International Urology and Nephrology

, Volume 39, Issue 3, pp 815–821 | Cite as

Intraurethral honey application for urethral injury: an experimental study

  • Ali Ayyıldız
  • K. Turgay Akgül
  • Özden Cebeci
  • Barış Nuhoğlu
  • Muzaffer Çaydere
  • Hüseyin Üstün
  • Cankon Germiyanoğlu
Original Paper



To evaluate the effect of honey applied intraurethrally after urethral injury on histopathological healing.

Materials and Methods

A total of Wistar male rats were used. The rats were divided into four groups: control (Group 1), sham (Group 2), 1 week honey applied group (Group 3) and 3 weeks honey applied group (Group 4). The urethral damage was caused with a 29 G needle. In sham group, only intraurethral saline solution was given, and 10% of honey was applied to rats in Groups 3 and 4 intraurethrally. After killing, penile tissues were investigated under a light microscopy.


The irregularities of urethral epithelium and connective tissue were observed in Group 1. Also narrowing of lumen was present in control group rats except one rat in which no inflammation and total healing were observed. Hyperemia–bleeding was found in whole rats. In Group 2, there were irregularities in urethral epithelium and connective tissue. Total healing was observed in one rat. In Group 3, while regularity in urethral epithelium was present in six rats, inflammation and fibrosis was absent in rats. In Group 4, inflammation and fibrous tissue accumulation were not observed in rats.


Intraurethral honey, applied after urethral injury, prevents inflammation, accelerates urethral healing and provides perfect healing.


Honey Injury Intraurethral Urethra Urethral stricture Wound healing 


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Copyright information

© Springer Science+Business Media, Inc. 2006

Authors and Affiliations

  • Ali Ayyıldız
    • 1
  • K. Turgay Akgül
    • 1
  • Özden Cebeci
    • 1
  • Barış Nuhoğlu
    • 1
  • Muzaffer Çaydere
    • 2
  • Hüseyin Üstün
    • 2
  • Cankon Germiyanoğlu
    • 1
  1. 1.Second Urology ClinicMinistry of Health Ankara Training and Research HospitalAnkaraTurkey
  2. 2.Department of PathologyMinistry of Health Ankara Training and Research HospitalAnkaraTurkey

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