International Urology and Nephrology

, Volume 46, Issue 1, pp 255–260

Use of a polysulfone hemodialysis membrane may prevent recurrent posterior reversible encephalopathy syndrome in a patient undergoing hemodialysis

  • Akira Mima
  • Takeshi Matsubara
  • Shuichiro Endo
  • Taichi Murakami
  • Yasuki Hashimoto
Nephrology - Case Report


A 71-year-old woman underwent hemodialysis (HD) treatment for chronic kidney disease. During HD, she developed headache, abnormalities in visual perception, and generalized convulsion. Brain magnetic resonance imaging (MRI) showed T2-hyperintensity lesions in the posterior lobe, and an electroencephalogram showed slow waves in all areas. Twenty days later, the T2-hyperintensity lesions had vanished. Furthermore, perfusion computed tomography (CT) and single-photon emission CT with N-isopropyl[123I]-p-iodoamphetamine (IMP-SPECT) showed no significant abnormalities. The patient was diagnosed with posterior reversible encephalopathy syndrome (PRES) because she displayed typical clinical symptoms and MRI findings. Although several antihypertensive and antiseizure medications were administered, the patient experienced recurrent PRES. Therefore, we used a polysulfone dialyzer to reduce the oxidative stress and inflammation while preserving vascular endothelial function. After use of a polysulfone dialyzer membrane, the patient had no PRES episodes during the clinical course. This is the first study to demonstrate that use of a polysulfone dialyzer membrane instead of a cellulose membrane may prevent recurrent PRES.


Posterior reversible encephalopathy syndrome Hemodialysis Polysulfone dialyzer membrane Endothelial dysfunction Oxidative stress Inflammation 


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Copyright information

© Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  • Akira Mima
    • 1
    • 2
  • Takeshi Matsubara
    • 2
    • 3
  • Shuichiro Endo
    • 2
    • 3
  • Taichi Murakami
    • 1
    • 2
  • Yasuki Hashimoto
    • 2
    • 4
  1. 1.Department of Nephrology, Graduate School of Medicine, Institute of Health BiosciencesUniversity of TokushimaTokushimaJapan
  2. 2.Shizuoka City HospitalShizuokaJapan
  3. 3.Department of NephrologyKyoto University Graduate School of MedicineKyotoJapan
  4. 4.Hashimoto Medical ClinicAichiJapan

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