International Urology and Nephrology

, Volume 40, Issue 1, pp 85–89

Diagnostic efficacy of free to total ratio of prostate-specific antigen and prostate-specific antigen velocity, singly and in combination, in detecting prostate cancer in patients with total serum prostate-specific antigen between 4 and 10 ng/ml

  • Shingo Yamamoto
  • Takuo Maruyama
  • Nobuyuki Kondoh
  • Michio Nojima
  • Hidekazu Takiuchi
  • Seiichi Hirota
  • Hiroki Shima
Original Article

DOI: 10.1007/s11255-007-9236-4

Cite this article as:
Yamamoto, S., Maruyama, T., Kondoh, N. et al. Int Urol Nephrol (2008) 40: 85. doi:10.1007/s11255-007-9236-4

Abstract

To assess the diagnostic efficacy of prostate-specific antigen (PSA)-related parameters, using a total of 226 patients with gray zone PSA who underwent prostate biopsy, various cutoff points of free to total ratio of PSA (f/t PSA) and PSA velocity (PSAV) were evaluated. Higher cutoff points of f/t PSA resulted in high sensitivity and negative predictive value (NPV): at f/t PSA <15%, sensitivity was 82.0% (41/50) and NPV 84.7% (50/59), and at f/t PSA <20%, 96.0% (48/50) and 92.3% (24/26). Lowering cutoff points also resulted in higher sensitivity and NPV: at PSAV ≥0.75 ng/ml per year, sensitivity was 71.4% (15/21) and NPV 82.4% (28/34), and at PSAV ≥0.40 ng/ml per year, 95.2% (20/21) and 95.2% (20/21). Further, among the patients with both of these parameters available, both sensitivity and NPV achieved 100% (10/10 and 7/7) when the indication for biopsy was determined as f/t PSA <15% or PSAV ≥0.40 ng/ml per year. Our results showed that unnecessary prostate biopsies could be more effectively avoided among patients with “gray zone PSA” by combination of f/t PSA and PSAV than single usage of these indexes.

Keywords

Free to total ratio of prostate-specific antigen (f/t PSA) Prostate-specific antigen (PSA) Prostate-specific antigen velocity (PSAV) 

Copyright information

© Springer Science+Business Media B.V. 2007

Authors and Affiliations

  • Shingo Yamamoto
    • 1
  • Takuo Maruyama
    • 1
  • Nobuyuki Kondoh
    • 1
  • Michio Nojima
    • 1
  • Hidekazu Takiuchi
    • 1
  • Seiichi Hirota
    • 2
  • Hiroki Shima
    • 1
  1. 1.Department of UrologyHyogo College of MedicineNishinomiyaJapan
  2. 2.Department of Surgical PathologyHyogo College of MedicineNishinomiyaJapan

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