Up-regulation of microRNA in bladder tumor tissue is not common
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MicroRNAs (miRNAs) have recently been shown to down-regulate gene expression by targeting mRNA translation and to play a critical role in tumorigenesis; how they regulate bladder tumor development, particularly in patients, is, however, poorly understood. The difference in miRNA expression in a bladder tumor compared with healthy tissue from the same patients was examined using microRNA arrays in seven patients. Here, we showed that up-regulation of miRNA was not commonly found in this limited number of patients, and four miRNAs (miR-26a, miR-29c, miR-30c, miR-30e-5p) were down-regulated as a common marker in patients with a 1–3 grade of disease. Our data suggest that instead of up-regulation of carcinogenic miRNAs, loss of regulation of these miRNA may be critical for bladder tumor development in patients.
KeywordsBladder cancer MicroRNA Gene expression
The authors would like to thank Dr Guangdi Chen (Department of Dermatology and Skin Science, University of British Columbia) for reading the manuscript and editing the graphs, and Mr Robert H. Bell (Bioinformatics Group, Prostate Centre, Vancouver General Hospital) for his assistance with the analysis of miRNA expression profiles. This study was supported by a grant from the Hangzhou Science–Technology Development Program (No. 20043259) (Hangzhou, Zhejiang, P.R. China) (G. Wang) and by start-up funding from the University of British Columbia (C. Du).
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