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Hydroxyurea therapy for priapism prevention and erectile function recovery in sickle cell disease: a case report and review of the literature

Abstract

Prolonged ischemic priapism in patients with sickling hemoglobinopathies is a urologic emergency requiring immediate intervention to avoid irreversible anoxic penile injury, corporal fibrosis, and erectile dysfunction. Therapeutic options, however, are limited and often ineffective. Here, we report recovery of erectile function with hydroxyurea therapy in an adolescent with hemoglobin SS following a prolonged episode of priapism and subsequent severe erectile dysfunction. This case suggests a potential role of hydroxyurea in reversing end organ damage in patients with hemoglobin SS and also supports basic science work indicating involvement of the NO-dependent pathway in the pathogenesis of sickle cell disease-associated priapism.

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Conflict of interest

None.

Author information

Correspondence to Arthur L. Burnett.

Additional information

Uzoma A. Anele and A. Kyle Mack have contributed equally to this work.

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Anele, U.A., Kyle Mack, A., Resar, L.M.S. et al. Hydroxyurea therapy for priapism prevention and erectile function recovery in sickle cell disease: a case report and review of the literature. Int Urol Nephrol 46, 1733–1736 (2014). https://doi.org/10.1007/s11255-014-0737-7

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Keywords

  • Priapism
  • Impotence
  • Hydroxyurea
  • Sickle cell anemia