International Urology and Nephrology

, Volume 37, Issue 3, pp 655–663 | Cite as

Prevention of Nephropathy in Patients with type 2 Diabetes Mellitus



The rising incidence of type 2 diabetes mellitus and of its complications will make it the most important health care challenge in the first quarter of the 21st Century. Diabetic nephropathy left unchecked will overwhelm the renal resources. Simple methods (proper diet and exercise, prevention of obesity) are successful in preventing type 2 diabetes in the great majority of the persons at risk. In patients with established type 2 diabetes, nephropathy can be prevented or greatly delayed by strict metabolic control, strict control of blood pressure using angiotensin-converting enzyme inhibitors and angiotensin receptor blockers as the first line of drugs, tight control of serum lipids using statins as indicated, low protein diet, avoidance of smoking and other nephrotoxic influences, prevention of abnormalities in calcium/phosphorus metabolism, and prevention of renal anemia by the early use of erythropoietin. Current research offers the promise of definitive prevention of both type 2 diabetes and diabetic nephropathy.


Diabetic nephropathy prevention Glycemia Hypertension Lipid metabolism Nephrotoxins Type 2 diabetes 


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Copyright information

© Springer 2005

Authors and Affiliations

  1. 1.Sections of Nephrology and General Internal Medicine, Renal Section (111C), New Mexico Veterans Affairs Health Care System and Department of MedicineUniversity of New Mexico School of MedicineAlbuquerqueUSA

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