The association between thyroid hormones and arterial stiffness in peritoneal dialysis patients
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The association between thyroid hormones and arterial stiffness is unclear. In this study, we investigated, for the first time in a large cohort of euthyroid peritoneal dialysis patients, the relationship between thyroid hormone levels and arterial stiffness.
Fifty-seven patients were enrolled. Serum TSH, free T3 and free T4 levels were measured by chemiluminescence immunoassay method. Pulse wave analysis [augmentation index (AIx) and subendocardial viability ratio (SEVR)] were measured to assess arterial stiffness.
Mean age was 49 ± 12.3 years, and 56.1% were female. Mean TSH, fT3 and fT4 levels were 1.97 ± 0.99 mIU/ml, 2.80 ± 0.42 pg/ml and 1.22 ± 0.16 ng/dl, respectively. Mean AIx and SEVR were 22.3 ± 11.3 and 136 ± 21%, respectively. AIx was negatively correlated with residual urine volume (r = −0.372, P: 0.03) and fT3 levels (r = −0.382, P: 0.005). SEVR was correlated only with TSH level (r = −0.394, P: 0.003). In linear regression analysis adjusted for age, gender, history of diabetes and cardiovascular disease and residual diuresis, fT3 level (t = −3.949, P < 0.001) remained associated with AIx. Only TSH level (t = −2.409, P: 0.02) was related to SEVR.
Low serum fT3 level is associated with arterial stiffness, and high TSH level within the normal range is related to lower SEVR in euthyroid PD patients.
KeywordsArterial stiffness Subendocardial viability ratio Thyroid hormone Low fT3 Peritoneal dialysis
The authors would like to thank Dr. Adrian Covic for his peer review of the manuscript and the nurses at the PD Unit at Ege University for their help in collection of data.
Conflict of Interest
The authors declare no conflict of interest.
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