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Establishment of lung auscultation scoring method and responses of acute phase proteins and heat shock proteins in vaccinated and non-vaccinated goats

  • Faez Firdaus Abdullah Jesse
  • Eric Lim Teik Chung
  • Yusuf Abba
  • Kalai Vaani Muniandy
  • Ahmad Hafizin Ahmad Ramizi Tan
  • Dharshini Maslamany
  • Asinamai Athliamai Bitrus
  • Mohd Azmi Mohd Lila
  • Mohd Jefri Norsidin
Regular Articles

Abstract

Pneumonic pasteurellosis is an economically important infectious disease in the small ruminant industry which causes sudden death and loss for farmers. Nonetheless, this disease is still a common sight in sheep and goats in Malaysia, probably due to the unpopular usage of pasteurellosis vaccine or inappropriate vaccination practices. The aim of this study was designed to classify the severity of pneumonia via the establishment of auscultation scoring method and to quantify the acute phase proteins and heat shock proteins responses from vaccinated and non-vaccinated goats. Goat farms, consist of vaccinated and non-vaccinated farms, were selected in this study: where 15 clinically normal healthy goats and 9 pneumonic goats were selected from vaccinated farms whereas 15 clinically normal healthy goats and 31 pneumonic goats from non-vaccinated farms were selected for this study. Crackle lung sounds were not detected in both vaccinated and non-vaccinated normal goats. However, vaccinated pneumonic goats showed mild crackle lung sound while non-vaccinated pneumonic goats exhibited moderate crackle lung sound. There were significant increases (p < 0.05) in acute phase proteins and heat shock proteins concentrations for the non-vaccinated pneumonic goats group. In this study, conclusion can be made that the vaccinated goats exhibited very mild clinical responses of pneumonia and non-significant biomarker responses compared to the non-vaccinated goats. Thus, vaccination is an effective preventive measure to control pneumonic pasteurellosis and acute phase proteins and heat shock proteins can be considered as future biomarkers in screening and rapid diagnostic method for this particular disease.

Keywords

Pneumonic pasteurellosis Mannheimia haemolytica Vaccination Auscultation Acute phase proteins Heat shock proteins Goats 

Notes

Acknowledgments

The authors wish to express appreciation and thanks to the laboratory staff from Department of Veterinary Clinical Studies, Faculty of Veterinary Medicine, Universiti Putra Malaysia for their technical help and guidance.

Funding information

This research received financial support from the ITAFoS UPM.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer Nature B.V. 2018

Authors and Affiliations

  • Faez Firdaus Abdullah Jesse
    • 1
    • 2
  • Eric Lim Teik Chung
    • 3
  • Yusuf Abba
    • 1
    • 4
  • Kalai Vaani Muniandy
    • 1
  • Ahmad Hafizin Ahmad Ramizi Tan
    • 1
  • Dharshini Maslamany
    • 1
  • Asinamai Athliamai Bitrus
    • 5
  • Mohd Azmi Mohd Lila
    • 6
  • Mohd Jefri Norsidin
    • 1
  1. 1.Department of Veterinary Clinical Studies, Faculty of Veterinary MedicineUniversiti Putra MalaysiaSerdangMalaysia
  2. 2.Institute of Tropical Agriculture and Food SecurityUniversiti Putra MalaysiaSerdangMalaysia
  3. 3.Department of Animal Science, Faculty of AgricultureUniversiti Putra MalaysiaSerdangMalaysia
  4. 4.Department of Veterinary Pathology, Faculty of Veterinary MedicineUniversity of MaiduguriMaiduguriNigeria
  5. 5.Research Unit, Microbial Food Safety and Antimicrobial Resistance, Department of Veterinary Public Health, Faculty of Veterinary ScienceChulalongkorn UniversityPathumwanThailand
  6. 6.Department of Veterinary Pathology and Microbiology, Faculty of Veterinary MedicineUniversiti Putra MalaysiaSerdangMalaysia

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