International Urology and Nephrology

, Volume 41, Issue 3, pp 553–557 | Cite as

A distinctive translocation carcinoma of the kidney [“rosette-like forming,” t(6;11), HMB45-positive renal tumor]

  • Milan Hora
  • Ondřej Hes
  • Tomáš Ürge
  • Viktor Eret
  • Jiří Klečka
  • Michal Michal
Urology - Original Paper



Recently, a novel renal carcinoma with specific clinical and histological characteristics and translocation t(6;11)(p21.1;q12 or q13) has been identified. We have found 11 cases in the literature, and we are adding another 3 cases.

Materials and methods

Three cases were found in the Plzeň pathological register with approximately 15,000 cases of kidney tumors. There were two females and 1 male, aged 22, 24, and 39 years.


The sizes of the tumors were 40, 136, and 10 mm. Two tumors were found incidentally; the biggest one was self-palpated by a 24-year-old pregnant patient. Patients are without any signs of disease 42, 20, and 17 months after surgery.


This tumor is a distinctive and rare translocation carcinoma of the kidney [t(6;11), HMB45 positive]. All cases with known clinical data arose in younger people. The malignant potential is probably low.


Kidney neoplasm Translocation carcinoma Immunohistochemistry Translocation t(6;11) Nephrectomy Gravidity 


  1. 1.
    Argani P, Ladanyi M (2004) Renal carcinomas associated with Xp11.2 translocations/TFE3 gene fusions. In: Eble JN, Sauter G, Epstein JI, Sesterhenn IA (eds) Tumours of the urinary system and male genital organs, pathology and genetics. IARC Press, Lyon, France, pp 37–38Google Scholar
  2. 2.
    Franzini A, Picozzi STM, Politi PL, Barana L, Bianchi F, Alfami G, Gatti G, Fanciullacci F, Gariboldi M, Strada M, Leone BE (2007) A case of renal cancer with Tfe3 gene vision in an elderly man. Clinical, radiological and surgical findings. Urol Int 78:179–181. doi: 10.1159/000098080 PubMedCrossRefGoogle Scholar
  3. 3.
    Argani P, Hawkins A, Griffin CA, Goldstein JD, Haas M, Beckwith JB et al (2001) A distinctive pediatric renal neoplasm characterised by epitheolid morphology, basement membrane production, focal HMB45 immunoreactivity, and t(6;11)(p21.1;q12) chromosome translocation. Am J Pathol 158:2089–2095PubMedGoogle Scholar
  4. 4.
    van Asseldonk M, Schepens M, de Bruijn D, Janssen B, Merkx G, van Kessel G (2000) Construction of a 350-kb sequence-ready 11q13 cosmid contig encompassing the markers D11S4933 and D11S546: mapping of 11 genes and 3 tumor-associated translocation breakpoints. Genomics 66:25–42Google Scholar
  5. 5.
    Davis IJ, Hsi B-L, Arroyo JD, Vargas SO, Yeh A, Motyckova G et al (2003) Cloning of an Alpha-TFEB fusion in renal tumors harboring the t(6;11)(p21;q13) chromosome translocation. Proc Natl Acad Sci USA 100:6051–6056. doi: 10.1073/pnas.0931430100 PubMedCrossRefGoogle Scholar
  6. 6.
    Dijkhuizen T, van den Berg E, Störkel S, van Kessel AG, Janssen B, de Jong B (1996) Two cases of renal cell carcinoma, clear cell type, revealing a t(6;11)(p21;q13). Cancer Genet Cytogenet 91:141. doi: 10.1016/S0165-4608(97)82578-2 CrossRefGoogle Scholar
  7. 7.
    Kuiper RP, Schepens M, Thijssen J, van Asseldonk M, van den Berg E, Bridge J et al (2003) Upregulation of the transcription factor TFEB in t(6;11)p21;q13)—positive renal cell carcinomas due to promoter substitution. Hum Mol Genet 12:1661–1669. doi: 10.1093/hmg/ddg178 PubMedCrossRefGoogle Scholar
  8. 8.
    Martignoni G, Tardanico R, Pea M, Pecciarini L, Gobbo S, Brunelli M et al (2005) t6;11 renal cell tumor. A clinicopathological study for two cases in adults. Mod Pathol 18(Suppl 1):155AGoogle Scholar
  9. 9.
    Argani P, Olgac S, Tickoo SK, Goldfischer M, Moch H, Chan DY et al (2007) Xp11 translocation renal cell carcinoma in adults: expanded clinical, pathological and genetic spectrum. Am J Surg Pathol 31:1149–1160. doi: 10.1097/PAS.0b013e318031ffff PubMedCrossRefGoogle Scholar
  10. 10.
    Pecciarini L, Cangi MG, Lo Cunsolo C, Macri’ E, Dal Cin E, Martignoni G et al (2007) Characterization of t(6;11)(p21;q12) in a renal-cell carcinoma of an adult patient. Genes Chromosomes Cancer 46:419–26. doi: 10.1002/gcc.20422 PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, B.V. 2008

Authors and Affiliations

  • Milan Hora
    • 1
  • Ondřej Hes
    • 2
  • Tomáš Ürge
    • 1
  • Viktor Eret
    • 1
  • Jiří Klečka
    • 1
  • Michal Michal
    • 2
  1. 1.Department of UrologyCharles University HospitalPlzenCzech Republic
  2. 2.Department of PathologyCharles University HospitalPlzenCzech Republic

Personalised recommendations