International Urology and Nephrology

, Volume 46, Issue 4, pp 711–717

The Prostate Health Index in predicting initial prostate biopsy outcomes in Asian men with prostate-specific antigen levels of 4–10 ng/mL

  • C. F. Ng
  • Peter K. F. Chiu
  • N. Y. Lam
  • H. C. Lam
  • Kim W. M. Lee
  • Simon S. M. Hou
Urology - Original Paper

DOI: 10.1007/s11255-013-0582-0

Cite this article as:
Ng, C.F., Chiu, P.K.F., Lam, N.Y. et al. Int Urol Nephrol (2014) 46: 711. doi:10.1007/s11255-013-0582-0

Abstract

Purpose

To investigate the role of the Prostate Health Index (phi) in prostate cancer (PCa) detection in patients with a prostate-specific antigen (PSA) level of 4–10 ng/mL receiving their first prostatic biopsy in an Asian population.

Methods

This was a retrospective study of archived serum samples from patients enlisted in our tissue bank. Patients over 50 years old, with PSA level of 4–10 ng/mL, a negative digital rectal examination, and received their first prostatic biopsy between April 2008 and April 2013, were recruited. The serum sample collected before biopsy was retrieved for the measurement of various PSA derivatives and the phi value was calculated for each patient. The performance of these parameters in predicting the prostatic biopsy results was assessed.

Results

Two hundred and thirty consecutive patients, with 21 (9.13 %) diagnosed with PCa, were recruited for this study. Statistically significant differences between PCa patients and non-PCa patients were found for total PSA, PSA density, [-2]proPSA (p2PSA), free-to-total PSA ratio (%fPSA), p2PSA-to-free PSA ratio (%p2PSA), and phi. The areas under the curve of the receiver operating characteristic curve for total PSA, PSA density, %fPSA, %p2PSA, and phi were 0.547, 0.634, 0.654, 0.768, and 0.781, respectively. The phi was the best predictor of the prostatic biopsies results. At a sensitivity of 90 %, the use of the phi could have avoided unnecessary biopsies in 104 (45.2 %) patients.

Conclusions

Use of the phi could improve the accuracy of PCa detection in patients with an elevated PSA level and thus avoid unnecessary prostatic biopsies.

Keywords

Prostate cancer Biomarkers Screening Prostate-specific antigen PSA density PSA isoform 

Copyright information

© Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  • C. F. Ng
    • 1
  • Peter K. F. Chiu
    • 1
  • N. Y. Lam
    • 1
  • H. C. Lam
    • 1
  • Kim W. M. Lee
    • 1
  • Simon S. M. Hou
    • 1
  1. 1.Division of Urology, Department of SurgeryThe Chinese University of Hong KongHong Kong SARChina

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