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Octreotide reduces hepatic, renal and breast cystic volume in autosomal-dominant polycystic kidney disease

Abstract

A 43-year-old woman with autosomal-dominant polycystic kidney disease (ADPKD) received octreotide for 12 months, and this was associated with a 6.3% reduction in liver volume, an 8% reduction in total kidney volume and stabilization of renal function. There was also a reduction of cyst size in fibrocystic disease of breast. These data suggest that the cyst fluid accumulation in different organs from patients with ADPKD is a dynamic process which can be reversed by octreotide. This is the first report of a case of simultaneous reduction in hepatic, renal and breast cystic volume with preservation of renal function in a patient with ADPKD receiving octreotide.

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Acknowledgments

This work has been supported in part by grants from the Instituto de Salud Carlos III from Ministerio de Ciencia e Innovación (EC08/00236) and Programa Intensificación Actividad Investigadora (Agencia Laín-Entralgo/CM) to R.P.

Conflict of interest statements

None.

Author information

Correspondence to Ramón Peces.

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Peces, R., Cuesta-López, E., Peces, C. et al. Octreotide reduces hepatic, renal and breast cystic volume in autosomal-dominant polycystic kidney disease. Int Urol Nephrol 43, 565–569 (2011). https://doi.org/10.1007/s11255-010-9748-1

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Keywords

  • ADPKD
  • cAMP
  • Fibrocystic disease of breast
  • Octreotide
  • Renal function
  • Volume change