Enantioselective Hydrogenation of Ethyl Benzoylformate, from Mechanism and Kinetics to Continuous Reactor Technology
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The enantioselective hydrogenation of ethyl benzoylformate over (−)-cinchonidine (CD)-modified Pt/Al2O3 catalyst in semi-batch and continuous fixed bed reactors was studied as a function of the modifier concentration and reaction temperature. The kinetic results from the semibatch reactor showed a higher enantioselectivity and lower initial rate as the amount of modifier was increased. The results from the fixed bed reactor demonstrates that continuous enantioselective hydrogenation is possible and that continuous feeding of (−)-CD is needed to maintain a high steady-state enantioselectivity.
KeywordsEnantioselective hydrogenation Pt catalyst (−)-Cinchonidine Continuous operation
This work is part of the activities at the Åbo Akademi University Process Chemistry Centre (ÅA-PCC). Financial support from the Academy of Finland is gratefully acknowledged.
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