International Urology and Nephrology

, Volume 46, Issue 10, pp 1997–2002

Effect of continuous positive airway pressure on serum cystatin C among obstructive sleep apnea syndrome patients

  • Xiao-Bin Zhang
  • Xing-Tang Jiang
  • Qi-Chang Lin
  • Xiao Chen
  • Hui-Qing Zeng
Nephrology - Original Paper

DOI: 10.1007/s11255-014-0779-x

Cite this article as:
Zhang, XB., Jiang, XT., Lin, QC. et al. Int Urol Nephrol (2014) 46: 1997. doi:10.1007/s11255-014-0779-x

Abstract

Purpose

The purpose of the present study was to evaluate the influence of continuous positive airway pressure (CPAP) on serum cystatin C, a novel biomarker of early renal impairment, among obstructive sleep apnea (OSA) patients.

Materials and methods

Newly diagnosed severe OSA patients who treated with CPAP for 3 months were enrolled from two sleep laboratories. Serum biomarkers of renal impairment, cystatin C, creatinine and estimated glomerular filtration rate (eGFR), were detected before and after CPAP treatment.

Results

A total of 39 severe OSA patients were enrolled, 29 (74.4 %) were male, and mean age was 51.2 ± 12.2 years. After CPAP treatment, there were no changes of creatinine and eGFR (77.80 ± 20.00 vs. 75.3 ± 16.60 and 98.69 ± 31.74 vs. 100.20 ± 28.30, all p > 0.05), but cystatin C declined significantly (0.87 ± 0.18 vs. 0.77 ± 0.21, p = 0.000).

Conclusion

CPAP can decrease cystatin C levels among severe OSA patients and may prevent the latent renal impairment.

Keywords

Obstructive sleep apnea Cystatin C Continuous positive airway Renal impairment 

Copyright information

© Springer Science+Business Media Dordrecht 2014

Authors and Affiliations

  • Xiao-Bin Zhang
    • 1
  • Xing-Tang Jiang
    • 1
  • Qi-Chang Lin
    • 2
  • Xiao Chen
    • 2
  • Hui-Qing Zeng
    • 1
  1. 1.Department of Respiratory Medicine, Zhongshan HospitalXiamen UniversityXiamenPeople’s Republic of China
  2. 2.Department of Respiratory MedicineThe First Affiliated Hospital of Fujian Medical UniversityFuzhouPeople’s Republic of China

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