International Urology and Nephrology

, Volume 46, Issue 9, pp 1779–1784 | Cite as

Environmental and stressful factors affecting the occurrence of kidney stones and the kidney colic

  • Rigas G. Kalaitzidis
  • Dimitrios Damigos
  • Kostas C. Siamopoulos
Nephrology - Review


The first renal disease described from Hippocrates is nephrolithiasis with renal colic, which is the pain of stone passage and is also a common renal problem with easily recognizable characteristics. There has been much written about dietary factors, which have unequivocally been proved to play an important role in the formation of kidney stones. In this regard, it is of interest that the contribution of factors such as stressful events, life style, or occupation in the formation of kidney stones has not been well studied. This review examines the clinical evidence of the stressful events and other environmental factors affecting the occurrence of kidney stones.


Kidney stones Nephrolithiasis Stressful events Renal colic 


Conflict of interest

The authors declare that they have no conflict of interest.


  1. 1.
    Pak CY, Resnick MI, Preminger GM (1997) Ethnic and geographic diversity of stone disease. Urology 50:504–507PubMedCrossRefGoogle Scholar
  2. 2.
    Consensus conference (1988) Prevention and treatment of kidney stones. JAMA 260:977–981CrossRefGoogle Scholar
  3. 3.
    Dardioti V, Angelopoulos N, Hadjiconstantinou V (1997) Renal diseases in the Hippocratic era. Am J Nephrol 17:214–216PubMedCrossRefGoogle Scholar
  4. 4.
    Saitoh H (2005) Descriptions of urinary stone in the Hippocratic collection. Nihon Hinyokika Gakkai Zasshi 96:632–639PubMedGoogle Scholar
  5. 5.
    Gorgieva GS (2006) Kidney disease in medieval Serbian manuscripts from the Chilandar monastery (Mount Athos, Greece). J Nephrol Suppl 10:S30–S37Google Scholar
  6. 6.
    Roberson JW (1978) A view from Oklahoma, 1866–1868: the diary and letters of Dr. James Reagles, Jr., Assistant Surgeon, U. S Army. Red River Val Hist Rev 3:19–46PubMedGoogle Scholar
  7. 7.
    Parks JH, Coe FL, Strauss AL (1982) Calcium nephrolithiasis and medullary sponge kidney in women. N Engl J Med 306:1088–1091PubMedCrossRefGoogle Scholar
  8. 8.
    Coe FL, Keck J, Norton ER (1977) The natural history of calcium urolithiasis. JAMA 238:1519–1523PubMedCrossRefGoogle Scholar
  9. 9.
    Soucie JM, Thun MJ, Coates RJ, McClellan W, Austin H (1994) Demographic and geographic variability of kidney stones in the United States. Kidney Int 46:893–899PubMedCrossRefGoogle Scholar
  10. 10.
    Soucie JM, Coates RJ, McClellan W, Austin H, Thun M (1996) Relation between geographic variability in kidney stones prevalence and risk factors for stones. Am J Epidemiol 143:487–495PubMedCrossRefGoogle Scholar
  11. 11.
    Levy FL, Adams-Huet B, Pak CY (1995) Ambulatory evaluation of nephrolithiasis: an update of a 1980 protocol. Am J Med 98:50–59PubMedCrossRefGoogle Scholar
  12. 12.
    Sierakowski R, Finlayson B, Landes RR, Finlayson CD, Sierakowski N (1978) The frequency of urolithiasis in hospital discharge diagnoses in the United States. Invest Urol 15:438–441PubMedGoogle Scholar
  13. 13.
    Johnson CM, Wilson DM, O’Fallon WM, Malek RS, Kurland LT (1979) Renal stone epidemiology: a 25-year study in Rochester, Minnesota. Kidney Int 16:624–631PubMedCrossRefGoogle Scholar
  14. 14.
    Goldfarb S (1988) Dietary factors in the pathogenesis and prophylaxis of calcium nephrolithiasis. Kidney Int 34:544–555PubMedCrossRefGoogle Scholar
  15. 15.
    Grossman HB, Sommerfield D, Konnak JW, Bromberg J (1994) Long-term assessment of renal function following nephrectomy for stage I renal carcinoma. Br J Urol 74:279–282PubMedCrossRefGoogle Scholar
  16. 16.
    Ettinger B (1979) Recurrence of nephrolithiasis: a six-year prospective study. Am J Med 67:245–248PubMedCrossRefGoogle Scholar
  17. 17.
    Ljunghall S, Backman U, Danielson BG, Fellstrom B, Johansson G, Wikstrom B (1980) Epidemiological aspects of renal stone disease in Scandinavia. Scand J Urol Nephrol Suppl 53:31–38Google Scholar
  18. 18.
    Ljunghall S, Danielson BG (1984) A prospective study of renal stone recurrences. Br J Urol 56:122–124PubMedCrossRefGoogle Scholar
  19. 19.
    Sutherland JW, Parks JH, Coe FL (1985) Recurrence after a single renal stone in a community practice. Miner Electrolyte Metab 11:267–269PubMedGoogle Scholar
  20. 20.
    Shuster J, Jenkins A, Logan C et al (1992) Soft drink consumption and urinary stone recurrence: a randomized prevention trial. J Clin Epidemiol 45:911–916PubMedCrossRefGoogle Scholar
  21. 21.
    Frank M, de Vries A, Atsmon A, Lazebnik J, Kochwa S (1959) Epidemiological investigation of urolithiasis in Israel. J Urol 81:497–505PubMedGoogle Scholar
  22. 22.
    Srivastava A, Bansal R, Srivastava A et al (2012) Percutaneous nephrolithotomy in polycystic kidney disease: is it safe and effective? Int Urol Nephrol 44:725–730PubMedCrossRefGoogle Scholar
  23. 23.
    Chua ME, Gatchalian GT, Corsino MV, Reyes BB (2012) Diagnostic utility of attenuation measurement (Hounsfield units) in computed tomography stonogram in predicting the radio-opacity of urinary calculi in plain abdominal radiographs. Int Urol Nephrol 44:1349–1355PubMedCrossRefGoogle Scholar
  24. 24.
    Andersen DA (1966) A survey of the incidence of urolithiasis in Norway from 1853 to 1960. J Oslo City Hosp 16:101–147PubMedGoogle Scholar
  25. 25.
    Sallinen A (1959) The relation of renal colic to urolithiasis. Ann Chir Gynaecol Fenn 48:473–489PubMedGoogle Scholar
  26. 26.
    Pierce LW, Bloom B (1945) Observations on urolithiasis among American troops in a desert area. J Urol 54:466–470PubMedGoogle Scholar
  27. 27.
    Ferrie BG, Scott R (1984) Occupation and urinary tract stone disease. Urology 24:443–445PubMedCrossRefGoogle Scholar
  28. 28.
    Borghi L, Meschi T, Amato F, Novarini A, Romanelli A, Cigala F (1993) Hot occupation and nephrolithiasis. J Urol 150:1757–1760PubMedGoogle Scholar
  29. 29.
    Larsen JF, Philip J (1962) Studies on the incidence of urolithiasis. Urol Int 13:53–64PubMedCrossRefGoogle Scholar
  30. 30.
    Bakkaloglu MA, Erkan I, Ozen HA, Remzi D (1984) A study on the prevalence of urolithiasis among Turkish medical doctors. Turk J Pediatr 26:5–9PubMedGoogle Scholar
  31. 31.
    Kohler FP (1961) Asymptomatic upper urinary tract lithiasis in flying personnel. J Urol 86:370–372PubMedGoogle Scholar
  32. 32.
    Scott R, Cunningham C, McLelland A, Fell GS, Fitzgerald-Finch OP, McKellar N (1982) The importance of cadmium as a factor in calcified upper urinary tract stone disease: a prospective 7-year study. Br J Urol 54:584–589PubMedCrossRefGoogle Scholar
  33. 33.
    Lappalainen R, Sairanen E, Jarvela E et al (2014) The effectiveness and applicability of different lifestyle interventions for enhancing wellbeing: the study design for a randomized controlled trial for persons with metabolic syndrome risk factors and psychological distress. BMC Public Health 14:310PubMedCentralPubMedCrossRefGoogle Scholar
  34. 34.
    Walters DC (1986) Stress as a principal cause of calcium oxalate urolithiasis. Int Urol Nephrol 18:271–275PubMedCrossRefGoogle Scholar
  35. 35.
    Kohri K, Kataoka K, Iguchi M, Yachiku S, Kurita T, Sonoda T (1984) Relation between parathyroid hormone and adrenocorticotropic hormone in primary hyperparathyroidism. Urol Int 39:1–4PubMedCrossRefGoogle Scholar
  36. 36.
    Najem GR, Seebode JJ, Samady AJ, Feuerman M, Friedman L (1997) Stressful life events and risk of symptomatic kidney stones. Int J Epidemiol 26:1017–1023PubMedCrossRefGoogle Scholar
  37. 37.
    Jiang P, Zhang WY, Li HD, Cai HL, Liu YP, Chen LY (2013) Stress and vitamin D: altered vitamin D metabolism in both the hippocampus and myocardium of chronic unpredictable mild stress exposed rats. Psychoneuroendocrinology 38:2091–2098PubMedCrossRefGoogle Scholar
  38. 38.
    Pipili C, Oreopoulos DG (2013) Vitamin D status in patients with recurrent kidney stones. Nephron Clin Pract 122:134–138CrossRefGoogle Scholar
  39. 39.
    Bilic V, Marcinko D (2010) Comorbidity of kidney stones and psychiatric disease. Psychiatr Danub 22:249–252PubMedGoogle Scholar
  40. 40.
    Diniz DH, Schor N, Blay SL (2006) Stressful life events and painful recurrent colic of renal lithiasis. J Urol 176:2483–2487PubMedCrossRefGoogle Scholar
  41. 41.
    Sfoungaristos S, Kavouras A, Perimenis P (2012) Predictors for spontaneous stone passage in patients with renal colic secondary to ureteral calculi. Int Urol Nephrol 44:71–79PubMedCrossRefGoogle Scholar
  42. 42.
    Badawy AA, Saleem MD, Abolyosr A et al (2012) Extracorporeal shock wave lithotripsy as first line treatment for urinary tract stones in children: outcome of 500 cases. Int Urol Nephrol 44:661–666PubMedCrossRefGoogle Scholar
  43. 43.
    Pevzner M, Stisser BC, Luskin J, Yeamans JC, Cheng-Lucey M, Pahira JJ (2011) Alternative management of complex renal stones. Int Urol Nephrol 43:631–638PubMedCrossRefGoogle Scholar
  44. 44.
    Frischknecht U, Sabo T, Mann K (2013) Improved drinking behaviour improves quality of life: a follow-up in alcohol-dependent subjects 7 years after treatment. Alcohol Alcohol 48:579–584PubMedCrossRefGoogle Scholar
  45. 45.
    Fakheri RJ, Goldfarb DS (2011) Ambient temperature as a contributor to kidney stone formation: implications of global warming. Kidney Int 79:1178–1185PubMedCrossRefGoogle Scholar
  46. 46.
    Robertson WG, Peacock M, Marshall RW, Speed R, Nordin BE (1975) Seasonal variations in the composition of urine in relation to calcium stone-formation. Clin Sci Mol Med 49:597–602PubMedGoogle Scholar
  47. 47.
    Eisner BH, Sheth S, Herrick B et al (2012) The effects of ambient temperature, humidity and season of year on urine composition in patients with nephrolithiasis. BJU Int 110:E1014–E1017PubMedCrossRefGoogle Scholar
  48. 48.
    Bateson EM (1973) Renal tract calculi and climate. Med J Aust 2:111–113PubMedGoogle Scholar
  49. 49.
    Parry ES, Lister IS (1975) Sunlight and hypercalciuria. Lancet 1:1063–1065PubMedCrossRefGoogle Scholar
  50. 50.
    Power C, Barker DJ, Blacklock NJ (1987) Incidence of renal stones in 18 British towns: a collaborative study. Br J Urol 59:105–110PubMedCrossRefGoogle Scholar
  51. 51.
    Mosli HA, Mosli HH, Kamal WK (2013) Kidney stone composition in overweight and obese patients: a preliminary report. Res Rep Urol 5:11–15PubMedCentralPubMedGoogle Scholar
  52. 52.
    Ulmann A, Aubert J, Bourdeau A, Cheynel C, Bader C (1982) Effects of weight and glucose ingestion on urinary calcium and phosphate excretion: implications for calcium urolithiasis. J Clin Endocrinol Metab 54:1063–1068PubMedCrossRefGoogle Scholar
  53. 53.
    Curhan GC, Willett WC, Rimm EB, Speizer FE, Stampfer MJ (1998) Body size and risk of kidney stones. J Am Soc Nephrol 9:1645–1652PubMedGoogle Scholar
  54. 54.
    Wasserstein AG, Stolley PD, Soper KA, Goldfarb S, Maislin G, Agus Z (1987) Case–control study of risk factors for idiopathic calcium nephrolithiasis. Miner Electrolyte Metab 13:85–95PubMedGoogle Scholar
  55. 55.
    Trinchieri A, Mandressi A, Luongo P, Longo G, Pisani E (1991) The influence of diet on urinary risk factors for stones in healthy subjects and idiopathic renal calcium stone formers. Br J Urol 67:230–236PubMedCrossRefGoogle Scholar
  56. 56.
    Heilberg IP, Goldfarb DS (2013) Optimum nutrition for kidney stone disease. Adv Chronic Kidney Dis 20:165–174PubMedCrossRefGoogle Scholar
  57. 57.
    Pigna F, Sakhaee K, Adams-Huet B, Maalouf NM (2014) Body fat content and distribution and urinary risk factors for nephrolithiasis. Clin J Am Soc Nephrol 9:159–165PubMedCrossRefGoogle Scholar
  58. 58.
    Whiting SJ, Draper HH (1980) The role of sulfate in the calciuria of high protein diets in adult rats. J Nutr 110:212–222PubMedGoogle Scholar
  59. 59.
    Dogliotti E, Vezzoli G, Nouvenne A et al (2013) Nutrition in calcium nephrolithiasis. J Transl Med 11:109PubMedCentralPubMedCrossRefGoogle Scholar
  60. 60.
    Goktas C, Horuz R, Akca O et al (2012) The effect of citrate replacement in hypocitraturic cases on the results of SWL: a preliminary prospective randomized study. Int Urol Nephrol 44:1357–1362PubMedCrossRefGoogle Scholar
  61. 61.
    Schwen ZR, Riley JM, Shilo Y, Averch TD (2013) Dietary management of idiopathic hyperoxaluria and the influence of patient characteristics and compliance. Urology 82:1220–1225PubMedCrossRefGoogle Scholar
  62. 62.
    Strauss AL, Coe FL, Deutsch L, Parks JH (1982) Factors that predict relapse of calcium nephrolithiasis during treatment: a prospective study. Am J Med 72:17–24PubMedCrossRefGoogle Scholar
  63. 63.
    Borghi L, Meschi T, Amato F, Briganti A, Novarini A, Giannini A (1996) Urinary volume, water and recurrences in idiopathic calcium nephrolithiasis: a 5-year randomized prospective study. J Urol 155:839–843PubMedCrossRefGoogle Scholar
  64. 64.
    Coe FL, Parks JH, Asplin JR (1992) The pathogenesis and treatment of kidney stones. N Engl J Med 327:1141–1152PubMedCrossRefGoogle Scholar
  65. 65.
    Lotan Y, Buendia J, Lenoir-Wijnkoop I et al (2012) Primary prevention of nephrolithiasis is cost-effective for a national healthcare system. BJU Int 110:E1060–E1067PubMedCrossRefGoogle Scholar
  66. 66.
    Curhan GC, Willett WC, Rimm EB, Stampfer MJ (1993) A prospective study of dietary calcium and other nutrients and the risk of symptomatic kidney stones. N Engl J Med 328:833–838PubMedCrossRefGoogle Scholar
  67. 67.
    Curhan GC, Willett WC, Speizer FE, Spiegelman D, Stampfer MJ (1997) Comparison of dietary calcium with supplemental calcium and other nutrients as factors affecting the risk for kidney stones in women. Ann Intern Med 126:497–504PubMedCrossRefGoogle Scholar
  68. 68.
    Curhan GC, Willett WC, Speizer FE, Stampfer MJ (1998) Beverage use and risk for kidney stones in women. Ann Intern Med 128:534–540PubMedCrossRefGoogle Scholar
  69. 69.
    Massey LK, Sutton RA (1993) Modification of dietary oxalate and calcium reduces urinary oxalate in hyperoxaluric patients with kidney stones. J Am Diet Assoc 93:1305–1307PubMedCrossRefGoogle Scholar
  70. 70.
    Lown KS, Bailey DG, Fontana RJ et al (1997) Grapefruit juice increases felodipine oral availability in humans by decreasing intestinal CYP3A protein expression. J Clin Invest 99:2545–2553PubMedCentralPubMedCrossRefGoogle Scholar
  71. 71.
    Caudarella R, Rizzoli E, Buffa A, Bottura A, Stefoni S (1998) Comparative study of the influence of 3 types of mineral water in patients with idiopathic calcium lithiasis. J Urol 159:658–663PubMedCrossRefGoogle Scholar
  72. 72.
    Gaches GC, Gordon IR, Shore DF, Roberts JB (1975) Urinary lithiasis in childhood in the Bristol clinical area. Br J Urol 47:109–116PubMedCrossRefGoogle Scholar
  73. 73.
    Lotan Y (2009) Economics and cost of care of stone disease. Adv Chronic Kidney Dis 16:5–10PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media Dordrecht 2014

Authors and Affiliations

  • Rigas G. Kalaitzidis
    • 1
  • Dimitrios Damigos
    • 2
  • Kostas C. Siamopoulos
    • 1
    • 3
  1. 1.Outpatient Renal and Hypertension ClinicUniversity Hospital of IoanninaIoanninaGreece
  2. 2.Department of Psychiatry, School of Health SciencesUniversity of IoanninaIoanninaGreece
  3. 3.Division of Nephrology, Department of Internal Medicine, Faculty of Medicine, School of Health SciencesUniversity of IoanninaIoanninaGreece

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