Calcium Chloride (CaCl2) as Catalyst for Asymmetric Organic Reactions
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Pybox–CaCl2 was found to be an efficient chiral catalyst for asymmetric 1,4-addition reactions of 1,3-dicarbonyl compounds with nitroalkenes, affording γ-nitro carbonyl compounds in high yields with high enantioselectivities. The reactions proceeded smoothly even in air, and were successfully applied to a continuous flow system.
KeywordsCalcium chloride Flow reaction C–C bond formation 1,4-Addition reaction Asymmetric catalysis
This work was partially supported by a Grant-in-Aid for Scientific Research from the Japan Society for the Promotion of Science (JSPS), and Japan Science and Technology Agency (JST).