Twelve screened cases of bovine respiratory disease (BRD) in calves were enrolled. Six of the calves were treated intramuscularly with sodium ceftiofur (1 mg/kg), and six were treated with nebulised sodium ceftiofur (1 mg/kg). Comparative evaluation of the two therapeutic modalities was based on repetitive analysis of hematological profile of calves on days 0, 5, and 10 post-therapy. The mortality rate in the group of calves treated with the nebulised sodium ceftiofur was significantly (p < 0.001) lower, and their clinical and hematological parameters returned to normal significantly (p < 0.001) faster than in calves treated intramuscularly. Nebulisation of sodium ceftiofur is the most effective treatment in calves with BRD under field conditions. Nasal lavage fluid analysis indicating a high rise of neutrophil count and macrophages may be used as an alternative method to detect pulmonary inflammation in BRD-affected calves.
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The authors are highly thankful to the Director, ICAR-Indian Veterinary Research Institute, for providing the necessary research facilities to carry out this work.
All procedures have been conducted in accordance with the guidelines set out by the Committee for the Purpose of Control and Supervision of Experiments on Animals (CPCSEA).
Conflict of interest
The authors declare that they have no conflict of interest.
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Joshi, V., Gupta, V.K., Dimri, U. et al. Assessment of nebulisation of sodium ceftiofur in the treatment of calves naturally infected with bovine respiratory disease. Trop Anim Health Prod 49, 497–501 (2017). https://doi.org/10.1007/s11250-016-1219-y
- Bovine respiratory disease
- Sodium ceftiofur