International Urology and Nephrology

, Volume 46, Issue 1, pp 129–140 | Cite as

Nutritional predictors of early mortality in incident hemodialysis patients

  • Lilia R. Lukowsky
  • Leeka Kheifets
  • Onyebuchi A. Arah
  • Allen R. Nissenson
  • Kamyar Kalantar-Zadeh
Nephrology - Original Paper

Abstract

Purpose

Low serum albumin concentration and low dietary protein intake are associated with protein-energy wasting (PEW) and higher mortality in maintenance hemodialysis patients. The role of these nutritional markers is less clear in clinical outcomes of the first several months of dialysis therapy, where mortality is exceptionally high.

Methods

In a cohort of 17,445 incident hemodialysis patients, we examined variation in serum albumin and the normalized protein catabolic rate (nPCR), a surrogate of dietary intake, and quarterly mortality in the first 2 years of dialysis therapy. Cox proportional hazard models were fitted to estimate the association between mortality and combined albumin/nPCR categories for eight quarters. We investigated the associations between mortality and baseline and subsequent serum albumin levels per cohort quarter as well as changes in albumin and nPCR over time.

Results

Patients were 64 ± 15 years old (mean ± SD) and included 45 % women, 24 % African Americans and 58 % diabetics. Correlations between quarterly serum albumin and nPCR varied from 0.18 to 0.25. Serum albumin <3.5 g/dL was consistently associated with high mortality as was nPCR <1 g/kg/day (except for qtr1). Low serum albumin and nPCR greater than 0.2 g/dLg/dL or g/kg/day, respectively, were associated with increased risk of death. Quarterly rise in nPCR (>+0.2 g/kg/day) showed reverse effect on mortality from the 2nd to the last quarter.

Conclusions

Low serum albumin and nPCR are associated with mortality. A rapid rise in nPCR by the end of the second year may indicate pre-existing PEW.

Keywords

Hemodialysis Mortality Albumin Protein catabolic rate 

Supplementary material

11255_2013_459_MOESM1_ESM.docx (533 kb)
Supplementary material 1 (DOCX 534 kb)

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Copyright information

© Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  • Lilia R. Lukowsky
    • 1
    • 2
  • Leeka Kheifets
    • 2
  • Onyebuchi A. Arah
    • 2
    • 3
  • Allen R. Nissenson
    • 4
    • 5
  • Kamyar Kalantar-Zadeh
    • 1
    • 2
    • 4
  1. 1.Division of Nephrology and Hypertension, Harold Simmons Center for Chronic Disease Research and EpidemiologyLos Angeles Biomedical Research Institute at Harbor-UCLA Medical CenterTorranceUSA
  2. 2.Department of EpidemiologyUCLA Fielding School of Public HealthLos AngelesUSA
  3. 3.Department of Public Health, Academic Medical CenterUniversity of AmsterdamAmsterdamThe Netherlands
  4. 4.David Geffen School of Medicine at UCLALos AngelesUSA
  5. 5.DaVita, IncEl SegundoUSA

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