function Index (FSFI) questionnaire using a 26.55 cutoff value. Detailed medical histories were obtained from all sexual active women, and all women were evaluated in terms of possible presence of depression with the Beck Depression Inventory (BDI). Serum 25-hydroxyvitamin D3, follicle-stimulating hormone (FSH), luteinizing hormone (LH), prolactin, total and free testosterone, estradiol, dehydroepiandrosterone-SO4 (DHEA-SO4), sex hormone-binding globulin (SHBG), free thyroxine (fT4), and thyroid-stimulating hormone (TSH) levels were measured.

Results

Mean age of premenopausal women was 34.9 ± 6.3 years. The level of serum 25-hydroxyvitamin D3 was significantly lower in women with FSD compared with the controls (15.9 ± 8.4 and 26.3 ± 11.7 nmol/L, respectively). Desire (p = 0.0001), arousal (p = 0.0001), lubrication (p = 0.002), orgasm (p = 0.0001), satisfaction (p = 0.018), and pain (p = 0.010) domain scores were also correlated with the levels of serum 25-hydroxyvitamin D3. The BDI score showed a significant negative correlation with the total FSFI score (r = −0.492, p = 0.0001). The FSFI score not showed a significant correlation with the hormones (p > 0.05).

Conclusion

There is a relationship with FSD and deficiency of vitamin D3. Also, increased depressive symptoms were associated with FSD.

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Funding

This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.

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Authors and Affiliations

  1. Endocrinology Department, Şişli Etfal Training and Research Hospital, 34371, Şişli/Istanbul, Turkey

    Masum Canat, Feyza Yener Öztürk, Hatice Eroğlu & Yüksel Altuntaş

  2. Urology Department, Okmeydanı Training and Research Hospital, Şişli, Istanbul, Turkey

    Lütfi Canat & Hasan Anıl Atalay

  3. Internal Medicine Department, Şişli Etfal Training and Research Hospital, Istanbul, Turkey

    Hatice Eroğlu

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  1. Masum Canat
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  2. Lütfi Canat
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Correspondence to Masum Canat.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. The study was approved by the local committee of ethics.

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Informed consent was obtained from all individual participants included in the study.

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Canat, M., Canat, L., Öztürk, F.Y. et al. Vitamin D3 deficiency is associated with female sexual dysfunction in premenopausal women. Int Urol Nephrol 48, 1789–1795 (2016). https://doi.org/10.1007/s11255-016-1396-7

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  • DOI: https://doi.org/10.1007/s11255-016-1396-7

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