International Urology and Nephrology

, Volume 41, Issue 3, pp 679–685 | Cite as

Kaposi’s sarcoma following living donor kidney transplantation: review of 7,939 recipients

  • Behzad Einollahi
  • Mahboob Lessan-Pezeshki
  • Mohammad Hossein Nourbala
  • Naser Simforoosh
  • Vahid Pourfarziani
  • Eghlim Nemati
  • Mohsen Nafar
  • Abbas Basiri
  • Fatemeh Pour-Reza-Gholi
  • Ahmad Firoozan
  • Mohammad Hassan Ghadiani
  • Khadijeh Makhdoomi
  • Ali Ghafari
  • Pedram Ahmadpour
  • Farshid Oliaei
  • Mohammad Reza Ardalan
  • Atieh Makhlogh
  • Hamid Reza Samimagham
  • Jalal Azmandian
Nephrology - original paper

Abstract

Introduction

Kaposi’s sarcoma (KS) is one of the most common tumors to occur in kidney recipients, especially in the Middle East countries. Limited data with adequate sample size exist about the development of KS in living kidney recipients.

Methods

Therefore, we made a plan for a multicenter study, accounting for up to 36% (n = 7,939) of all kidney transplantation in Iran, to determine the incidence of KS after kidney transplantation between 1984 and 2007.

Results

Fifty-five (0.69%) recipients who developed KS after kidney transplantation were retrospectively evaluated with a median follow-up of 24 (1–180) months. KS occurred more often in older age when compared to patients without KS (49 ± 12 vs. 38 ± 15 years, P = 0.000). KS was frequently found during the first 2 years after transplantation (72.7%). Skin involvement was universal. Furthermore, overall mortality rate was 18%, and it was higher in patients with visceral involvement compared to those with mucocutaneous lesions (P = 0.01). However, KS had no adverse affect on patient and graft survival rates compared to those without KS. Forty-four patients with limited mucocutaneous disease and four with visceral disease responded to withdrawal or reduction of immunosuppression with or without other treatment modalities. Renal function was preserved when immunosuppression was reduced instead of withdrawn in patients with and without visceral involvement (P = 0.001 and 0.008, respectively).

Conclusion

The high incidence of KS in this large population studied, as compared to that reported in other transplant patient groups, suggests that genetic predisposition may play a pathogenetic role.

Keywords

Kaposi’s sarcoma Kidney transplantation Tumor Iran 

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Copyright information

© Springer Science+Business Media, B.V. 2008

Authors and Affiliations

  • Behzad Einollahi
    • 1
  • Mahboob Lessan-Pezeshki
    • 2
  • Mohammad Hossein Nourbala
    • 1
  • Naser Simforoosh
    • 3
  • Vahid Pourfarziani
    • 1
  • Eghlim Nemati
    • 1
  • Mohsen Nafar
    • 3
  • Abbas Basiri
    • 3
  • Fatemeh Pour-Reza-Gholi
    • 3
  • Ahmad Firoozan
    • 3
  • Mohammad Hassan Ghadiani
    • 1
  • Khadijeh Makhdoomi
    • 4
  • Ali Ghafari
    • 4
  • Pedram Ahmadpour
    • 3
  • Farshid Oliaei
    • 5
  • Mohammad Reza Ardalan
    • 6
  • Atieh Makhlogh
    • 7
  • Hamid Reza Samimagham
    • 8
  • Jalal Azmandian
    • 9
  1. 1.Nephrology Research CenterBaqiyatallah University of Medical SciencesTehranIran
  2. 2.Nephrology DepartmentTehran University of Medical SciencesTehranIran
  3. 3.Kidney Transplant DepartmentShahid Beheshti University of Medical SciencesTehranIran
  4. 4.Nephrology DepartmentUrmia University of Medical SciencesUrmiaIran
  5. 5.Nephrology DepartmentBabol University of Medical SciencesBabolIran
  6. 6.Nephrology DepartmentTabriz University of Medical SciencesTabrizIran
  7. 7.Nephrology DepartmentSari University of Medical SciencesSariIran
  8. 8.Nephrology DepartmentHormozgan University of Medical SciencesHormozganIran
  9. 9.Nephrology DepartmentKerman University of Medical SciencesKermanIran

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