Previous clinical studies have shown that the circulating level of endostatin is related to kidney injury. We hypothesized that the impact of HbA1c, fasting, and postprandial plasma glucose on urinary albumin excretion would be related to the serum endostatin level.
A cross-sectional, community-based population study of 1057 Japanese residents was conducted. Of these subjects, 162 with a fasting plasma glucose value between 5.5 and 6.9 mmol/L and an HbA1c level of <6.5 % received an oral glucose tolerance test, had serum endostatin measured, and had the urinary albumin/creatinine ratio (UACR) calculated.
In multivariate analysis, 2-h postprandial plasma glucose (β = 0.26, P < 0.01) was significantly associated with log-transformed UACR, independently of fasting plasma glucose (β = 0.14, P = 0.28) and HbA1c (β = −0.08, P = 0.57). When divided by the median value of endostatin (82.2 ng/mL), 2-h postprandial plasma glucose (β = 0.38, P = 0.01) remained significantly associated with the log-transformed UACR of the participants below the median, while the fasting plasma glucose (β = 0.34, P = 0.046) was independently associated with the log-transformed UACR of participants above the median.
Postprandial plasma glucose was independently associated with the urinary albumin excretion of the residents with prediabetes. Moreover, this relationship was limited to residents with a serum endostatin level below the median.
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We are grateful to Drs. Kyoko Okada, Sakiko Hayasaki, Ayaka Komori, Rinne Takeda, Sho Yamasaki, Azusa Hatashima, and Masaru Sakiyama from our department for their assistance.
This study was funded by the Japan Multi-institutional Collaborative Cohort Study (J-MICC Study), a Scientific Support Programs for Cancer Research Grant-in-Aid for Scientific Research on Innovative Areas (Grant Number 221S0001), and a Grant-in-Aid for Comprehensive Research (Priority Areas of Cancer: Grant Number 17015018) of the 21st Century COE Program from the Ministry of Education, Culture, Sports Science, and Technology of Japan. This research was partially supported by Ministry of Education, Science, Sports and Culture, Grant-in-Aid for Scientific Research (C), 2014-2016 (26461506, Norihiro Furusyo).
Conflict of interest
Norihiro Furusyo has received grants from Taisho Toyama Pharmaceutical Co., Ltd., Daiichi Sankyo Co., Ltd., and Bristol-Myers Squibb. The other authors declare that they have no conflicts of interest.
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.
Informed consent was obtained from all individual participants included in the study.
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Shimizu, M., Furusyo, N., Tanaka, Y. et al. The relation of postprandial plasma glucose and serum endostatin to the urinary albumin excretion of residents with prediabetes: results from the Kyushu and Okinawa Population Study (KOPS). Int Urol Nephrol 48, 851–857 (2016). https://doi.org/10.1007/s11255-016-1258-3
- Diabetic nephropathy
- Postprandial plasma glucose
- Serum endostatin
- Urinary albumin excretion