Transgenic Research

, Volume 15, Issue 1, pp 13–19 | Cite as

Transgenic Plants for Insect Pest Control: A Forward Looking Scientific Perspective

  • N. Ferry
  • M. G. Edwards
  • J. Gatehouse
  • T. Capell
  • P. Christou
  • A. M. R. Gatehouse
Perspective

Abstract

One of the first successes of plant biotechnology has been the creation and commercialisation of transgenic crops exhibiting resistance to major insect pests. First generation products encompassed plants with single insecticidal Bt genes with resistance against major pests of corn and cotton. Modelling studies predicted that usefulness of these resistant plants would be short-lived, as a result of the ability of insects to develop resistance against single insecticidal gene products. However, despite such dire predictions no such collapse has taken place and the acreage of transgenic insect resistance crops has been increasing at a steady rate over the 9 years since the deployment of the first transgenic insect resistant plant. However, in order to assure durability and sustainability of resistance, novel strategies have been contemplated and are being developed. This perspective addresses a number of potentially useful strategies to assure the longevity of second and third generation insect resistant plants.

Keywords

durable insect pest resistance sustainability transgenic crops 

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References

  1. Abdeen, A, Virgos, A, Olivella, E, Villanueva, J, Aviles, X, Gabarra, R, Prat, S 2005Multiple insect resistence in transgenic tomato plants over-expressing two families of plant proteinase inhibitorsPlant Mol Biol57189202PubMedCrossRefGoogle Scholar
  2. Arimura, G, Tashiro, K, Kuhara, S, Nishioka, T, Ozawa, R, Takabayashi, J 2000Gene responses in bean leaves induced by herbivory and by herbivore-induced volatilesBiochem Biophys Res Commun277305310PubMedCrossRefGoogle Scholar
  3. Bailey, BA, Strem, MD, Bae, H, Antunez Mayolo, G, Guiltinan, MJ 2005Gene Expression in leaves of Theobroma cacao in response to mechanical wounding, ethylene and/or methyl jasmonatePlant Sci16812471258CrossRefGoogle Scholar
  4. Baldwin, IT, Halitschke, R, Kessler, A, Schittko, U 2001Merging molecular and ecological approaches in plant–insect interactionsCurr Opin Plant Biol4351358PubMedCrossRefGoogle Scholar
  5. Bates, SL, Zhao, JZ, Roush, RT, Shelton, AM 2005Insect resistance management in GM crops: past, present and futureNat Biotechnol235762PubMedCrossRefGoogle Scholar
  6. Boulter, D, Edwards, GA, Gatehouse, AMR, Gatehouse, JA, Hilder, VA 1990Additive protective effects of different plant-derived insect resistance genes in transgenic tobacco plantsCrop Protect9351354CrossRefGoogle Scholar
  7. Burgess, EPJ, Malone, LA, Christeller, JT, Lester, MT, Murray, C, Philip, BA, Phung, MM, Tregidga, EL 2002Avidin expressed in transgenic tobacco leaves confers resistance to two noctuid pests, Helicoverpa armigera and Spodoptera lituraTransgenic Res11185198PubMedCrossRefGoogle Scholar
  8. Chattopadhyay, A, Bhatnagar, NB, Bhatnagar, R 2005Bacterial insecticidal toxinsCrit Rev Microbiol303354CrossRefGoogle Scholar
  9. Chen, WQ, Provart, NJ, Glazebrook, J, Katagiri, F, Chang, HS, Eulgem, T, Mauch, F, Luan, S, Zou, GZ, Whitham, SA 2002Expression profile matrix of Arabidopsis transcription factor genes suggests their putative functions in response to environmental stressesPlant Cell14559574PubMedCrossRefGoogle Scholar
  10. Christeller, JT, Burgess, EPJ, Mett, V, Gatehouse, HS, Markwick, NP, Murray, C, Malone, LA, Wright, MA, Philip, BA, Watt, D 2002The expression of a mammalian proteinase inhibitor, bovine spleen trypsin inhibitor in tobacco and its effects on Helicoverpa armigera larvaeTransgenic Res11161173PubMedCrossRefGoogle Scholar
  11. Leo, F, Bonade-Bottino, M, Ceci, LR, Gallerani, R, Jouanin, L 2001Effects of a mustard trypsin inhibitor expressed in different plants on three Lepidopteran pestsInsect Biochem Mol Biol31593602PubMedCrossRefGoogle Scholar
  12. Divol, F, Vilaine, F, Thibivilliers, S, Amselem, J, Palauqui, JC, Kusiak, C, Dinant, S 2005Systemic response to aphid infestation by Myzus persicae in the phloem of Apium graveolensPlant Mol Biol57517540PubMedCrossRefGoogle Scholar
  13. Dixon, RA 2005Engineering of plant natural product pathwaysCurr Opin Plant Biol8329336PubMedCrossRefGoogle Scholar
  14. Eizaguirre, M, Albajes, R, Lopez, C, Jordi, E, Lumbierres, B, Pons, X 2006Six years after the commercial introduction of Bt maize in Spain: field evaluation, impact and future prospectsTransgenic Res15112PubMedCrossRefGoogle Scholar
  15. Fitches, E, Audsley, N, Gatehouse, JA, Edwards, JP 2002Fusion proteins containing neuropeptides as novel insect contol agents: snowdrop lectin delivers fused allatostatin to insect haemolymph following oral ingestionInsect Biochem Mol Biol3216531661PubMedCrossRefGoogle Scholar
  16. Fitches, E, Edwards, MG, Mee, C, Grishin, E, Gatehouse, AMR, Edwards, JP, Gatehouse, JA 2004Fusion proteins containing insect-specific toxins as pest control agents: snowdrop lectin delivers fused insecticidal spider venom toxin to insect haemolymph following oral ingestionJ Insect Physiol506171PubMedCrossRefGoogle Scholar
  17. Guo, HN, Chen, XY, Zhang, HL, Fang, RX, Yuan, ZQ, Zhang, ZS, Tian, YC 2004Characterization and activity enhancement of the phloem-specific pumpkin PP2 gene promoterTransgenic Res13559566PubMedCrossRefGoogle Scholar
  18. Hammond-Kosack, KE, Parker, JE 2003Deciphering plant–pathogen communication: fresh perspectives for molecular resistance breedingCurr Opin Biotechnol14177193PubMedCrossRefGoogle Scholar
  19. Heise, A, Lippok, B, Kirsch, C, Hahlbrock, K 2002Two immediate-early pathogen-responsive members of the AtCMPG gene family in Arabidopsis thaliana and the W-box-containing elicitor-response element of AtCMPG1Proc Natl Acad Sci USA9990499054PubMedCrossRefGoogle Scholar
  20. Hermsmeier, D, Schittko, U, Baldwin, IT 2001Molecular interactions between the specialist herbivore Manduca sexta (Lepidoptera, Sphingidae) and its natural host Nicotiana attenuata. I. Large-scale changes in the accumulation of growth- and defence-related plant mRNAsPlant Physiol125683700PubMedCrossRefGoogle Scholar
  21. Hooker, TS, Millar, AA, Kunst, L 2002Significance of the expression of the CER6 condensing enzyme for cuticular wax production in ArabidopsisPlant Physiol12915681580PubMedCrossRefGoogle Scholar
  22. Hui, DQ, Iqbal, J, Lehmann, K, Gase, K, Saluz, HP, Baldwin, IT 2003Molecular interactions between the specialist herbivore Manduca sexta (Lepidoptera, Sphingidae) and its natural host Nicotiana attenuata: V. Microarray analysis and further characterization of large-scale changes in herbivore-induced mRNAsPlant Physiol13118771893PubMedCrossRefGoogle Scholar
  23. James, C 2004Global Status of Commercialised Transgenic Crops ISAAA Briefs No.32: PreviewISAAAIthaca, NYGoogle Scholar
  24. Johnson, ET, Dowd, PF 2004Differentially enhanced insect resistance, at a cost, in Arabidopsis thaliana constitutively expressing a transcription factor of defensive metabolitesJ Agric Food Chem5251355138PubMedCrossRefGoogle Scholar
  25. Karlova, R, Weemen-Hendriks, M, Naimov, S, Ceron, J, Dukiandjiev, S, Maagd, RA 2005Bacillus thuringiensis delta-endotoxin Cry1Ac domain III enhances activity against Heliothis virescens in some, but not all Cry1-Cry1Ac hybridsJ Invertebr Pathol88169172PubMedCrossRefGoogle Scholar
  26. Kirsch, C 2001A highly specific pathogen-responsive promoter element from the immediate-early activated CMPG1 gene in Petroselinum crispumPlant J26217227PubMedCrossRefGoogle Scholar
  27. Maiti, IB, Dey, N, Pattanaik, S, Dahlman, DL, Rana, RL, Webb, BA 2003Antibiosis-type insect resistance in transgenic plants expressing a teratocyte secretory protein (TSP14) gene from a hymenopteran endoparasite (Microplitis croceipes)Plant Biotechnol J1209219CrossRefGoogle Scholar
  28. Maqbool, SB, Riazuddin, S, Loc, NT, Gatehouse, AMR, Gatehouse, JA, Christou, P 2001Expression of multiple insecticidal genes confers broad resistance against a range of different rice pestsMol Breed78593CrossRefGoogle Scholar
  29. Mehlo, L, Gahakwa, D, Nghia, PT, Loc, NT, Capell, T, Gatehouse, JA, Gatehouse, AMR, Christou, P 2005An alternative strategy for sustainable pest resistance in genetically enhanced cropsProc Natl Acad Sci USA10278127816PubMedCrossRefGoogle Scholar
  30. Mewis, I, Appel, HM, Hom, A, Raina, R, Schultz, JC 2005Major signaling pathways modulate Arabidopsis glucosinolate accumulation and response to both phloem-feeding and chewing insectsPlant Physiol13811491162PubMedCrossRefGoogle Scholar
  31. Michelmore, RW 2003The impact zone: genomics and breeding for durable disease resistanceCurr Opin Plant Biol6397404PubMedCrossRefGoogle Scholar
  32. Moellenbeck, DJ, Peters, ML, Bing, JW, Rouse, JR, Higgins, LS, Sims, L, Nevshemal, T, Marshall, L, Ellis, RT, Bystrak, PG 2001Insecticidal proteins from Bacillus thuringiensis protect from corn rootwormsNat Biotechnol19668672PubMedCrossRefGoogle Scholar
  33. Moran, PJ, Thompson, GA 2001Molecular responses to aphid feeding in Arabidopsis in relation to plant defense pathwaysPlant Physiol12510741085PubMedCrossRefGoogle Scholar
  34. Nagadhara, D, Ramesh, S, Pasalu, IC, Rao, YK, Sarma, NP, Reddy, VD, Rao, KV 2004Transgenic rice plants expressing the snowdrop lectin gene (gna) exhibit high-level resistance to the whitebacked planthopper (Sogatella furcifera)Theor Appl Genet10913991405PubMedCrossRefGoogle Scholar
  35. Okumoto, S, Koch, W, Tegeder, M, Fischer, WN, Biehl, A, Leister, D, Stierhof, YD, Frommer, WB 2004Root phloem-specific expression of the plasma membrane amino acid proton co-transporter AAP3J Exp Bot5521552168PubMedCrossRefGoogle Scholar
  36. Ostlie, K 2001Crafting crop resistance to corn rootwormsNat Biotechnol19624625PubMedCrossRefGoogle Scholar
  37. Padidam, M 2003Chemically regulated gene expression in plantsCurr Opin Plant Biol6169177PubMedCrossRefGoogle Scholar
  38. Retnakaran, A, Krell, P, Feng, QL, Arif, B 2003Ecdysone agonists: Mechanism and importance in controlling insect pests of agriculture and forestryArch Insect Biochem Physiol54187199PubMedCrossRefGoogle Scholar
  39. Rao, KV, Rathore, KS, Hodges, TK, Fu, X, Stoger, E, Sudhakar, D, Williams, S, Christou, P, Bharathi, M, Bown, DP, Powell, KS, Spence, J, Gatehouse, AMR, Gatehouse, JA 1998Expression of snowdrop lectin (GNA) in transgenic rice plants confers resistance to rice brown planthopperPlant J15469477PubMedCrossRefGoogle Scholar
  40. Rojo, E, Solano, R, Sanchez-Serrano, JJ 2003Interactions between signaling compounds involved in plant defenceJ Plant Growth Regul228298CrossRefGoogle Scholar
  41. Rushton, PJ, Reinstadler, A, Lipka, V, Lippok, B, Somssich, IE 2002Synthetic plant promoters containing defined regulatory elements provide novel insights into pathogen- and wound-induced signallingPlant Cell14749762PubMedCrossRefGoogle Scholar
  42. Schenk, PM, Kazan, K, Wilson, I, Anderson, JP, Richmond, T, Somerville, SC, Manners, JM 2000Coordinated plant defence responses in Arabidopsis revealed by microarray analysisProc Natl Acad Sci USA971165511660PubMedCrossRefGoogle Scholar
  43. Segal, DJ, Stege, JT, Barbas, CF 2003Zinc fingers and a green thumb: manipulating gene expression in plantsCurr Opin Plant Biol6163168PubMedCrossRefGoogle Scholar
  44. Singh, PK, Kumar, M, Chaturvedi, CP, Yadav, D, Tuli, R 2004Development of a hybrid delta-endotoxin and its expression in tobacco and cotton for control of a polyphagous pest Spodoptera lituraTransgenic Res13397410PubMedCrossRefGoogle Scholar
  45. Stout, MJ, Fidantsef, AL, Duffey, SS, Bostock, RM 1999Signal interactions in pathogen and insect attack: systemic plant-mediated interactions between pathogens and herbivores of the tomato, Lycopersicon esculentumPhysiol Mol Plant Pathol54115130CrossRefGoogle Scholar
  46. Tomsett, B, Tregova, A, Garoosi, A, Caddick, M 2004Ethanol-inducible gene expression: first step towards a new green revolution?Trends Plant Sci9159161PubMedCrossRefGoogle Scholar
  47. Tortiglione, C, Fogliano, V, Ferracane, R, Fanti, P, Pennacchio, F, Monti, LM, Rao, R 2003An insect peptide engineered into the tomato prosystemin gene is released in transgenic tobacco plants and exerts biological activityPlant Mol Biol53891902PubMedCrossRefGoogle Scholar
  48. Zhang, F, Zhu, L, He, GC 2004Differential gene expression in response to brown planthopper feeding in riceJ Plant Physiol1615362PubMedCrossRefGoogle Scholar
  49. Zhao, J-Z, Cao, J, Li, Y, Collins, HL, Roush, R, Earle, ED, Shelton, AM 2003Transgenic plants expressing two Bacillus thuringiensis toxins delay insect resistance evolutionNat Biotechnol2114931497PubMedCrossRefGoogle Scholar
  50. Zhu-Salzman, K, Ahn, JE, Salzman, RA, Koiwa, H, Shade, RE, Balfe, S 2003Fusion of a soybean cysteine protease inhibitor and a legume lectin enhances anti-insect activity synergisticallyAgric Forest Entomol5317323CrossRefGoogle Scholar

Copyright information

© Springer 2006

Authors and Affiliations

  • N. Ferry
    • 1
  • M. G. Edwards
    • 1
  • J. Gatehouse
    • 2
  • T. Capell
    • 3
  • P. Christou
    • 3
  • A. M. R. Gatehouse
    • 1
  1. 1.School of BiologyUniversity of Newcastle-upon-TyneNewcastle-upon-TyneUK
  2. 2.School of Biological and Biomedical SciencesUniversity of DurhamDurhamUK
  3. 3.Departament de Produccio Vegetal I Ciencia ForestalUniversitat de Lleida, ICREALleidaSpain

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