International Urology and Nephrology

, Volume 45, Issue 1, pp 173–179 | Cite as

Evaluation of renal biopsies in type 2 diabetic patients with kidney disease: a clinicopathological study of 216 cases

  • Li Zhuo
  • Wenwen Ren
  • Wenge LiEmail author
  • Guming Zou
  • Jianhua Lu
Nephrology – Original Paper



The outcome and the therapy of patients with diabetes mellitus (DM), diabetic nephropathy (DN), and non-diabetic renal disease (NDRD) are quite different, so the differential diagnosis is of considerable importance. To evaluate the usefulness of renal biopsy in type 2 diabetic patients, we examined the relationship between the clinical parameters and the histopathological findings in different age groups.


Renal biopsy specimens and clinical and laboratory data from 216 patients with type 2 DM were evaluated. According to their age, three groups were defined: 17–35 years (group I), 36–59 years (group II), and more than 60 years (group III).


The study showed that, beside the duration of diabetes, other clinical parameters were not significantly different between the three groups. Chronic nephritic syndrome was the most common clinical manifestation in group I (44.1 %) and in group II (34.0 %). Among patients in group III, we found a high prevalence of chronic renal failure (34.3 %) and nephrotic syndrome (28.6 %). Consistent with the clinical manifestations, IgA nephropathy was the most common pathologic finding in group I (29.4 %) and in group II (34.7 %), whereas the most frequent abnormalities in group III were membranous nephropathy (25.7 %) and tubulointerstitial lesions (14.3 %). Overall, among these patients, 14 cases were diagnosed with DN (6.5 %), 179 with NDRD (82.9 %), while 23 had concurrent DN and NDRD (10.7 %).


Our results indicated that the clinical manifestations and pathologic findings in type 2 diabetic patients in different age groups have different features. This study emphasized the usefulness of renal biopsy for determining the pattern of renal damage and thus for the overall management of type 2 diabetic patients.


Type II diabetes mellitus Diabetic nephropathy (DN) Non-diabetic renal disease (NDRD) Renal biopsy Renal histopathology Age 



This work was supported by the National Natural Science Foundation of China (81170675), the Science Foundation of Chinese-Japanese Friendship Hospital (2010-ZD-05) and Postdoctoral Science Foundation of China (20090450200).

Conflict of interest

We have had no involvements that might raise the question of bias in the work reported or in the conclusions, implications, or opinions stated. The results presented in this paper have not been published previously in whole or part.


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Copyright information

© Springer Science+Business Media, B.V. 2012

Authors and Affiliations

  • Li Zhuo
    • 1
  • Wenwen Ren
    • 1
  • Wenge Li
    • 1
    Email author
  • Guming Zou
    • 1
  • Jianhua Lu
    • 1
  1. 1.Department of NephrologyChinese-Japanese Friendship HospitalHepingli, BeijingPeople’s Republic of China

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