Tropical Animal Health and Production

, Volume 49, Issue 8, pp 1689–1695 | Cite as

Evaluation of genetic and non-genetic factors on foot and mouth disease (FMD) virus vaccine-elicited immune response in Hardhenu (Bos taurus x Bos indicus) cattle

  • Manjeet
  • B. L. Pander
  • R. Sharma
  • S. S. Dhaka
  • Ankit MagotraEmail author
  • Kapil Dev
Regular Articles


Foot and mouth disease (FMD) is the most contagious disease of mammals and a major threat to animal husbandry sector. In India, vaccination with the inactivated trivalent (O, A and Asia1) vaccine is one proven way for protecting the livestock from FMD. However, many outbreaks have been reported in different parts of the country. Therefore, present study was aimed at elucidating the effects of genetic and non-genetic factors on FMD viral vaccine-elicited immune response in Hardhenu cattle. The effect of season of vaccination was not consistent. The effect of status of animal was significant for all the pre and post AB titres except for pre AB titre of serotype O and post AB titre of Asia1.The estimates of heritability for response to vaccination were low to high ranging from 0.11 to 0.45. The highest heritability estimate was obtained for serotype O and the lowest for Asia1. The heritability estimates for pre and post AB titres ranged from 0.15 to 0.33. All the pre and post AB titres and responses to vaccination had genetic correlations ranged from high negative to high positive among them. Results of this study highlight the variation in vaccine response which needs to be further exploited on large-scale animal data for better immunization and protection against highly contagious viral vesicular disease of cloven-hoofed animals.


Foot and mouth Hardhenu Serotype Titre 



We express our deep gratitude to the Vice Chancellor, Lala Lajpat Rai0020University of Veterinary and Animal Sciences, Hisar and the Head Regional Research Centre on FMD, located at LUVAS for providing necessary facilities.

Compliance with ethical standards

Conflict of interest

The authors declare that there are no conflicts of interest associated with this publication.


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Copyright information

© Springer Science+Business Media B.V. 2017

Authors and Affiliations

  • Manjeet
    • 1
  • B. L. Pander
    • 1
  • R. Sharma
    • 2
  • S. S. Dhaka
    • 1
  • Ankit Magotra
    • 1
    Email author
  • Kapil Dev
    • 1
  1. 1.Department of Animal Genetics and BreedingLala Lajpat Rai University of Veterinary and Animal SciencesHisarIndia
  2. 2.LUVASHisarIndia

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