Tropical Animal Health and Production

, Volume 40, Issue 6, pp 463–467 | Cite as

Comparative efficacy of diminazene diaceturate and diminazene aceturate for the treatment of babesiosis in horses

  • Hamad Bin Rashid
  • Mamoona ChaudhryEmail author
  • Haroon Rashid
  • Khalid Pervez
  • Muhammad Arif Khan
  • Asim Khalid Mahmood
Original Paper


The present work was conducted to study the comparative efficacy of two anti-protozoan (babesicidal) drugs on the recovery and health of horses. A total of 80 horses, showing typical clinical symptoms of the disease, were selected for this study; the presence of babesiosis was confirmed through blood smear examination. These animals were divided into two groups i.e. A and B. Horses of Group A, were treated with diminazene diaceturate, while horses of Group B were treated with diminazene aceturate. Efficacy of the drugs was determined by the reversal of clinical signs and a negative blood smear examination. The efficacy of diminazene diaceturate was demonstrated to be 80% while diminazene aceturate was found to have 90% efficacy against babesiosis.


Babesiosis Babesia caballi Babesia equi Diminazene aceturate Diminazene diaceturate Equine Piroplasmosis 



The Authors thank Ansar Abbas and Prix Pharmaceutica, Pakistan for grant of samples of diminazene aceturate to be used in the study.

We are also thankful to Dr. Kim Picozzi, and Sally Uuastling, Centre for Tropical Veterinary Medicine, University of Edinburgh, UK, for editorial assistance.


  1. Ali, S., Sugimoto, C., and Onuma, M., 1996. Equine Piroplasmosis. Journal of Equine Science, 7, 67–77.CrossRefGoogle Scholar
  2. Anonymous., 2005. Economic Survey of Pakistan, Government of Pakistan, Islamabad, Pakistan, pp31.Google Scholar
  3. Avarzed, A., De-Waal, D. T., Tgarashi, T., Saifo, A., Oyamada, T., Toyoda, Y. and Suzuki, N., 1997. Prevalence of Equine Piroplasmosis in Central Mongolia. Onderstepoort Journal of Veterinary Research, 64, 141–145.PubMedGoogle Scholar
  4. Baturina, FM., 1975.The control of equine piroplasmosis. Problemy parazitologii. Materialy VIII nauchnoi konferentsii parazitologov UkSSR. Chast' 1. Izdatel'stvo "Naukova Dumka"., Kiev, USSR:. 59–60. (Abstract in English).Google Scholar
  5. Blaha, T., 1989. Development in animal and veterinary sciences, Applied Veterinary Epidemiology, (Elsevier), 194–196.Google Scholar
  6. Bruning, A., 1996. Equine piroplasmosis: an update on diagnosis, treatment and prevention. British Veterinary Journal, 152, 139–151.PubMedCrossRefGoogle Scholar
  7. Habela, M., Reina, D., Nieto, D., Verdugo, S. G., and Navarrcta, T., 1989. Epidemiology of Equine Babesiosis in Extremadura; Preliminary study. Medicina-Veterinaria, 6, 31–39.Google Scholar
  8. Hungerford, T. G., 1990. Diseases of Livestock, 9th Ed., (Mc-Graw Hill Book Co., New York, USA).Google Scholar
  9. Jennings, F. W., 1992. Chemotherapy of CNS-trypanosomiasis; the combined use of diminazene aceturate or pentamidine with DL-alpha-difluoromethyl ornithine (DFMO). Annals of Tropical Medicine and Parasitology, 13, 106–109.Google Scholar
  10. Mangat, I. S., 1993. Package of practices in Veterinary and Animal Husbandry for Livestock and Poultry. Punjab Agriculture University, Ludhiana, India, pp 126.Google Scholar
  11. Mohamed, A. A., and Yaqoub, I. A., 1990. Outbreaks of Babesiosis in domestic livestock in the Eastern region of Sudan. Tropical Animal Health and Production, 22, 123–125.PubMedCrossRefGoogle Scholar
  12. Oryan, A., Aslani, M. R., Rezakhani, A., Maleki, A., and Shaddel, F. A., 1994. Babesia caballi and associated pathological lesions in a horse. Equine Practice, 16, 33–37.Google Scholar
  13. Radostits, O. M., Gay, C. C., Blood, D. C., and Hinchcliff, K. W., 2000. Veterinary Medicine-A Textbook of the Diseases of Cattle, Sheep, Pigs, Goats and Horses. 9th Ed., (W. B. Saunders Co. Ltd., London, UK).Google Scholar
  14. Ribeiro, M. F. B., Saito, J. F., and Pimental, P. V., 1995. Equine Babesiosis. Primary infection in foals in an Endemic area. Arquivo-Brasilerio-de-Medicina-Veterinaria-e-Zootecnia, 47, 641–647. (With Abstract in English).Google Scholar
  15. Smith, B. P., 2002. Large Animal Internal Medicine. 3rd Ed., (Mosby Inc., Missouri, USA).Google Scholar
  16. Soulsby, E. J. L., 1982. Helminths, Arthropods and Protozoa of Domestic Animals. 7th Ed., (Bailliere Tindall, London, UK).Google Scholar
  17. Steel, R. G. D., and Torrie, J. H., 1982. Principals and Procedures of Statistics. 2nd Ed, (McGraw Hill Book Co. Inc., New York, USA).Google Scholar
  18. Vial, H. J. and Gorenflot, A., 2006. Chemotherapy against babesiosis. Veterinary Parasitology, 138, 147–160.PubMedCrossRefGoogle Scholar
  19. Wall, D. T., 1992. Equine Piroplasmosis, a review, British Veterinary Journal, 148, 6–8.Google Scholar
  20. Zweygarth E., Just M.C., De Waal D.T., 1997. In vitro cultivation of babesia equi: detection of carrier animals and isolation of parasites, Onderstepoort Journal Veterinary Research, 64, 51–56.Google Scholar

Copyright information

© Springer Science+Business Media B.V. 2007

Authors and Affiliations

  • Hamad Bin Rashid
    • 1
  • Mamoona Chaudhry
    • 1
    • 3
    Email author
  • Haroon Rashid
    • 2
  • Khalid Pervez
    • 1
  • Muhammad Arif Khan
    • 1
  • Asim Khalid Mahmood
    • 1
  1. 1.Faculty of Veterinary ScienceUniversity of Veterinary and Animal SciencesLahorePakistan
  2. 2.University College of Veterinary and Animal Sciences, The Islamia University BahawalpurBahawalpurPakistan
  3. 3.Centre for Tropical Veterinary MedicineRoyal (Dick) School of Veterinary Studies, Easter BushEdinburghUK

Personalised recommendations