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Economic losses caused by the use of low-efficacy anthelmintic drugs in growing heifers

  • Felipe Lamberti PivotoEmail author
  • Alfredo Skrebsky Cezar
  • Fernanda Silveira Flores Vogel
  • Camila Balconi Marques
  • Marta Elena Machado Alves
  • Camila Coelho Becker
  • Marta Lizandra do Rego Leal
Regular Articles

Abstract

The aim of this study was to compare the economic revenue related to the use of low- or high-efficacy anthelmintic drugs within suppressive or strategic schemes of treatment in growing heifers. Heifers raised in a semi-intensive grazing system in southern Brazil were used. Levamisole and ivermectin were selected as the high- and the low-efficacy drugs, respectively, based on a previous efficacy test. Subsequently, these drugs were used within strategic (Strat; four times per year) or suppressive (Supp; once a month) treatment regimens in the heifers, and their liveweight and eggs per gram of feces counts were monthly evaluated during a 13-month period. The total costs of the treatments and their cost-benefit ratio in regard to liveweight gain were calculated. Final mean liveweight gains (kg) observed were 126.7 (Strat-Low), 133.6 (Supp-Low), 141.3 (Strat-High), 142.9 (Supp-High), and 125.8 (Control). Treatments with a high-efficacy drug resulted in monetary gains of US$ 19.56 (Strat-High) and US$ 14.98 (Supp-High), but Supp-Low and Strat-Low treatments caused economic losses. Total cost of the efficacy test (US$ 374.79) could be paid by the additional liveweight gain of 20 heifers from the Strat-High group. These results showed that it would be preferable not to treat the heifers against GIN if compared with treating them with a low-efficacy drug. In addition, we showed that the use of four treatments per year with a high-efficacy drug—selected by efficacy test—resulted in a profitable management to control GIN in growing heifers raised in a semi-intensive gazing system in southern Brazil.

Keywords

Cattle Economic Nematodes Parasite resistance Weight gain 

Notes

Acknowledgments

The authors are grateful for the support of equipment necessary for the accomplishment of parasitological techniques of Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Supplementary material

11250_2019_2144_MOESM1_ESM.docx (16 kb)
ESM 1 (DOCX 16 kb)

References

  1. Alonso-Díaz, M.A., Arnaud-Ochoa, R.A., Becerra-Nava, R., Torres-Acosta, J.F.J., Rodriguez-Vivas, R.I., Quiroz-Romero, R.H., 2015. Frequency of cattle farms with ivermectin resistant gastrointestinal nematodes in Veracruz, Mexico, Veterinary Parasitology, 212, 439--443CrossRefGoogle Scholar
  2. Becerra-Nava, R., Alonso-Díaz, M.A., Fernández-Salas, A., Quiroz, R.H., 2014. First report of cattle farms with gastrointestinal nematodes resistant to levamisole in Mexico, Veterinary Parasitology, 204, 285--290CrossRefGoogle Scholar
  3. Borges, F.A., Silva, H.C., Buzzulini, C., Soares, V.E., Santos, E., Oliveira, G.P., Costa, A.J., 2008. Endectocide activity of a new long-action formulation containing 2.25% ivermectin+1.25% abamectin in cattle, Veterinary Parasitology, 155, 299—307CrossRefGoogle Scholar
  4. Borges, F.A., Almeida, G.D., Heckler, R.P., Lemes, R.T., Onizuka, M.K.V., Borges, D.G.L., 2013. Anthelmintic resistance impact on tropical beef cattle productivity: effect on weight gain of weaned calves, Tropical Animal Health Production, 45, 723--727CrossRefGoogle Scholar
  5. Borges, F.A., Borges, D.G.L., Heckler, R.P., Neves, J.P.L., Lopes, F.G., Onizuka, M.K.V., 2015. Multispecies resistance of cattle gastrointestinal nematodes to long-acting avermectin formulations in Mato Grosso do Sul, Veterinary Parasitology, 212, 299--302CrossRefGoogle Scholar
  6. Candy, P.M., Waghorn, T.S., Miller, C.M., Ganesh, S., Leathwick, D.M., 2018. The effect on liveweight gain of using anthelmintics with incomplete efficacy against resistant Cooperia oncophora in cattle, Veterinary Parasitology, 251, 56--62.CrossRefGoogle Scholar
  7. Cezar, A.S., Vogel, F.S.F., Sangioni, L.A., Antonello, A.M., Camillo, G., Toscan, G., Araujo, L.O., 2010. Anthelmintic action of different formulations of macrocyclic lactones on resistant strains of nematodes of cattle, Pesquisa Veterinaria Brasileira, 30, 523--528CrossRefGoogle Scholar
  8. Cezar, A.S., Ribas, H.O., Pivoto, F.L., Sangioni, L.A., Vogel, F.S.F., 2011. Combination of drugs as an alternative to control multi-resistant gastrointestinal nematodes in sheep, Pesquisa Veterinaria Brasileira, 31, 151--157CrossRefGoogle Scholar
  9. Charlier, J., Höglund, J., von Samson-Himmelstjerna, G., Dorny, P., Vercruysse, J., 2009. Gastrointestinal nematode infections in adult dairy cattle: impact on production, diagnosis and control, Veterinary Parasitology, 164, 70--79CrossRefGoogle Scholar
  10. Coles, G.C., Bauer, C., Borgsteede, F.H.M., Geerts, S., Klei, T.R., Taylor, M.A., Waller, P.J., 1992. World Association for the Advancement of Veterinary Parasitology (W.A.A.V.P.) methods for the detection of anthelmintic resistance in nematodes of veterinary importance, Veterinary Parasitology, 44, 35--44CrossRefGoogle Scholar
  11. Coles, G.C., Jackson, F., Pomroy, W.E., Prichard, R.K., von Samson-Himmelstjerna, G., Silvestre, A., Taylor, M.A., Vercruysse, J., 2006. The detection of anthelmintic resistance in nematodes of veterinary importance, Veterinary Parasitology, 136, 167--185CrossRefGoogle Scholar
  12. Cotter, J.L., Van Burgel, A., Besier, R.B., 2015. Anthelmintic resistance in nematodes of beef cattle in south-west Western Australia, Veterinary Parasitology, 207, 276--284CrossRefGoogle Scholar
  13. Cristel, S., Fiel, C., Anziani, O., Descarga, C., Cetrá, B., Romero, J., Fernández, S., Entrocasso, C., Lloberasi, M., Medus, D., Steffan, P., 2017. Anthelmintic resistance in grazing beef cattle in central and northeastern areas of Argentina—an update, Veterinary Parasitology: Regional Studies and Reports, 9, 25--28Google Scholar
  14. Delgado, F.E.F., Lima, W.S., da Cunha, A.P., Bello, A.C.P.P., Domingues, L.N., Wanderley, R.P.B., Leite, P.V.B., Leite, R.C., 2009. Cattle helminthiasis: farmers perception in Minas Gerais, Brazil, Revista Brasileira de Parasitologia Veterinaria, 18, 29--33CrossRefGoogle Scholar
  15. Edmonds, M.D., Johnson, E.G., Edmonds, J.D., 2010. Anthelmintic resistance of Ostertagia ostertagi and Cooperia oncophora to macrocyclic lactones in cattle from the western United States, Veterinary Parasitology, 170, 224--229CrossRefGoogle Scholar
  16. Edmonds, M.D., Vatta, A.F., Marchiondo, A.A., Vanimisetti, H.B., Edmonds, J.D., 2018. Concurrent treatment with a macrocyclic lactone and benzimidazole provides season long performance advantages in grazing cattle harboring macrocyclic lactone resistant nematodes, Veterinary Parasitology, 252, 157--162CrossRefGoogle Scholar
  17. Fazzio, L.E., Yacachury, N., Galvan, W.R., Peruzzo, E., Sánchez, R.O., Gimeno, E.J., 2012. Impact of ivermectin-resistant gastrointestinal nematodes in feedlot cattle in Argentina, Pesquisa Veterinaria Brasileira, 32, 419--423CrossRefGoogle Scholar
  18. Fazzio, L.E., Sánchez, R.O., Streitenberger, N., Galvan, W.R., Giudici, C.J., Gimeno, E.J., 2014. The effect of anthelmintic resistance on the productivity in feedlot cattle, Veterinary Parasitology, 206, 240--245CrossRefGoogle Scholar
  19. Forbes, A.B., Huckle, C.A., Gibb, M.J., Rook, A.J., Nuthall, R., 2000. Evaluation of the effects of nematode parasitism on grazing behaviour, herbage intake and growth in young grazing cattle, Veterinary Parasitology, 90, 111--118CrossRefGoogle Scholar
  20. Geurden, T., Chartier, C., Fanke, J., di Regalbono, A.F., Traversa, D., von Samson-Himmelstjerna, G., Demeler, J., Vanimisetti, H.B., Bartram, D.J., Denwood, M.J., 2015. Anthelmintic resistance to ivermectin and moxidectin in gastrointestinal nematodes of cattle in Europe, International Journal for Parasitology: Drugs and Drug Resistance, 5, 163--171PubMedGoogle Scholar
  21. Grisi, L., Leite, R.C., Martins, J.R.S., Barros, A.T.M., Andreotti, R., Cançado, P.H.D., León, A.A.P., Pereira, J.B., Villela, H.S., 2014. Reassessment of the potential economic impact of cattle parasites in Brazil, Revista Brasileira de Parasitologia Veterinária, 23, 150--156CrossRefGoogle Scholar
  22. Hawkins, J.A., 1993. Economic benefits of parasite control in cattle, Veterinary Parasitology, 46, 159--173CrossRefGoogle Scholar
  23. Heckler, R.P., Borges, D.G.L., Vieira, M.C., Conde, M.H., Green, M., Amorim, M.L., Echeverria, J.T., Oliveira, T.L., Moro, E., Van-Onselen, V.J., Borges, F.A., 2016. New approach for the strategic control of gastrointestinal nematodes in grazed beef cattle during the growing phase in central Brazil, Veterinary Parasitology, 221, 123--129CrossRefGoogle Scholar
  24. Lopes, W.D.Z., dos Santos, T.R., Sakamoto, C.A.M., de Lima, R.C.A., Valarelli, R.L., Paiva, P., da Costa, A.J., 2013. Persistent efficacy of 3.5% doramectin compared to 3.15% ivermectin against gastrointestinal nematodes in experimentally-infected cattle in Brazil, Research in Veterinary Science, 94, 290--294CrossRefGoogle Scholar
  25. Martínez-Valladares, M., Geurden, T., Bartram, D.J., Martínez-Pérez, J.M., Robles-Pérez, D., Bohórquez, A., Florez, E., Meana, A., Rojo-Vázquez, F.A., 2015. Resistance of gastrointestinal nematodes to the most commonly used anthelmintics in sheep, cattle and horses in Spain, Veterinary Parasitology, 211, 228--233CrossRefGoogle Scholar
  26. Molento, M.B., Buzatti, A., Sprenger, L.K., 2016. Pasture larval count as a supporting method for parasite epidemiology, population dynamic and control in ruminants, Livestock Science, 192, 48--54CrossRefGoogle Scholar
  27. Morel, N., Signorini, M.L., Mangold, A.J., Guglielmone, A.A., Nava, S., 2017. Strategic control of Rhipicephalus (Boophilus) microplus infestation on beef cattle grazed in Panicum maximum grasses in a subtropical semi-arid region of Argentina, Preventive Veterinary Medicine, 144, 179--183CrossRefGoogle Scholar
  28. Morri, C.A., 2007. A review of genetic resistance to disease in Bos taurus cattle, The Veterinary Journal, 3, 481--491CrossRefGoogle Scholar
  29. Ramos, F., Portella, L.P., Rodrigues, F.S., Reginato, C.Z., Pötter, L., Cezar, A.S., Sangioni, L.A., Vogel, F.S.F., 2016. Anthelmintic resistance in gastrointestinal nematodes of beef cattle in the state of Rio Grande do Sul, Brazil, International Journal for Parasitology: Drugs and Drug Resistance, 6, 93--101PubMedGoogle Scholar
  30. Rodrigues, F. dS, Cezar, A.S., Menezes, F. Rd., Sangioni, L.A., Vogel, F.S.F., Botton, S.A., 2017. Efficacy and economic analysis of two treatment regimens using toltrazuril in lambs naturally infected with Eimeria spp. on pasture, Parasitology Research, 116, 2911--2919CrossRefGoogle Scholar
  31. SAS Institute, 2011. Statistical analysis system user’s guide: statistics, version 9.3. Cary, USAGoogle Scholar
  32. Soutello, R.G.V., Seno, M.C.Z., Amarante, A.F.T., 2007. Anthelmintic resistance in cattle nematodes in northwestern São Paulo State, Brazil, Veterinary Parasitology, 148, 360-364CrossRefGoogle Scholar
  33. Stromberg, B.E., Gasbarre, L.C., Waite, A., Bechtol, D.T., Brown, M.S., Robinson, N.A., Olson, E.J., Newcomb, H., 2012. Cooperia punctata: effect on cattle productivity?, Veterinary Parasitology, 183, 284--291CrossRefGoogle Scholar
  34. Suarez, V.H., Cristel, S.L., 2014. Risk factors for anthelmintic resistance development in cattle gastrointestinal nematodes in Argentina, Revista Brasileira de Parasitologia Veterinaria, 23, 129--135CrossRefGoogle Scholar
  35. van Wyk, J.A., Cabaret, J., Michael, L.M., 2004. Morphological identification of nematode larvae of small ruminants and cattle simplified, Veterinary Parasitology, 119, 277--306CrossRefGoogle Scholar
  36. Waghorn, T.S., Miller, C.M., Leathwick, D.M., 2016. Confirmation of ivermectin resistance in Ostertagia ostertagi in cattle in New Zealand, Veterinary Parasitology, 229, 139--143CrossRefGoogle Scholar

Copyright information

© Springer Nature B.V. 2019

Authors and Affiliations

  • Felipe Lamberti Pivoto
    • 1
    Email author
  • Alfredo Skrebsky Cezar
    • 2
  • Fernanda Silveira Flores Vogel
    • 3
  • Camila Balconi Marques
    • 3
  • Marta Elena Machado Alves
    • 3
  • Camila Coelho Becker
    • 4
  • Marta Lizandra do Rego Leal
    • 1
  1. 1.Departamento de Clínica de Grandes Animais (DCGA)Universidade Federal de Santa Maria (UFSM)Santa MariaBrazil
  2. 2.Universidade Regional do Noroeste do Estado do Rio Grande do Sul (UNIJUI)IjuiBrazil
  3. 3.Departamento de Medicina Veterinária Preventiva (DMVP), Centro de Ciências Rurais (CCR)UFSMSanta MariaBrazil
  4. 4.Departamento de AgrometeorologiaUFSMSanta MariaBrazil

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