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Is male fertility associated with type 2 diabetes mellitus?

  • Abdulbari BenerEmail author
  • Abdulla A. Al-Ansari
  • Mahmoud Zirie
  • Abdulla O. A. A. Al-Hamaq
Urology - Original Paper

Abstract

Objective

The aim of this study was to determine the prevalence of infertility in Qatari men with Diabetes Mellitus (T2DM) and to examine the association between T2DM and infertility.

Design

This is a cross-sectional study.

Setting

The survey was conducted at Primary Health Care Centers during a period from January 2008 to June 2008.

Subjects

The selected subjects for the study were Qatari men aged 25–60 years who were married for more than 1 year. A total of 1,165 men were approached and only 857 men gave consent, giving a response rate of 73.6%.

Methods

Face-to-face interviews were based on a questionnaire that included variables on socio-demographic characteristics, type of infertility in men, life style habits, type of environmental exposures, and common diseases found among infertile men. All studied men were recruited using cluster random sampling at 13 randomly selected primary health care centers at the Hamad Medical Corporation.

Results

The prevalence of infertility in Qatari T2DM men was 35.1%. The prevalence of primary infertility (16%) and secondary infertility (19.1%) was significantly higher in diabetic men (P = 0.003) as compared to non-diabetic men. Also, secondary infertility was higher than primary infertility in our studied Qatari diabetic men. Half of the diabetic infertile men were overweight (50.6%) and 29.1% of them were obese. The smoking habit was more common in diabetic infertile men (45.6%) than in diabetic fertile men (33.6%). Multivariate logistic regression analysis confirmed that age (P < 0.001), smoking habits (ex-smokers, P = 0.003 and current smokers, P = 0.001) and obesity (P < 0.001) were the significant major contributors for infertility in diabetic men. Obesity was the leading contributor for the infertility. Other co-morbid factors associated with infertility in diabetic men were hypertension, erectile dysfunction, and varicocele.

Conclusion

The present study findings revealed that there is a strong association between male infertility and Diabetes Mellitus. In Qatari diabetic men, male infertility is high and a significant public health problem in Qatar. The study results confirmed a strong association between T2DM and infertility in Qatari men.

Keywords

Prevalence Male infertility Risk factors Diabetes Hypertension Erectile dysfunction Qatar 

Notes

Acknowledgments

This work was funded by Qatar Diabetic Association and Qatar Foundation. The project was supported and approved by Ethical Review Committee at Hamad Medical Corporation, Project ID (7085/2007), Doha, the State of Qatar.

References

  1. 1.
    World Health Organization (2002) Diabetes: the cost of diabetes. (Fact sheet no. 236)Google Scholar
  2. 2.
    Agbaje IM, Rogers DA, McVicar CM, McClure N, Atkinson AB, Mallidis C, Lewis SE (2007) Insulin dependant diabetes mellitus: implications for male reproductive function. Hum Reprod 22(7):1871–1877. doi: 10.1093/humrep/dem077 CrossRefPubMedGoogle Scholar
  3. 3.
    Glenn DR, McClure N, Lewis SE (2003) The hidden impact of diabetes on male sexual dysfunction and fertility. Hum Fertil (Camb) 6:174–179CrossRefGoogle Scholar
  4. 4.
    Sexton JW, Jarow JP (1997) Effect of diabetes mellitus upon male reproductive function. Urology 49:508–513. doi: 10.1016/S0090-4295(96)00573-0 CrossRefPubMedGoogle Scholar
  5. 5.
    Spano M, Bonde JP et al (2000) Sperm Chromalin damage impairs human fertility: the danish first pregnancy planner study team. Fertil Sterile 73:43–50. doi: 10.1016/S0015-0282(99)00462-8 CrossRefGoogle Scholar
  6. 6.
    Zini A, Bielecki R, Phang D et al (2001) Correlation between two markers of sperm DNA integrity, DNA denaturation and DNA fragmentation, in fertile and infertile men. Fertil Steril 75:674–677. doi: 10.1016/S0015-0282(00)01796-9 CrossRefPubMedGoogle Scholar
  7. 7.
    Dinnulovic D, Radonjic G (1990) Diabetes mellitus, male infertility. Arch Androl 25:277–293. doi: 10.3109/01485019008987617 CrossRefGoogle Scholar
  8. 8.
    Roth LK, Taylor MS (2001) Risks of smoking to reproductive health: assessment of women’s knowledge. Am J Obstet Gynecol 184:934–939. doi: 10.1067/mob.2001.112103 CrossRefPubMedGoogle Scholar
  9. 9.
    Albert KG, Zimmet PZ (1998) Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med 15:539–553. doi: 10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S CrossRefGoogle Scholar
  10. 10.
    Kim SH, Chunawala L, Linde R, Reaven GM (2006) Comparison of the 1997 and 2003 American Diabetes Association classification of impaired fasting glucose: impact on prevalence of impaired fasting glucose, coronary heart disease risk factors, and coronary heart disease in a community-based medical practice. J Am Coll Cardiol 48:293–297. doi: 10.1016/j.jacc.2006.03.043 CrossRefPubMedGoogle Scholar
  11. 11.
    WHO (1991) Infertility: a tabulation of available data on prevalence of primary and secondary infertility, Geneva: WHO programme on maternal and child health and family planning, Division of Family HealthGoogle Scholar
  12. 12.
    Shaban S, Seaman E, Lipschultz LI (1991) Treatment of abnormalities of ejaculation. In: Lipschultz LI, Howards SS (eds) Infertility in the male, vol 3. Mosby year book, St Louis, pp 423–438Google Scholar
  13. 13.
    Sigman M, Jarrow J (2002) Male infertility. In: Walsh PC, Retik AB, Vaugh ED Jr., Wein AJ (eds) Campbell’s urology (8th edn). Saunders, Philadelphia, pp 1475–1531Google Scholar
  14. 14.
    Zheng M, Li G, Fan W, Zhang X, Chen S, Wang J et al (1999) The etiology of impotence in 326 diabetic adults. Zhonghua Nei Ke Za Zhi 38:546–549PubMedGoogle Scholar
  15. 15.
    Geelhoed DN, Nayembil D, Asare K, Schagenvan LJH, Roosmalen J (2002) Infertility in rural Ghana. Int J Gynaecol Obstet 79:137–142CrossRefPubMedGoogle Scholar
  16. 16.
    Braun M, Wassmer G, Klotz T, Reifenrath B, Mathers M, Engelmann U (2000) Epidemiology of erectile dysfunction: results of the “Cologne Male survey”. Int J Impot Res 12:305–311. doi: 10.1038/sj.ijir.3900622 CrossRefPubMedGoogle Scholar
  17. 17.
    Johannes CB, Araujo AB, Feldman HA, Derby CA, Kleinman KP, Mckinlay JB (2000) Incidence of ED in men 40 to 69 years old: longitudinal results from the Massachusetts male aging study. J Urol 163:460–463. doi: 10.1016/S0022-5347(05)67900-1 CrossRefPubMedGoogle Scholar
  18. 18.
    Tambi MI, Glasser DB (2003) Epidemiology of ED in 4 countries: cross sectional study of the prevalence and correlates of ED. Urology 61:201–206. doi: 10.1016/S0090-4295(02)02102-7 CrossRefGoogle Scholar
  19. 19.
    Delfino M, Imbrogno N, Elia J, Capogreco F, Mazzilli F (2007) Prevalence of DM in male partners of infertile couples. Minerva Urol Nefrol 59:131–135PubMedGoogle Scholar
  20. 20.
    Dunsmuir WD, Holmes SA (1996) The aetiology and management of erectile, ejaculatory and fertility problems in men with DM. Diabet Med 13:700–708. doi: 10.1002/(SICI)1096-9136(199608)13:8<700::AID-DIA174>3.0.CO;2-8 CrossRefPubMedGoogle Scholar
  21. 21.
    Bener A, Al-Hamaq AOAA, Kamran S, Al-Ansari A (2008) Prevalence of erectile dysfunction in stroke male patients and associated co-morbidities and risk factors. Int Urol Nephrol 40(3):701–708. doi: 10.1007/s11255-008-9334-y CrossRefPubMedGoogle Scholar
  22. 22.
    Fedorcsak P, Dale PO, Storeng R, Ertzeid G, Bjercke S, Oldereid N, Omland AK et al (2004) Impact of overweight and underweight on assisted reproduction treatment. Hum Reprod 19:2523–2528. doi: 10.1093/humrep/deh485 CrossRefPubMedGoogle Scholar
  23. 23.
    Kunzle R, Mueller MD, Hanggi W, Birkhauser MH, Drescher H, Bersinger NA (2003) Semen quality of male smokers and non smokers in infertile couples. Fertil Steril 79:287–291. doi: 10.1016/S0015-0282(02)04664-2 CrossRefPubMedGoogle Scholar
  24. 24.

Copyright information

© Springer Science+Business Media, B.V. 2009

Authors and Affiliations

  • Abdulbari Bener
    • 1
    • 2
    Email author
  • Abdulla A. Al-Ansari
    • 3
  • Mahmoud Zirie
    • 4
  • Abdulla O. A. A. Al-Hamaq
    • 5
  1. 1.Department of Medical Statistics & EpidemiologyHamad General Hospital, Hamad Medical Corporation, Weill Cornell Medical CollegeDohaQatar
  2. 2.Department of Evidence for Population Health Unit, School of Epidemiology and Health SciencesUniversity of ManchesterManchesterUK
  3. 3.Department of UrologyHamad General Hospital, Hamad Medical CorporationDohaQatar
  4. 4.Department of EndocrinologyHamad General Hospital, Hamad Medical CorporationDohaQatar
  5. 5.Qatar Diabetic Associations and Qatar FoundationDohaQatar

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