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Assessment of nebulisation of sodium ceftiofur in the treatment of calves naturally infected with bovine respiratory disease

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Twelve screened cases of bovine respiratory disease (BRD) in calves were enrolled. Six of the calves were treated intramuscularly with sodium ceftiofur (1 mg/kg), and six were treated with nebulised sodium ceftiofur (1 mg/kg). Comparative evaluation of the two therapeutic modalities was based on repetitive analysis of hematological profile of calves on days 0, 5, and 10 post-therapy. The mortality rate in the group of calves treated with the nebulised sodium ceftiofur was significantly (p < 0.001) lower, and their clinical and hematological parameters returned to normal significantly (p < 0.001) faster than in calves treated intramuscularly. Nebulisation of sodium ceftiofur is the most effective treatment in calves with BRD under field conditions. Nasal lavage fluid analysis indicating a high rise of neutrophil count and macrophages may be used as an alternative method to detect pulmonary inflammation in BRD-affected calves.

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The authors are highly thankful to the Director, ICAR-Indian Veterinary Research Institute, for providing the necessary research facilities to carry out this work.

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Correspondence to Vivek Joshi.

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All procedures have been conducted in accordance with the guidelines set out by the Committee for the Purpose of Control and Supervision of Experiments on Animals (CPCSEA).

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The authors declare that they have no conflict of interest.

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Joshi, V., Gupta, V.K., Dimri, U. et al. Assessment of nebulisation of sodium ceftiofur in the treatment of calves naturally infected with bovine respiratory disease. Trop Anim Health Prod 49, 497–501 (2017). https://doi.org/10.1007/s11250-016-1219-y

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  • Bovine respiratory disease
  • Calves
  • Nebulisation
  • Sodium ceftiofur