International Urology and Nephrology

, Volume 40, Issue 2, pp 311–316

Urinary bladder leiomyosarcoma in adults

  • Apostolos P. Labanaris
  • Vahudin Zugor
  • Bernd Meyer
  • Reinhold Nützel
  • Stephan Helmus
  • Panagiotis G. Labanaris
  • Reinhard Kühn
Original Article

DOI: 10.1007/s11255-007-9288-5

Cite this article as:
Labanaris, A.P., Zugor, V., Meyer, B. et al. Int Urol Nephrol (2008) 40: 311. doi:10.1007/s11255-007-9288-5

Abstract

Introduction

Non-urothelial neoplasms of the bladder account for fewer than 5% of all bladder tumors. Sarcoma constitutes the most usual mesenchymal malignancy of the bladder, with leiomyosarcomas being the most common type of sarcoma in adults.

Patients and methods

The records of seven patients presenting to two different institutions with bladder leiomyosarcomas between 2003 and 2007 and between 2000 and 2007, respectively, were examined. Cystoscopy, with transurethral resection of the bladder tumor was initially performed in all patients, with leiomyosarcoma being initially diagnosed on the basis of examination of the transurethral specimen.

Results

There were N = 5 men and N = 2 women with a median age of 64.8 years at presentation. All seven patients underwent a definitive surgical procedure. Complete resection with negative surgical margins was achieved in all seven patients (100%). MSKCC stage included 86% of patients with stage 3 (N = 6) and 14% with stage 2 (N = 1). A low-grade tumor was evident in one patient only, with the remaining 86% exhibiting a high-grade tumor.

Discussion

Leiomyosarcomas of the bladder have always been considered as a highly aggressive entity and little is known about their origin, clinicopathologic presentation, and the survival factors associated with them. Contemporary studies suggest that these tumors may have a better prognosis than once believed. Leiomyosarcomas require aggressive surgical extirpation and, when surgical resection is possible, radical cystectomy with wide margins is the rule and should be performed. Strict adherence to standard surgical technique has resulted in low rates of positive surgical margins and low rates of local tumor recurrence.

Keywords

Bladder leiomyosarcoma Treatment Prognosis 

Copyright information

© Springer Science+Business Media B.V. 2007

Authors and Affiliations

  • Apostolos P. Labanaris
    • 1
  • Vahudin Zugor
    • 2
  • Bernd Meyer
    • 1
  • Reinhold Nützel
    • 1
  • Stephan Helmus
    • 1
  • Panagiotis G. Labanaris
    • 3
  • Reinhard Kühn
    • 1
  1. 1.Department of UrologyMartha Maria Medical CenterNurnbergGermany
  2. 2.Department of UrologyUniversity of Erlangen Medical CenterErlangenGermany
  3. 3.Department of UrologyInterbalkan Medical CenterThessalonikiGreece

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