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International Urology and Nephrology

, Volume 46, Issue 4, pp 781–786 | Cite as

Prevention of contrast-induced nephropathy with prostaglandin E1 in high-risk patients undergoing percutaneous coronary intervention

  • Wen-Hua Li
  • Dong-Ye Li
  • Wen-Hao Qian
  • Jia-Li Liu
  • Tong-Da Xu
  • Hong Zhu
  • Hai-Yan He
Nephrology - Original Paper

Abstract

Purpose

Contrast-induced nephropathy (CIN) is an important complication in the use of iodinated contrast media. The present study aimed to assess the safety and efficacy of prostaglandin E1 (PGE1) in prevention of CIN in patients with high-risk factors undergoing percutaneous coronary intervention (PCI).

Methods

The study group consisted of 163 patients who had undergone a coronary intervention procedure between January 1, 2012 and October 31, 2012. Study participants were randomly assigned to either the PGE1 group (82 patients) or the control group (81 patients). Patients in the PGE1 group received PGE1 intravenous infusion of 20 ng/kg/min for 6 h before and after the administration of contrast media. The control group received 0.9 % sodium chloride solution for routine hydration only. A nonionic, low-osmolality contrast agent was used in our laboratory at this time. Serum creatinine (Scr) values and estimated glomerular filtration rate were measured before and within 48 h of the administration of contrast agents. CIN was defined as an increase of ≥0.5 mg/dL or ≥ a 25 % increase in Scr concentrations over baseline within 48 h of angiography.

Results

The amount of contrast agent administered was similar for the PGE1 and control groups (156 ± 63 vs. 161 ± 68 mL, P > 0.05). The incidence of CIN was lower in the PGE1 group than in the control group (3.7 vs. 11.1 %, P < 0.05). No serious adverse effects were observed.

Conclusions

In patients with high-risk factors undergoing PCI, the use of PGE1 for prevention of CIN is safe and efficacious.

Keywords

Contrast-induced nephropathy Prostaglandin E1 Primary prevention Percutaneous coronary intervention 

Notes

Acknowledgments

This study was supported by the Xuzhou Medical College Science Foundation.

Conflict of interest

None.

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Copyright information

© Springer Science+Business Media Dordrecht 2014

Authors and Affiliations

  • Wen-Hua Li
    • 1
  • Dong-Ye Li
    • 1
  • Wen-Hao Qian
    • 1
  • Jia-Li Liu
    • 1
  • Tong-Da Xu
    • 1
  • Hong Zhu
    • 1
  • Hai-Yan He
    • 1
  1. 1.Department of CardiologyAffiliated Hospital of XuZhou Medical CollegeXuzhouChina

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