International Urology and Nephrology

, Volume 39, Issue 3, pp 803–807

The effect of squamous and/or glandular differentiation on recurrence, progression and survival in urothelial carcinoma of bladder

  • Fikret Erdemir
  • Murat Tunc
  • Faruk Ozcan
  • Bekir S. Parlaktas
  • Nihat Uluocak
  • Isın Kılıcaslan
  • Ozgur Gokce
Original Paper



The effects of squamous and/or glandular differentiation in urothelial carcinoma of bladder on recurrence, progression and survival rate were evaluated in this study.

Patients and methods

Between 1998 and 2003, a total of 223 patients who had been treated with transurethral resection for bladder cancers were evaluated. The patients were divided into two groups as; Group I: tumor patients with squamous and/or glandular differentiation, Group II: patients without these findings.


Histologically 189 (84.7%) were conventional urothelial carcinoma and 34 (15.2%) were tumors with squamous and/or glandular differentiation. The mean age of the patients was 64.4 ± 12.7 (range 36–81) years. Survival rates within a period of 46.23 ± 14.8 (12–67) months were 76.47% for Group I and 89.94% for Group II (P = 0.027). The stage distribution as pTa, pT1, and ≥pT2 was 2 (5.9%), 18 (52.9%), and 14 (41.2%) in Group I and 101 (53.4%), 51 (27%) and 37 (19.6%) in group II, respectively (P = 0.001). There was a statistically significant tendency towards higher stage at presentation in Group I and the grade distribution was significantly higher in Group I than Group II (P < 0.001).


High recurrence rates and poor prognosis of these patients should be kept in mind in the follow-up period. In this respect, these patients should be followed up closely.


Bladder Carcinoma Squamous Glandular Prognosis 


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Copyright information

© Springer Science+Business Media, Inc. 2007

Authors and Affiliations

  • Fikret Erdemir
    • 1
    • 2
  • Murat Tunc
    • 3
  • Faruk Ozcan
    • 3
  • Bekir S. Parlaktas
    • 2
  • Nihat Uluocak
    • 2
  • Isın Kılıcaslan
    • 4
  • Ozgur Gokce
    • 3
  1. 1.TokatTurkey
  2. 2.Department of Urology, School of MedicineGaziosmanpasa UniversityTokatTurkey
  3. 3.Department of Urology, School of MedicineIstanbul UniversityIstanbulTurkey
  4. 4.Department of Pathology, School of MedicineIstanbul UniversityIstanbulTurkey

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