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Tropical Animal Health and Production

, Volume 49, Issue 8, pp 1657–1662 | Cite as

Detection of QTL for greasy fleece weight in sheep using a 50 K single nucleotide polymorphism chip

  • Fatemeh Ebrahimi
  • Mohsen Gholizadeh
  • Ghodrat Rahimi-Mianji
  • Ayoub Farhadi
Regular Articles

Abstract

Genome-wide association studies (GWAS) have introduced an influential tool in the search for quantitative trait loci (QTL) influencing economically important traits in sheep. To identify QTL associated with greasy fleece weight, a GWAS with 50 K single nucleotide polymorphisms (SNPs) was performed in a Baluchi sheep population. Association with greasy fleece weights was tested using the software Plink. The results of our GWAS provided three novel SNP markers and candidate genes associated with greasy fleece weight. A total of three chromosome-wide significant associations were detected for SNP on chromosomes 17 and 20 affecting greasy fleece weight across the four shearing. One of the significant SNP markers was located within ovine known genes namely FAM101A. Further investigation of these identified regions in validation studies will facilitate the identification of strong candidate genes for wool production in sheep.

Keywords

Genome-wide association Sheep Wool production Quantitative trait loci 

Notes

Acknowledgements

This study was supported by Iran National Science Foundation (INSF). We also wish to thank Manager of Abbasabad sheep breeding station, Mashhad, Iran, for providing the data and samples.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer Science+Business Media B.V. 2017

Authors and Affiliations

  • Fatemeh Ebrahimi
    • 1
  • Mohsen Gholizadeh
    • 1
  • Ghodrat Rahimi-Mianji
    • 1
  • Ayoub Farhadi
    • 1
  1. 1.Department of Animal Science, Faculty of Animal and Aquatic ScienceSari Agricultural Sciences and Natural Resources UniversitySariIran

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