VEGF, COX-2, and PCNA expression in renal cell carcinoma subtypes and their prognostic value
- 176 Downloads
To evaluate the prognostic value of new markers such as VEGF (vascular endothelial growth factor), COX-2 (cyclooxygenase-2), and PCNA (proliferating cell nuclear antigen) and review their differences in expression by histological subtype in patients with renal cell carcinoma (RCC).
About 99 patients who underwent radical (n = 79) or partial nephrectomy (n = 20) were included in this study. Histopathological specimens from the subjects were retrospectively analyzed immunohistochemically for the presence of VEGF, COX-2, or PCNA.
Mean staining ratios for VEGF, COX-2, and PCNA were 16.5, 16.8, and 31%, respectively. Correlations were evaluated among these three prognostic factors. There was no correlation between PCNA and VEGF (P = .068), but there were significant correlations between COX-2 and both PCNA and VEGF (P = .005 and P = .000, respectively). A significant correlation was found between the expression of VEGF and both pathologic stage and vascular invasion (P = .018 and P = .025, respectively). In addition, patients with conventional RCC had significantly lower VEGF and COX-2 levels than those with papillary RCC (P < .012).
It is obvious that prognostic factors such as VEGF, COX-2, and PCNA may vary depending on histological subtype. The level of expression of these factors together with histological subtype may provide valuable predictive information about the outcome of treatment.
KeywordsCOX-2 PCNA Prognostic factors Renal cell carcinoma VEGF
This study is granted by Baskent University School of Medicine (KA03/80).
- 16.Waseem NH, Lane DP (1990) Monoclonal antibody analysis of the proliferating cell nuclear antigen (PCNA). Structural conversion and the detection of a nucleolar form. J Cell Sci 90:121–125Google Scholar
- 17.Sobin LH, Wittekind CH (1997) International Union Against Cancer (UICC). TNM classification of malignant tumours, 5th edn. Wiley–Liss, New YorkGoogle Scholar
- 33.Delahunt B, Bethwaite PB, Nacey JN et al (1993) Proliferating cell nuclear antigen (PCNA) expression as a prognostic indicator for renal cell carcinoma: Comparison with tumour grade, mitotic index, and silver-staining nucleolar organizer region numbers. J Pathol 170:471–477PubMedCrossRefGoogle Scholar