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Severe meningeal fibrinoid vasculitis associated with Theileria taurotragi infection in two short-horned Zebu cattle

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Abstract

The Authors describe a severe vasculitis with fibrinoid necrosis of the meningeal arteries observed in two brains of indigenous short-horn zebu (Bos indicus) cattle, with bovine cerebral theileriosis (BCT) caused by a tick-transmitted hemoprotozoan, Theileria taurotragi, from Northern Tanzania. In the Author’s opinion, the role of T. taurotragi infection in the angiocentric and angiodestructive detected features remains to be evaluated. A possible immunopathologic cancerous mechanism, secondary to the lymphoid deregulation, could be involved. This report suggests further studies to better characterize the lymphoid cell involvement in the pathogenesis of the meningeal vascular lesions by T. taurotragi.

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Acknowledgments

The authors would like to thank the Maasai herders in Endulen district, who kindly collaborated to “Ormilo” cases identification and Dr. Federico Frosini for collaborating in the sample collection.

They wish also to thank Prof. F. Jongejan, Faculty of Veterinary Medicine, University of Utrecht, for his support during the early stages of the research and L. Chiappino and A. Sereno, Department of Veterinary Sciences, University of Turin, for the technical assistance.

Research activities were partially funded by DFID - UK Department for International Development, the Valle d’Aosta Region-development cooperation office, through the Italian NGO, AVEC PVS, Aosta (Italy), and the University of Torino.

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Correspondence to Maria Teresa Capucchio.

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The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. All authors gave their informed consent prior to their inclusion in the study.

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Biasibetti, E., Sferra, C., Lynen, G. et al. Severe meningeal fibrinoid vasculitis associated with Theileria taurotragi infection in two short-horned Zebu cattle. Trop Anim Health Prod 48, 1297–1299 (2016). https://doi.org/10.1007/s11250-016-1072-z

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Keywords

  • East-African short-horned Zebu
  • Brain
  • Histopathology
  • Immunopathology Theileria