International Urology and Nephrology

, Volume 46, Issue 1, pp 57–62 | Cite as

Evaluation of the serum cystatin C values in prediction of indications for hemodialysis in patients with chronic renal failure

  • Dede Sit
  • Taner Basturk
  • Süleyman Yildirim
  • Ferdi Karagoz
  • Nalan Bozkurt
  • Ayşegül Gunes
Nephrology - Original Paper
First Online:
Received:
Accepted:

Abstract

Background

Indications of dialysis treatment for patients with end-stage renal disease depend on various clinical and laboratory parameters. In this study, we aimed to determine whether standardized serum cystatin C (SCC) equation may be an applicability of marker for dialysis initiation and its relationship to other clearance values among patients with advanced chronic kidney disease.

Materials and methods

A total of 84 patients (45 males, 39 females) aged 19–89 were evaluated in this study. Hemodialysis was indicated according to clinical and laboratory findings, and estimated glomerular filtration rate (eGFR) was according to four different formulas [MDRD, EpiCKD, Cockcroft Gault formula (CGF) and SCC equation].

Results

eGFR values of patients in the study were 7.23 ± 3.26, 7.86 ± 3.78, 15.09 ± 10.88 and 11.31 ± 4.54 according to MDRD, EpiCKD, SCC equation and CGF, respectively. There was a positive correlation between MDRD, EpiCKD and CGF, and between EpiCKD and CGF (p < 0.01). Also, statistically significant correlation was found between SCC equation and CGF (p < 0.05).

Conclusion

SCC equation was not seemed to be an appropriate marker for starting dialysis in patients with advanced CKD.

Keywords

Cystatin C End-stage renal disease Hemodialysis 
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Notes

Conflict of interest

The authors declare no conflict of interest.

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Copyright information

© Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  • Dede Sit
    • 1
  • Taner Basturk
    • 1
  • Süleyman Yildirim
    • 1
  • Ferdi Karagoz
    • 1
  • Nalan Bozkurt
    • 1
  • Ayşegül Gunes
    • 2
  1. 1.Clinic of Internal Medicine/NephrologyBagcilar Training and Research HospitalBagcılar, IstanbulTurkey
  2. 2.Department of BiochemistryBagcilar Training and Research HospitalIstanbulTurkey

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