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International Urology and Nephrology

, Volume 45, Issue 1, pp 107–111 | Cite as

Primary adenocarcinoma of the urinary bladder: a single site analysis of 21 cases

  • Hu Zhang
  • Haowen Jiang
  • Zhong Wu
  • Zujun Fang
  • Jie Fan
  • Qiang Ding
Urology - Original Paper

Abstract

Purpose

To investigate whether there is a difference between urachal and non-urachal adenocarcinomas in terms of patient survival and to determine the significant prognostic factors.

Methods

Thirty-four patients with histologically proven adenocarcinoma of the urinary bladder were treated at Huashan hospital between 1999 and 2010. 13 cases were excluded, including 12 patients with metastatic involvement from gastrointestinal or reproductive tracts and one without follow-up data after the initial consultation. Life tables, Kaplan–Meier, Cox regression analysis and log-rank test were used.

Results

The difference between patients with urachal adenocarcinoma and patients with non-urachal adenocarcinoma was not statistically significant using the Kaplan–Meier estimates (P = 0.0763). Clinical stage had a significant influence on survival (P = 0.0320, Fig. 2). Patients with surgical resection including partial and radical cystectomy did not have a better prognosis (P = 0.7992, Fig. 3). However, the difference is statistically significant between patients who received partial cystectomy and patients who received radical cystectomy (P = 0.0123, Fig. 4).

Conclusion

Survival of Patients with adenocarcinoma is correlated with clinical stage. Patients with urachal adenocarcinoma and non-urachal adenocarcinoma may have similar survival outcome. Tumor stage was a highly significant predictor of outcome (P = 0.0320). Surgical resection seems to be more important than chemotherapy in the cases of adenocarcinoma of the urinary bladder. We are in favor of radical cystectomy for all patients.

Keywords

Bladder cancer Survival Recurrence Urachus Adenocarcinoma 

Notes

Acknowledgment

National Key Clinical Specialty Project, funded by Ministry of Health (MOH), P.R. China.

Conflict of interest

The authors have declared that no conflict of interest exists.

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Copyright information

© Springer Science+Business Media Dordrecht 2012

Authors and Affiliations

  • Hu Zhang
    • 1
  • Haowen Jiang
    • 1
  • Zhong Wu
    • 1
  • Zujun Fang
    • 1
  • Jie Fan
    • 1
  • Qiang Ding
    • 1
  1. 1.Department of Urology, Huashan HospitalFudan UniversityShanghaiChina

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