International Urology and Nephrology

, Volume 37, Issue 4, pp 773–777 | Cite as

Terazosin in the Treatment of Premature Ejaculation: A Short-term Follow-up

  • M. Murad BaşarEmail author
  • Erdal Yılmaz
  • Mehmet Ferhat
  • Halil Başar
  • Ertan Batislam


Aim: The aim of the present study was to evaluate the efficacy of terazosine in patients with premature ejaculation and lower urinary tract symptoms (LUTS), after excluding other sexual disorders and chronic prostatitis. Methods: A total of 90 patients with premature ejaculation and LUTS were enrolled to the study after excluding sexual disorders, prostatitis and benign prostatic hyperplasia. The patients were divided into two groups. Sixty patients in group 1 were treated with terazosine 5 mg daily for a month. Patients were followed monthly and questioned for their ejaculation problem. The results were classified as cure, improvement and ineffective. If patients showed improvement and ineffectiveness, the treatment was continued with 10 mg daily for the following month. Group 2 was included 30 patients, and placebo was applied for a month. At the end of this period, in patients who did not show any improvement, terazosine 10 mg was started. Results: In the treatment group, at the 1st month follow-up, 21 patients (35%) were cured, 20 (33.3%) showed improvement. In 19 (31.7%) patients, the treatment was ineffective. In group 2, 9 (30%) patients showed improvement and the rest had no-changes after one-month follow up. There was statistically significant difference between two groups (Pearson χ2 test=0.000). Later, terazosine 10 mg was given to the patients in group 2 and to the patients who showed improvement or unsuccessful result with terazosine 5 mg. With terazosine 10 mg, 10 (14.5%) patients were cured, 29 (42.2%) patients were improved. Finally, terazosine treatment in patients with premature ejaculation was found to be effective in 60 patients (66.7%).Conclusion: Alpha blockers seem to be physiological medical agents in the treatment of premature ejaculation since ejaculation is under sympathetic control. Moreover, these agents are effective in lower urinary tract and they should be used in patients with premature ejaculation and lower urinary tract symptoms.


Alpha blockers Premature ejaculation Lower urinary tract symptoms Terazosine IIEF IPSS 


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  1. 1.
    Master, VA, Turek, PJ 2001Ejaculatory physiology and dysfunctionUrol Clin North Am28363377CrossRefPubMedGoogle Scholar
  2. 2.
    Masters, WH, Johnson, VE 1970Human Sexual InadequacyLittle Brown & CoBostonGoogle Scholar
  3. 3.
    Rowland, DL, Haensel, SM, Blom, JH, Slob, AK 1993Penile sensitivity in men with prematre ejaculation and erectile dysfunctionJ Sex Marital Ther19189197PubMedGoogle Scholar
  4. 4.
    Althof, SE 1995Pharmacological treatment of rapid ejaculationPsychiatr Clin North Am188594PubMedGoogle Scholar
  5. 5.
    Cavalini, G 1995Alpha−1 blockade pharmacotherapy in primitive psychogenic premature ejaculation resistant to psychotherapyEur Urol28126130Google Scholar
  6. 6.
    Hsieh, JT, Liu, SP, Hsieh, CH, Cheng, JT 1999An in vivo evaluation of the therapeutic potential of sympatholytic agents on premature ejaculationBJU Int84503506CrossRefPubMedGoogle Scholar
  7. 7.
    Semans, JH 1956Premature ejaculation: a new approachSouth Med J49533538Google Scholar
  8. 8.
    Berkovitch, M, Keresteci, A, Koren, G 1995Efficacy of prilocaine-lidocaine cream in he treatment of premature ejaculationJ Urol15413601361PubMedGoogle Scholar
  9. 9.
    Fein, RL 1990Intracavernous medication for treatment of premature ejaculationUrology35301303CrossRefPubMedGoogle Scholar
  10. 10.
    Kaplan, PM 1994The use of seratoninergic uptake inhibitors in the treatment of premature ejaculationJ Sex Marital Ther20321324PubMedGoogle Scholar
  11. 11.
    Shilon, M, Paz, GF, Hommonai, ZT 1984The use of phenoxybenzamine treatment in premature ejaculationFertil Steril42659661PubMedGoogle Scholar
  12. 12.
    Waldinger, MD 2002The neurobiological approach to premature ejaculationJ Urol16823592367PubMedGoogle Scholar
  13. 13.
    Beretta, G, Chelo, E, Fanciullacci, F, Zanollo, A 1986Effect of alpha-blocking agent (phenoxybenzamine) in the management of premature ejaculationActa Eur Fertil174345PubMedGoogle Scholar
  14. 14.
    Yonezawa, A, Ando, R, Watanabe, C,  et al. 2001α2-Adrenoceptor antagonists: effects o ejaculation, penile erection and pelvic thrusting behavior in dogsPharm Biochem Behav70141147Google Scholar
  15. 15.
    Rosen, RC 2004Lower urinary tract symptoms and sexual dysfunction: additional evidence f an associationBJU Int93689690CrossRefPubMedGoogle Scholar
  16. 16.
    Schou, J, Holm, NR, Meyhoff, HH 1996Sexual function in patients with symptomatic benign prostatic hyperplasiaScand J Urol Nephrol Suppl179119122PubMedGoogle Scholar
  17. 17.
    Emberton, M, Neal, DE, Black, N,  et al. 1996The effect of prostatectomy on symptom severity and quality of lifeBr J Urol77233247PubMedGoogle Scholar
  18. 18.
    Peters, TJ 2001Relationship between LUTS and sexual functionProstate Cancer Prostatic Dis4S2S6CrossRefPubMedGoogle Scholar
  19. 19.
    Tubaro, A, Polito, M, Giambroni, L,  et al. 2001Sexual function in patients with LUTS suggestive of BPHEur Urol Suppl401922Google Scholar
  20. 20.
    Hofner, K, Claes, H, Reijke, TM,  et al. 1999Tamsulosin 0.4 mg once daily: effect on sexual function in patients with lower urinary tract symptoms suggestive of benign prostatic obstructionEur Urol36335341PubMedGoogle Scholar
  21. 21.
    O’Leary, MP 2002 Quality of life and alpha-blocker therapy: an important consideration for both the patient and the physicianUrology Suppl59 711Google Scholar
  22. 22.
    Schulman, C 2001Impact of treatment of BPH on sexualityProstate Cancer Prostatic Dis4S12S16CrossRefPubMedGoogle Scholar
  23. 23.
    Debruyne, FM, der Poel, HG 1999Clinical experience in Europe with uroselective alpha 1-antagonistsEur Urol Suppl365458Google Scholar

Copyright information

© Springer 2005

Authors and Affiliations

  • M. Murad Başar
    • 1
    Email author
  • Erdal Yılmaz
    • 1
  • Mehmet Ferhat
    • 1
  • Halil Başar
    • 1
  • Ertan Batislam
    • 1
  1. 1.Department of Urology, Faculty of MedicineUniversity of KırıkkaleKırıkkaleTurkey

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