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Pretransplant peritoneal dialysis relative to hemodialysis improves long-term survival of kidney transplant patients: a single-center observational study

Abstract

Background

Kidney transplantation is the best option for the treatment of end-stage renal disease in terms of survival and quality of life. These results can be influenced by the pretransplant dialysis modality. The aim of this study was to evaluate whether the pretransplantation dialysis modality influences patient and allograft survival beyond 10 years and examine the potential risk factors associated with the outcomes.

Methods

We conducted an observational, retrospective, single-center clinical study that included 236 patients [118 undergoing peritoneal dialysis (PD) and 118 undergoing hemodialysis (HD)] who proceeded to transplantation during the period December 1990–2002. Donor and recipient data were collected from our hospital’s clinical registries. The follow-up period extended to the patient’s death, the loss of the allograft, or loss to follow-up. The end date of the study was set at March 2012.

Results

In the multivariate analysis, the long-term patient survival rate was higher for the PD group than for the HD group [HR = 2.62 (1.01–6.8); p = 0.04]; however, the allograft survival rate was not significantly different between the two groups [HR = 0.68 (0.41–1.10); p = 0.12].

Conclusion

Pretransplantation dialysis modality is associated with long-term patient survival, with outcomes favoring peritoneal dialysis over hemodialysis. However, the pretransplant dialysis modality does not influence long-term graft loss risk.

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Acknowledgments

The authors would like to thank Juliette Siegfried and her team at ServingMed.com for their editing of the manuscript. The authors would like to thank Astellas Pharma for their unrestricted grant for this study.

Conflict of interest

The authors declare that they have no conflicts of interest.

Author information

Correspondence to María O. López-Oliva.

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López-Oliva, M.O., Rivas, B., Pérez-Fernández, E. et al. Pretransplant peritoneal dialysis relative to hemodialysis improves long-term survival of kidney transplant patients: a single-center observational study. Int Urol Nephrol 46, 825–832 (2014). https://doi.org/10.1007/s11255-013-0521-0

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Keywords

  • Peritoneal dialysis
  • Hemodialysis
  • Kidney transplantation
  • Outcomes