It is unclear whether any significant changes in the epidemiology of chronic kidney disease (CKD), possibly resulting from the exceedingly rapid economic development and the aggressive prevention and treatment of kidney diseases in the Chinese population, have occurred over the past two decades.
The medical records of 173 CKD patients from 1990–1991 and 956 patients from 2009–2010 were retrospectively analyzed.
In patients from 1990–1991, CKD occurred at an earlier age, with severely decreased kidney function. On average, these patients progressed to end-stage renal disease 4.5 years faster. Diabetes and hypertension have become the most common causes of CKD in elderly patients in 2009–2010 period, representing 39.5 % and 24.2 % of all CKD causes, respectively. In the 1990–1991 period, CKD was characterized by a high frequency of severe anemia in stage 4 and 5 patients. The mean arterial pressure in patients with CKD stage 4 and stage 5 decreased significantly in. Although the number of dyslipidemia patients in stage 4 and 5 was significantly higher in the 2009–2010 period, there were no substantial differences in the average levels of serum triglycerides and total cholesterol in the two cohorts. Hypoproteinemia also became less common than before. The occurrence of cardiovascular events was significantly reduced in stage 4 and stage 5 patients in 2009–2010.
Diabetes and hypertension have increased and become the leading causes of CKD in elderly Chinese patients. Improvement in the control of CKD complications has been significant, mainly regarding anemia, hypertension, dyslipidemia, and hypoproteinemia.
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El Nahas AM, Bello AK (2005) Chronic kidney disease: the global challenge. Lancet 365:331–340
Dialysis and Transplantation Registration Group CSoNCMA (2001) The report about the registration of dialysis and transplantation in China 1999. Chin J Nephrol 17:77–78
Wu YK, Lu CQ, Gao RQ (1982) Nation-wide hypertension screening in China during 1979–1980. Chin Med J 95:101108
Fourth National Health and Nutrition Examination Survey Working Group (2004) Results from the Fourth National Health and Nutrition Examination Survey of China. Acta Nutr Sin 26:417–420
Liu LS, Chen MQ, Zeng GY et al (2002) A forty-year study on hypertension. Acta Acad Med Sin 24:401–408
Kidney Disease Outcome Quality Initiative (2002) K/DOQI clinical practice guidelines for chronic kidney disease: evaluation classification stratification. Am J Kidney Dis 39(Suppl 2):S1–S246
Ma YC, Zuo L, Chen JH et al (2006) Modified glomerular filtration rate estimating equation for Chinese patients with chronic kidney disease. J Am Soc Nephrol 17:2937–2944
Go AS, Chertow GM, Fan DJ et al (2004) Chronic kidney disease and the risks of death, cardiovascular events and hospitalization. N Engl J Med 351:1296–1305
Wang Y, Zhang L, Li X et al (2009) Improvement of awareness, treatment and control of hypertension among chronic kidney disease patients in China from 1999 to 2005. Hypertens Res 32:444–449
PRC National Blood Pressure Survey Cooperative Group (1995) Hypertension prevalence, the status of people awareness, treatment, control in China: a national-wide survey in 1991. Chin J Hypertens 3(Suppl 1):S14–S18
Gu D, Reynolds K, Wu X et al (2002) Prevalence awareness, treatment, and control of hypertension in China. Hypertension 40:920–927
Pan XR, Yang WY, Li GW et al (1997) Prevalence of diabetes and its risk factor in China, 1994. Diabetes Care 20:1664–1669
Yang W, Lu J, Weng J et al (2010) Prevalence of diabetes among men and women in China. N Engl J Med 362:1090–1101
Ruggenenti P, Schieppati A, Remuzzi G (2001) Progression, remission, and regression of chronic renal diseases. Lancet 357:1601–1608
Bakris GL, Williams M, Dworkin L et al (2000) Preserving renal function in adults with hypertension and diabetes: a consensus approach. Am J Kidney Dis 36:646–661
Kidney Disease Outcome Quality Initiative (2004) Clinical practice guidelines on hypertension and anti-hypertensive agents in chronic kidney disease. Am J Kidney Dis 43(Suppl 2):1–290
Fried LF, Orchard TJ, Kasiske BL et al (2001) Effects of lipid reduction on the progression of renal disease: a meta-analysis. Kidney Int 59:260–269
Barsoum RS (2006) Chronic kidney disease in the developing world. N Engl J Med 354:997–999
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Cao, Y., Li, W., Yang, G. et al. Diabetes and hypertension have become leading causes of CKD in Chinese elderly patients: a comparison between 1990–1991 and 2009–2010. Int Urol Nephrol 44, 1269–1276 (2012). https://doi.org/10.1007/s11255-012-0194-0
- Chronic kidney disease
- End-stage renal disease