International Urology and Nephrology

, Volume 45, Issue 1, pp 107–111 | Cite as

Primary adenocarcinoma of the urinary bladder: a single site analysis of 21 cases

  • Hu Zhang
  • Haowen Jiang
  • Zhong Wu
  • Zujun Fang
  • Jie Fan
  • Qiang Ding
Urology - Original Paper



To investigate whether there is a difference between urachal and non-urachal adenocarcinomas in terms of patient survival and to determine the significant prognostic factors.


Thirty-four patients with histologically proven adenocarcinoma of the urinary bladder were treated at Huashan hospital between 1999 and 2010. 13 cases were excluded, including 12 patients with metastatic involvement from gastrointestinal or reproductive tracts and one without follow-up data after the initial consultation. Life tables, Kaplan–Meier, Cox regression analysis and log-rank test were used.


The difference between patients with urachal adenocarcinoma and patients with non-urachal adenocarcinoma was not statistically significant using the Kaplan–Meier estimates (P = 0.0763). Clinical stage had a significant influence on survival (P = 0.0320, Fig. 2). Patients with surgical resection including partial and radical cystectomy did not have a better prognosis (P = 0.7992, Fig. 3). However, the difference is statistically significant between patients who received partial cystectomy and patients who received radical cystectomy (P = 0.0123, Fig. 4).


Survival of Patients with adenocarcinoma is correlated with clinical stage. Patients with urachal adenocarcinoma and non-urachal adenocarcinoma may have similar survival outcome. Tumor stage was a highly significant predictor of outcome (P = 0.0320). Surgical resection seems to be more important than chemotherapy in the cases of adenocarcinoma of the urinary bladder. We are in favor of radical cystectomy for all patients.


Bladder cancer Survival Recurrence Urachus Adenocarcinoma 



National Key Clinical Specialty Project, funded by Ministry of Health (MOH), P.R. China.

Conflict of interest

The authors have declared that no conflict of interest exists.


  1. 1.
    Nielsen K, Nielsen KK (1983) Adenocarcinoma in exstrophy of the bladder-the last case in Scandinavia? A case report and review of the literature. J Urol 130:1180–1182PubMedGoogle Scholar
  2. 2.
    Sauter G, Algaba F, Amin M et al (2004) Tumour of urinary system: non-invasive urothelial neoplasia. In: Eble JN, Sauter G, Epstein J, Sesterhenn I (eds) WHO classification of classification of tumour of urinary system and male genital organs. IARCC Press, LyonGoogle Scholar
  3. 3.
    Johnson DE, Hodge GB, Abdul-Karim FW, Ayala AG (1985) Urachal carcinoma. Urology 26:218–221PubMedCrossRefGoogle Scholar
  4. 4.
    Petersen RO (1992) Urologic pathology, 2nd edn. Lippineott, Philadelphia, pp 268–270Google Scholar
  5. 5.
    Ploeg M, Aben KK, Hulsbergen-van de Kaa CA et al (2010) Clinical epidemiology of nonurothelial bladder cancer: analysis of The Netherlands Cancer Registry. J Urol 183:915–920PubMedCrossRefGoogle Scholar
  6. 6.
    Ghoneim MA, Abdel-Latif M, el-Mekresh M et al (2008) Radical cystectomy for carcinoma of the bladder: 2,720 consecutive cases 5 years later. J Urol 180:121–127PubMedCrossRefGoogle Scholar
  7. 7.
    Mostofi FK, Thomson RV, Dean AL Jr (1955) Mucous adenocarcinoma of the urinary bladder. Cancer 4:741–758CrossRefGoogle Scholar
  8. 8.
    Wheeler JD, Hill WT (1954) Adenocarcinoma involving the urinary bladder. Cancer 7:119–135PubMedCrossRefGoogle Scholar
  9. 9.
    Wright JL, Porter MP, Li CI et al (2006) Differences in survival among patients with urachal and nonurachal adenocarcinomas of the bladder. Cancer 107:721–728PubMedCrossRefGoogle Scholar
  10. 10.
    Dandekar NP, Dalal AV, Tongaonkar HB et al (1997) Adenocarcinoma of bladder. Eur J Surg Oncol 23:157–160PubMedCrossRefGoogle Scholar
  11. 11.
    De Santis M, Bachner M (2007) New developments in first- and second-line chemotherapy for transitional cell, squamous cell and adenocarcinoma of the bladder. Curr Opin Urol 17:363–368Google Scholar
  12. 12.
    Rajput MZ, Kamat AM, Clavell-Hernandez J et al (2011) Perioperative outcomes of laparoscopic radical nephroureterectomy and regional lymphadenectomy in patients with upper urinary tract urothelial carcinoma after neoadjuvant chemotherapy. Urology 78(1):61–67 Epub 2011 Feb 26PubMedCrossRefGoogle Scholar
  13. 13.
    Kakizoe T, Matsumoto K, Andoh M, Nishio Y, Kishi K (1983) Adenocarcinoma of urachus: report of 7 cases and review of literature. Urology 21:360–366PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media Dordrecht 2012

Authors and Affiliations

  • Hu Zhang
    • 1
  • Haowen Jiang
    • 1
  • Zhong Wu
    • 1
  • Zujun Fang
    • 1
  • Jie Fan
    • 1
  • Qiang Ding
    • 1
  1. 1.Department of Urology, Huashan HospitalFudan UniversityShanghaiChina

Personalised recommendations