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Tropical Animal Health and Production

, Volume 47, Issue 1, pp 103–109 | Cite as

Alteration in clinico-biochemical profile and oxidative stress indices associated with hyperglycaemia with special reference to diabetes in cattle—a pilot study

  • Padinjare Melepat DeepaEmail author
  • Umesh Dimri
  • Ricky Jhambh
  • Mohd Iqbal Yatoo
  • Bhaskar Sharma
Regular Articles

Abstract

The present study aimed to assess hyperglycaemia with special reference to diabetes mellitus in cattle by clinico-biochemical estimation and evaluation of oxidative stress indices. A total of 256 cattle exhibiting weakness, poor body condition and reduced milk yield in lactating cattle were included in the study. These animals were screened with blood glucose level, urine glucose and ketone bodies. Out of these, 32 (12.5 %) cattle showed hyperglycaemia and glycosuria, of which 25 % exhibited ketonuria. Diabetes was confirmed in five cattle by estimation of fasting blood glucose, glycated haemoglobin, serum fructosamine, intravenous glucose tolerance test and insulin level. This reports first confirmation of diabetes in cattle in India. All these five animals revealed low level of serum insulin suggestive of insulin-dependent diabetes mellitus in cattle. The level of aspartate aminotransferase (AST) and gamma glutamyl transferase (GGT) was found to be increased in diabetic cattle. Oxidant/antioxidant balance was assessed in hyperglycaemic cattle and five age-matched Holstein Friesian (HF) cross-bred healthy control animals. Diabetic cattle revealed significantly higher (P ≤ 0.01) levels of erythrocytic lipid peroxides in comparison with other hyperglycaemic cattle and healthy controls whereas the level of superoxide dismutase (SOD) and catalase was found to be significantly lower in diabetes-affected animals in comparison to healthy controls. Reduced glutathione did not show a significant difference between hyperglycaemic and control groups. It is concluded from the present study that oxidative stress associated with diabetes in cattle is obvious compared with other hyperglycaemic cattle.

Keywords

Cattle Diabetes Insulin Oxidative stress 

Notes

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer Science+Business Media Dordrecht 2014

Authors and Affiliations

  • Padinjare Melepat Deepa
    • 1
    Email author
  • Umesh Dimri
    • 1
  • Ricky Jhambh
    • 1
  • Mohd Iqbal Yatoo
    • 1
  • Bhaskar Sharma
    • 1
  1. 1.Indian Veterinary Research InstituteBareillyIndia

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