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Variations in serum metabolites in response to season, cyclicity, and pregnancy in estrus-synchronized Damascus goats

  • M. K. SarıbayEmail author
  • Z. Naseer
  • G. Doğruer
  • B. Özsoy
  • C. T. Ateş
Short Communications

Abstract

The current study was carried out to determine the changes in serum electrolytes, liver enzymes, and hormones during breeding and non-breeding seasons in estrus-synchronized goats. Forty goats (n = 40) were synchronized by inserting the sponges intravaginally for 12 days; PMSG and PGF2α were injected on day of sponge removal. Blood samples were collected from the goats at the time of sponges insertion (day -12), estrus day (day 0), and at 15 day after sponge withdrawal (day 15). The blood samples were analyzed for glucose, cholesterol (CHO), aspartate aminotransferase (AST), alanine aminotransferase (ALT), thyroid stimulating hormone (TSH), triiodothyronine (T3), thyroxine (T4) and progesterone (P4), calcium (Ca), phosphate (PO4), magnesium (Mg), sodium (Na), potassium (K), and chlorine (Cl) levels. Repeated measurements ANOVA of general linear model were used as statistical model. The results showed that seasons have an effect (p < 0.05) on glucose, Ca, Na, K, Cl, CHO, T3, and T4 levels. There was an effect (p < 0.05) of cyclicity only on P4 level. Whereas, nonpregnant, or goats carrying singlet and twin fetuses have shown variation (p < 0.05) in glucose, Ca, and P4 levels. Although, the correlations existed between different serum metabolites but strong correlations (p < 0.05) were observed either between Ca and Na or T3 and T4. In conclusion, the serum electrolytes and liver enzymes are correlated with hormones during the different seasons, pregnancy status, and fecundity. In recommendation, the results of the study could be as managemental tool to monitor the reproductive activity across seasons and to maintain pregnancy carrying twining in goat breeds.

Keywords

Serum metabolites Season Pregnancy Estrus synchronization Damascus goats 

Notes

Acknowledgments

The authors are grateful for Mr. Muhammad Shakeel for data analysis and interpretation. We are thankful Dr. Munibullah for critical review of article.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

References

  1. Abdollahi, E., Kohram, H and Shahir, M. H. 2013. Plasma concentrations of essential trace microminerals and thyroid hormones during single or twin pregnancies in fat-tailed ewes. Small Ruminant Research, 113: 360–364.CrossRefGoogle Scholar
  2. Al-Bulushi, S., Shawaf, T and Al-Hasani, A. 2017. Some hematological and biochemical parameters of different goat breeds in Sultanate of Oman “A preliminary study”, Veterinary World, 10(4): 461–466.CrossRefGoogle Scholar
  3. Al-Sobaiyl, K. A. 2010. Effect of breeding season and pregnancy status on serum progesterone, sodium, potassium, copper and iron of estrous synchronized Aradi goat does. Saudi Journal of Biological Sciences, 17: 259–263.CrossRefGoogle Scholar
  4. Alvarado-Espino, A. S., Menchaca, A, Meza-Herrera, C. A., Mellado, M., Arellano, F and Véliz, F. 2019. Use of injectable progesterone and hCG for fixed-time artificial insemination during the non-breeding season in goats. Theriogenology, 127: 21–25.CrossRefGoogle Scholar
  5. Anwar, M. M., Ramadan, T. A and Taha, T. A. 2012. Serum metabolites, milk yield, and physiological responses during the first week after kidding in Anglo-Nubian, Angora, Baladi, and Damascus goats under subtropical conditions. Journal of Animal Science, 90: 4795–4806.CrossRefGoogle Scholar
  6. Cappai, M. G., Liesegang, A., Dimauro, C., Mossa, F and Pinna, W. 2019. Circulating electrolytes in the bloodstream of transition Sarda goats make the difference in body fluid distribution between single vs. twin gestation. Research in Veterinary Science, 123: 84–90.CrossRefGoogle Scholar
  7. Cepeda-Palacios, R., Fuente-Gómez, M. G., Ramírez-Orduña, J. M., García-Álvarez, A., Llinas-Cervantes, X and Angulo, C. 2018. Effects of pregnancy and post-kidding stages on haematochemical parameters in cross-bred goats. Journal of Applied Animal Research, 46: 269–273.CrossRefGoogle Scholar
  8. Dupont, J., Scaramuzzi, R. J and Reverchon, M. 2014. The effect of nutrition and metabolic status on the development of follicles, oocytes and embryos in ruminants. Animal, 8: 1031–1044.CrossRefGoogle Scholar
  9. El-Tarabany, M. S., El-Tarabany, A. A and Atta, M. A. 2019. Effect of season on hormonal profile and some biochemical parameters at different stages of estrous cycles in Baladi goats. Biological Rhythm Research, 50: 245–254.CrossRefGoogle Scholar
  10. Fitz-Rodríguez, G., De Santiago-Miramontes, M. A., Scaramuzzi, R. J., Malpaux, B and Delgadillo, J. A. 2009. Nutritional supplementation improves ovulation and pregnancy rates in female goats managed under natural grazing conditions and exposed to the male effect. Animal Reproduction Science, 116: 85–94.CrossRefGoogle Scholar
  11. Fonseca, J. F., Souza-Fabjan, J. M. G., Oliveira, M. E. F., Cruz, R. C., Esteves, L. V., Matos de Paiva, M. P. S. L., Brandão, F.Z and Mancio, A.B. 2017. Evaluation of cervical mucus and reproductive efficiency of seasonally anovular dairy goats after short-term progestagen-based estrous induction protocols with different gonadotropins. Reproductive Biology, 17, 363–369.CrossRefGoogle Scholar
  12. Habibu, B., Kawu, M. U., Aluwong, T and Makun, H. J. 2017. Influence of seasonal changes on physiological variables, haematology and serum thyroid hormones profile in male Red Sokoto and Sahel goats. Journal of Applied Animal Research, 45: 508–516.CrossRefGoogle Scholar
  13. Haroon, S and Naveed, K. A. 2014. Effect of hormonal contraceptives on serum electrolytes and blood pressure. Journal of Post Medical Institute, 28(4): 409–413.Google Scholar
  14. Hassanein, M. R. R., Hussein, S. A and Hayat, H. E. 1999. Some bıochemıcal studıes durıng estrous cycle and after synchronızatıon ın Barkı ewes. Egyptian Journal of Biochemistry, 17: 281–299.Google Scholar
  15. Imasuen, J. A and Otoikhian, C. S. O. 2011. Assessment of serum biochemistry in West African Dwarf (WAD) does administered varying levels of medroxyl–progesterone acetate (MPA), an estrus synchronizing drug. African Journal of Biotechnology, 10: 5887–5892.Google Scholar
  16. Ishwar, A. K and Pandey, J.N. 1994. Blood metabolite changes in Black Bengal goats following estrus synchronization and superovulation. Small Ruminant Research, 13: 251–256.CrossRefGoogle Scholar
  17. Jin, Y. M., Zhang, X. Q., Badgery, W. B., Li, P and Wu, J. X. 2019. Effects of winter and spring housing on growth performance and blood metabolites of Pengbo semi-wool sheep in Tibet. Asian-Australasian Journal of Animal Science, DOI:  https://doi.org/10.5713/ajas.18.0966.CrossRefGoogle Scholar
  18. Kaminski, S. L., Redmer, D. A., Bass, C. S., Keisler, D. H., Carlson, L. S., Vonnahme, K. A., Dorsam, S. T and Grazul-Bilska, A.T. 2015. The effects of diet and arginine treatment on serum metabolites and selected hormones during the estrous cycle in sheep. Theriogenology, 83: 808–816.CrossRefGoogle Scholar
  19. Kandiel, M. M. M., El-Khaiat, H. M and Mahmoud, K. Gh. M. 2016. Changes in some hematobiochemical and hormonal profile in Barki sheep with various reproductive statuses. Small Ruminant Research, 136: 87–95.CrossRefGoogle Scholar
  20. Lanje, M. A., Bhutey, A. K., Kulkarni, S. R., Dhawle, U. P and Sande, A. S. 2010. Serum electrolytes during different phases of menstrual cycle. International Journal of Pharma Sciences and Research, 1: 435–437.Google Scholar
  21. Macías-Cruz, U., Vicente-Pérez, R., Correa-Calderón, A., Mellado, M., Meza-Herrera, C. A and Avendaño-Reyes, L. 2017. Undernutrition pre- and post-mating affects serum levels of glucose, cholesterol and progesterone, but not the reproductive efficiency of crossbred hair ewes synchronized for estrus. Livestock Science, 205: 64–69.CrossRefGoogle Scholar
  22. Mohammed, S., Razzaque, M. A., Omar, A., Albert, S. and Al-Gallaf, W. 2016. Biochemical and hematological profile of different breeds of goat maintained under intensive production system. African Journal of Biotechnology, 15: 1253–1257.CrossRefGoogle Scholar
  23. Moonmanee, T and Yammuen-art, S. 2015. Relationships among feed ıntake, blood metabolites, follicle size and progesterone concentration in ewes exhibiting or not exhibiting estrus after estrous synchronization in the tropics. Agriculture and Agricultural Science Procedia, 5: 151–158.CrossRefGoogle Scholar
  24. Nawito, M. F., Mahmoud, K. G. M., Kandiel, M. M. M., Ahmed, Y. F and Sosa, A.S.A. 2015. Effect of reproductive status on body condition score, progesterone concentration and trace minerals in sheep and goats reared in South Sinai, Egypt. African Journal of Biotechnology, 14: 3001–3005.CrossRefGoogle Scholar
  25. Njidda, A., Hassan, I and Olatunji, E. 2013. Haematological and biochemical parameters of goats of semi-arid environment fed on natural rangeland of Northern Nigeria. Journal of Agriculture and Veterinary Science, 3: 1–8.CrossRefGoogle Scholar
  26. Papachristoforou, C., Koumas, A and Photiou, C. 2000. Seasonal effects on puberty and reproductive characteristics of female Chios sheep and Damascus goats born in autumn or in February. Small Ruminant Research, 38: 9–15.CrossRefGoogle Scholar
  27. Pereira, E. S., Campos, A. C. N., Castelo-Branco, K. F., Bezerra, L. R., Gadelha, C. R. F., Silva, L. P., Pereira, M. W. F. and Oliveira, R. L. 2018. Impact of feed restriction, sexual class and age on the growth, blood metabolites and endocrine responses of hair lambs in a tropical climate. Small Ruminant Research, 158: 9–14.CrossRefGoogle Scholar
  28. Piccione, G., Messina, V., Vazzana, I., Dara, S., Giannetto, C and Assenza, A. 2012. Seasonal variations of some serum electrolyte concentrations in sheep and goats. Comparative Clinical Pathology, 21: 911–915.CrossRefGoogle Scholar
  29. Raoofi, A., Jafarian, M., Safib, S and Vatankhah, M. 2013. Fluctuations in energy-related metabolites during the peri-parturition period in Lori-Bakhtiari ewes. Small Ruminant Research, 109: 64–68.CrossRefGoogle Scholar
  30. Rathwa, S. D., Vasava, A. A., Pathan, M. M., Madhira, S. P., Patel, Y. G and Pande, A.M. 2017. Effect of season on physiological, biochemical, hormonal, and oxidative stress parameters of indigenous sheep. Veterinary World, 10: 650–654.CrossRefGoogle Scholar
  31. Romano, J. E., Alkar, A., Fuentes-Hernández, V. O and Amstalden, M. 2016. Continuous presence of male on estrus onset, estrus duration, and ovulation in estrus-synchronized Boer goats. Theriogenology, 85: 1323–1327.CrossRefGoogle Scholar
  32. Rumball, C. W. H., Bloomfield, F. H., Oliver, M. H and Harding, J.E. 2009. Different periods of periconceptional undernutrition have different effects on growth, metabolic and endocrine status in fetal sheep. Pediatric Research, 66, 605–613.CrossRefGoogle Scholar
  33. Samad A. R and Ford, E. J. H. 1981. The effects of progesterone on glucose and lactate metabolısm ın ovarıectomızed sheep. Quarterly Journal of Experimental Physiology banner, 66: 73–80CrossRefGoogle Scholar
  34. Samir, H., Karen, A., Ashmawy, T., Abo-Ahmed, M., El-Sayed, M and Watanabe, G. 2016. Monitoring of embryonic and fetal losses in different breeds of goats using real-time B-mode ultrasonography. Theriogenology, 85: 207–215.CrossRefGoogle Scholar
  35. Sejian, V., Bahadur, S and Naqvi, S. M. K. 2014. Effect of nutritional restriction on growth, adaptation physiology and estrous responses in Malpuras ewes. Animal Biology, 64: 189–205.CrossRefGoogle Scholar
  36. Senosy, W., Kassa, A. Y and Mohammed, A.A. 2017. Effects of feeding green microalgae on ovarian activity, reproductive hormones and metabolic parameters of Boer goats in arid subtropics. Theriogenology, 96: 16–22.CrossRefGoogle Scholar
  37. Sosa, C., Abecia, J. A., Carriquiry, M., Forcada, F., Martin, G. B., Palacín, I., Meikle, A. 2009. Early pregnancy alters the metabolic responses to restricted nutrition in sheep. Domestic Animal Endocrinology, 36: 13–23.CrossRefGoogle Scholar
  38. Swanson, T. J., Lekatz, L. A., Emon M. L. V., Perry, G. A., Schauer, C. S., Carlin, K. R. M., Hammer, C. J and Vonnahme, K.A. 2017. Supplementation of metabolizable protein during late gestation and fetal number impact ewe organ mass, maternal serum hormone and metabolite concentrations, and conceptus measurements. Domestic Animal Endocrinology, 58: 113–125.CrossRefGoogle Scholar
  39. Texeira, T. A., da Fonseca, J. F., de Souza-Fabjan, J. M., de Rezende, C. L., de Moura, F. D. A and Brandão, F.Z. 2016. Efficiency of different hormonal treatments for estrus synchronization in tropical Santa Inês sheep. Tropical Animal Health and Production, 48: 545–551.CrossRefGoogle Scholar
  40. Tirpan, M. B., Tekin, K., Cil, B., Alemdar, H., Inanc, M. E., Olgac, K. T., Stelletta, C., Daskin, A. 2018. The effects of different PMSG doses on estrus behavior and pregnancy rate in Angora goats. Animal, 27: 1–6.Google Scholar
  41. Yaqub, L. S., Kawu, M. U., Ayo, J. O., Ambali, S. F and Habibu, B. 2013. Effect of oestrous cycle on serum electrolytes and liver enzymes in Red Sokoto goats. African Journal of Biochemical Research, 7: 174–178.Google Scholar
  42. Zarazaga, L. A., Gatica, M. C., Gallego-Calvo, L., Celi, I and Guzmán, J.L. 2014. The timing of oestrus, the preovulatory LH surge and ovulation in Blanca Andaluza goats synchronised by intravaginal progestagen sponge treatment is modified by season but not by body condition score. Animal Reproduction Science, 146: 170–175.CrossRefGoogle Scholar

Copyright information

© Springer Nature B.V. 2019

Authors and Affiliations

  • M. K. Sarıbay
    • 1
    Email author
  • Z. Naseer
    • 2
  • G. Doğruer
    • 1
  • B. Özsoy
    • 3
  • C. T. Ateş
    • 4
  1. 1.Department of Obstetrics and Gynecology, Faculty of Veterinary MedicineHatay Mustafa Kemal UniversityHatayTurkey
  2. 2.Faculty of Veterinary and Animal SciencesPir Mehr Ali Shah Arid Agriculture UniversityRawalpindiPakistan
  3. 3.Department of Animal Nutrition and Nutritional Diseases, Faculty of Veterinary MedicineAydın Adnan Menderes UniversityAydınTurkey
  4. 4.Department of Animal Science, Faculty of Veterinary MedicineHatay Mustafa Kemal UniversityHatayTurkey

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