Topics in Catalysis

, Volume 57, Issue 10–13, pp 935–939 | Cite as

Calcium Chloride (CaCl2) as Catalyst for Asymmetric Organic Reactions

  • Tetsu Tsubogo
  • Yasuhiro Yamashita
  • Shū Kobayashi
Original Paper

Abstract

Pybox–CaCl2 was found to be an efficient chiral catalyst for asymmetric 1,4-addition reactions of 1,3-dicarbonyl compounds with nitroalkenes, affording γ-nitro carbonyl compounds in high yields with high enantioselectivities. The reactions proceeded smoothly even in air, and were successfully applied to a continuous flow system.

Keywords

Calcium chloride Flow reaction C–C bond formation 1,4-Addition reaction Asymmetric catalysis 

Notes

Acknowledgments

This work was partially supported by a Grant-in-Aid for Scientific Research from the Japan Society for the Promotion of Science (JSPS), and Japan Science and Technology Agency (JST).

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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Tetsu Tsubogo
    • 1
  • Yasuhiro Yamashita
    • 1
  • Shū Kobayashi
    • 1
  1. 1.Department of Chemistry, School of ScienceThe University of TokyoBunkyo-kuJapan

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