Tropical Animal Health and Production

, Volume 45, Issue 1, pp 35–43 | Cite as

Effectiveness of vaccines and vaccination programs for the control of foot-and-mouth disease in Uganda, 2001–2010

  • Michael Muleme
  • Robert Barigye
  • Margaret L. Khaitsa
  • Eugene Berry
  • Anthony W. Wamono
  • Chrisostom Ayebazibwe
Reviews

Abstract

Foot-and-mouth disease (FMD) is a highly contagious disease of cloven-hoofed animals. In Uganda, FMD outbreaks are mainly controlled by ring vaccination and restriction of animal movements. Vaccination stimulates immunity and prevents animals from developing clinical signs which include lameness, inappetence, and decreased production. Ring vaccination and restriction of animal movements have, however, not successfully controlled FMD in Uganda and outbreaks reoccur annually. The objective of this study was to review the use of FMD virus (FMDV) vaccines and assess the effectiveness of vaccination programs for controlling FMD in Uganda (2001–2010), using retrospective data. FMD vaccine distribution patterns in Uganda (2001–2010) matched occurrence of outbreaks with districts reporting the highest number of outbreaks also receiving the largest quantity of vaccines. This was possibly due to “fire brigade” response of vaccinating animals after outbreaks have been reported. On average, only 10.3 % of cattle within districts that reported outbreaks during the study period were vaccinated. The average minimum time between onset of outbreaks and vaccination was 7.5 weeks, while the annual cost of FMDV vaccines used ranged from US $58,000 to 1,088,820. Between 2001 and 2010, serotyping of FMD virus was done in only 9/121 FMD outbreaks, and there is no evidence that vaccine matching or vaccine potency tests have been done in Uganda. The probability of FMDV vaccine and outbreak mismatch, the delayed response to outbreaks through vaccination, and the high costs associated with importation of FMDV vaccines could be reduced if virus serotyping and subtyping as well as vaccine matching were regularly done, and the results were considered for vaccine manufacture.

Keywords

FMD Serotypes Multivalent vaccines Vaccination 

References

  1. Alexandersen, S., Mowat, N., 2005. Foot-and-mouth disease: host range and pathogenesis, Current Topics in Microbiology and Immunology, 288, 9–42PubMedCrossRefGoogle Scholar
  2. Arztl, J., Juleff, N., Zhang, Z. and Rodriguez, L. L., 2011. The pathogenesis of Foot-and-mouth disease I: viral pathways in cattle, Transboundary and Emerging Diseases. 58, 291–304CrossRefGoogle Scholar
  3. Ayebazibwe, C., Mwiine, F. N., Tjørnehøj K., Balinda, S. N., Muwanika, V. B., Ademun, O. R., Belsham, G. J., Normann, J., Siegismund, H. R., Alexandersen, S., 2010 b. The role of African buffalos (Syncerus caffer) in the maintenance of foot-and-mouth disease in Uganda, BioMed Central Veterinary Research, 6, 54, doi:10.1186/1746-6148-6-54 Google Scholar
  4. Ayebazibwe, C., Tjørnehøj, K., Mwiine, F. N., Muwanika, V. B., Ademun, O. A. R., Siegismund, H. R., Alexandersen, S., 2010a. Patterns, risk factors and characteristics of reported and perceived foot-and-mouth disease (FMD) in Uganda, Tropical Animal Health and Production, 42(7), 1547–1559PubMedCrossRefGoogle Scholar
  5. Balinda, S. N., Tjørnehøj, K., Muwanika, V. B., Sangula1, A. K., Mwiine, F. N., Ayebazibwe, C., Masembe, C., Siegismund, H. R. and Alexandersen, S. (2009). Prevalence Estimates of Antibodies Towards Foot-and-Mouth Disease Virus in Small Ruminants in Uganda, Transboundary and Emerging Diseases, 56, 362–371 PubMedCrossRefGoogle Scholar
  6. Belsham, J. G., Jamal, S. M., Tjørnehøj, K., Bøtner, A., 2011. Rescue of Foot-and-Mouth Disease Viruses that are Pathogenic for Cattle from Preserved Viral RNA Samples. PLoS ONE, 6(1), e14621. doi:10.1371/journal.pone.0014621 PubMedCrossRefGoogle Scholar
  7. Chowell, G., Rivas, A. L., Hengartner, N. W., Hyman, J. M., and Castillo-Chavez, C., 2006. Critical response to post-outbreak vaccination against foot-and-mouth disease. In: B.A. Gomel, C. Castillo-Chavez, R.E. Mickens, P.D. Clemence (eds), Mathematical studies on human disease dynamics: Emerging paradigms and challenges, Utah, 2006, (American Mathematical Society; Contemporary Mathematics 410), 73–87Google Scholar
  8. Doel, T. R., 2003. FMD Vaccines, Virus Research, 91, 81–99PubMedCrossRefGoogle Scholar
  9. Ecuru, J. and Naluyima, H., 2010. Biotechnology developments in Uganda and associated challenges, African Crop Science Journal, 18 (4), 133–139Google Scholar
  10. Grade, T., Tabuti, R. S. J., Van Damme, P., 2009. Ethnoveterinary knowledge in pastoral Karamoja, Kampala Uganda, Ethnopharmacology, 122, 273–293CrossRefGoogle Scholar
  11. Keeling, M. J., Woolhouse, M. E. J., May, R. M., Davies G., Grenfellk, B. T., 2003. Modeling vaccination strategies against foot-and-mouth disease, Nature, 421, 136–141PubMedCrossRefGoogle Scholar
  12. León, E. A., 2011. Foot-and-mouth disease in pigs: current epidemiological situation and control methods, Transboundary and Emerging Diseases, 59 (Supplement s1), 36–49Google Scholar
  13. Mwiine, F. N., Ayebazibwe, C., Olaho-Mukani, W., Alexandersen S. and Tjørnehøj K., 2010a. Prevalence of Antibodies Against Foot-and-Mouth Disease Virus in Cattle in Kasese and Bushenyi Districts in Uganda, International Journal of Animal and Veterinary Advance, 2(3), 89–96Google Scholar
  14. Mwiine, F. N., Ayebazibwe, C., Olaho-Mukani, W., Alexandersen, S., Balinda, S. N., Masembe, C., Ademun Okurut, A. R., Christensen, L. S., Sørensen, K. J., Tjørnehøj, K., 2010b. Serotype Specificity of Antibodies against Foot-and-Mouth Disease Virus in Cattle in Selected Districts in Uganda, Transboundary and Emerging Diseases, 57(5), 365–374PubMedCrossRefGoogle Scholar
  15. Pattnaik, B., Suramaniam, S., Sanyal, A., Mohapatra, J. K., Dash, B. B., Ranjan, R. and Rout, M., 2012. Foot-and-mouth disease: Global status and future road map for control and prevention in India, Agriculture Research, 1(2), 132–147CrossRefGoogle Scholar
  16. Perry, A.D., 2007, Poverty impacts of foot-and-mouth disease and poverty reduction implications of its control, The Veterinary Record 160, 238–241PubMedCrossRefGoogle Scholar
  17. Turner, L. R., 2005. Livestock, liberalization and democracy; constraints and opportunities for rural livestock producers in a reforming Uganda, Food and Agricultural Organization, Pro-Poor livestock Resource Initiative, paper 29Google Scholar
  18. UBOS/MAAIF, 2009. The national livestock census: A summary report of the national livestock census, 2008, Ministry of Agriculture Animal Industries and Fisheries and Uganda Bureau of Statistics, 41Google Scholar
  19. Uganda Industrial Research Institute (UIRI), 2011. Brentec Vaccines Limited. Available at: http://www.uiri.org/index.php?option=com_content&view=article&id=127&Itemid=196. Last accessed on 6/10/2012
  20. Windsor, P. A., Freeman, P. G., Abila, R., Benigno, C., Verin, B., Nim, V., and Cameron, A., 2011. Foot-and-mouth disease control and eradication in Bicol surveillance buffer zone of Philippines, Transboundary and Emerging Diseases, 58, 421–433PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media B.V. 2012

Authors and Affiliations

  • Michael Muleme
    • 1
    • 4
  • Robert Barigye
    • 1
  • Margaret L. Khaitsa
    • 1
  • Eugene Berry
    • 1
  • Anthony W. Wamono
    • 2
  • Chrisostom Ayebazibwe
    • 3
  1. 1.Veterinary and Microbiological Sciences DepartmentNorth Dakota State UniversityFargoUSA
  2. 2.Environment and Conservation Science ProgramNorth Dakota State UniversityFargoUSA
  3. 3.National Animal Disease Diagnostics and Epidemiology CenterMinistry of Agriculture, Animal Industry and FisheriesEntebbeUganda
  4. 4.College of Veterinary Medicine, Animal Resources and BiosecurityMakerere UniversityKampalaUganda

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